A Novel Liquid Biopsy System

GreinDX is developing a novel liquid biopsy system that simultaneously assays multiple types of cancer biomarkers. The system aims to capture, identify, quantify, and analyse key tumor related biomarkers such as circulating tumor cells (CTCs), extracellular vesicles (exosomes), circulating tumor DNA (ctDNA) and circulating tumor proteins (ctPrt). The scarcity of these biomarkers and the heterogeneity of cancer require that the biomarkers are captured singularly and that they can be assayed individually. GreinDX aims to develop a novel liquid biopsy system that will accomplish this goal, and that holds promise to transform the current landscape of cancer diagnostics, cancer prognosis and personalized cancer therapy. This project will focus on development of the GreinDDisc which is the core component the system, and is designed to achieve high-yield simultaneous capture and rapid identification of CTCs, exosomes, ctDNA and ctPrt. Captured CTCs can be assayed and grown within the capturing GreinDDisc device. We combine advanced micro/nanotechnology, proprietary peptide aptamer technology and cell biology, and our new concept presents several cross disciplinary R&D challenges.

A liquid biopsy system that simultaneously assays multiple types of cancer biomarkers is an important goal within the oncology field. Such a system needs to recover, enrich, identify, and quantify key tumor related biomarkers such as circulating tumor cells (CTCs), extracellular vesicles (exosomes), circulating tumor DNA (ctDNA) and circulating tumor proteins (ctPrt). The scarcity of these biomarkers and the heterogeneity of cancer require that the biomarkers are captured singularly and that they can be assayed individually. GreinDX aims to develop a novel liquid biopsy system that will accomplish this goal, and that will transform the current landscape of cancer diagnostics, cancer prognosis and personalized cancer therapy. This project will focus on development of the GreinDDisc which is the core component the system, and is designed to achieve high-yield simultaneous capture and rapid identification of CTCs, exosomes, ctDNA and ctPrt. Captured CTCs can be assayed and grown within the capturing GreinDDisc device. We combine advanced micro/nanotechnology, proprietary peptide aptamer technology and cell biology, and our new concept presents several cross disciplinary R&D challenges.