One Health initiative to prevent resistance emergence

Azole-based antifungal drugs (fungicides) have contributed to reduced mortality rate for patients with serious fungal infections. Azole-based fungicides also have considerable economic value in the production and storage of agricultural products. This is important to ensure sufficient and safe food for a growing global population. Increasing azole resistance is therefore cause for concern. Our goal is to retain the azole class both for medical and agricultural use. Our goal with the network project AMRprevent was to use the thinking behind the preparation of the WHO's list of antibiotic-resistant "priority pathogens" and principles from antibacterial resistance management to reduce the development and spread of antifungal resistance. In short, we wanted to implement the Centers for Disease Control and Prevention's (CDC) One Health concept by bringing together researchers and stakeholders from different sectors and disciplines nationally and internationally to achieve greater awareness of the issue. The aim of the network project was to exchange experiences and knowledge and propose strategies for the management and prevention of antimicrobial resistance (AMR).

Vårt mål med nettverksprosjektet AMRprevent var å samle forskere og interessenter fra forskjellige sektorer og fagdisipliner nasjonalt og internasjonalt for å oppnå større bevissthet om antifungal resistens (AFR) og å utveksle erfaringer og kunnskap og foreslå strategier for forvaltning og forebygging av antimikrobiell resistens (AMR). Dette har vi gjort gjennom møter, foredrag og ulike typer formidling. Vi har utviklet og harmonisert metoder for soppdyrking, resistenstesting og dataanalyse for plantepatogene sopp og sopp som er patogene for mennesker og dyr. Dette gar generert kunnskap og erfaringer som vi vil ta med oss videre i forskning og formidling nasjonalt og internasjonalt.

AMRprevent is tailored to illuminate and collect knowledge about antimicrobial resistance (AMR) and identify knowledge gaps and research needs. The consortium is a based on an existing national, international and multidisciplinary collaboration joining renowned scientists from human and veterinary medicine, agriculture, mycologists, experts in fungal genetics and epidemiologists (Interdisciplinary think tank to minimize the emergence and spread of antifungal resistance – ResAzoleNet), but have been reinforced with bacteriologist with expertise on AMR. AMRprevent brings together research groups from different disciplines, sectors and institutions to illuminate the problem complexity and exchange knowledge and methods (WP1). The network will compile an assembly and comparison of existing knowledge on development of bacterial and fungal AMR in a One Health perspective (WP2), to propose new research projects (WP3). Routes of influence to relevant national and international authorities and stakeholders will be mapped, for distribution of the project results and recommendations of measures (WP4). Finally, an international workshop will be arranged to discuss and compare AMR, challenges and alternative measures across sectors and disciplines in a One Health perspective (WP1). In short, AMRprevent will implement Centers for disease Control and Prevention´s (CDC) concept of One Health by bringing together relevant partners, coordinate, collaborate and communicate in order to achieve the best health outcomes.