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BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Survival rates and long-term outcomes for patients with COVID-19 admitted to Norwegian ICUs

Alternative title: Nasjonal kartleggingsstudie av overlevelse og senplager etter intensivbehandling av COVID-19

Awarded: NOK 3.9 mill.

The study Survival rates and long-term outcomes for patients with COVID-19 admitted to Norwegian ICUS has two different aims. The first aim is to synthesis data from a National register (Norwegian Intensive care-and Pandemic register) on all COVID-19 patients in Norway admitted to an ICU. These results are of great public interest for many reasons. First of all, it will give us information on the severity of this novel virus, but also how the health care system has coped in treating the severe cases that was admitted to an ICU. The results will be compared to other patient populations admitted with acute respiratory failure, but most interestingly to survival rates from other countries. In addition, the data will give us a description on how the distribution of severe cases of COVID-19 have been within Norway (e.g., gender, age, risk factors, health regions etc.) The second aim of this study is to measure and describe health related challenges COVID-19 patients may experience during their first year from ICU admission. The health-related domains that will be investigated will capture both mental, physical and cognitive health. Knowledge from other patient population admitted to an ICU, indicates that these are the main domains that negatively affect the activity of daily living. Physical, mental and cognitive health challenges will be investigated for the Norwegian COVID-19 population, and will give important insight to the impact COVID-19 can have on survivors of severe cases, as well as the need for rehabilitation.

The study will be conducted as a collaborative study between Norwegian Intensive Care Register (NIR) and Oslo University Hospital. The study will explore and describe the Norwegian ICU-population with COVID-19. NIR is one of several national quality registries in the Norwegian health care system. Registration is mandatory for all ICU-admissions fulfilling specific criteria. This will increase the generalizability of the results. The data collected during the COVID-19 epidemic may also be compared to existing NIR data, particularly those obtained from previously registered influenza patients, to identify similarities and discrepancies in the management and outcomes in these groups of patients. Respiratory failure is the main cause of ICU-admission for COVID-19 patients. The present project will also collect follow-up data from the NIR registry for all survivors of COVID-19. The negative consequences of surviving an ICU stay has received increased attention in recent years, as decreased mortality rates have contributed to a high number of ICU survivors. It has been reported that survivors of ARF of any aetiology report substantial impairment in physical functioning and quality of life (QOL) up to 5 years after ICU discharge. The one-year follow-up study will include questionnaires that captures physical, psychological and mental health related challenges occurring after ICU treatment.

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BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering