Back to search

BIOTEK2021-Bioteknologi for verdiskaping

KSP-S: Bio-farming for bioactive compounds

Alternative title: Bioaktive komponenter fra Norske urter gir bedre fôr og pakketeknologi

Awarded: NOK 10.5 mill.

The objective of "Bio-farming for bioactive compounds" is to increase value in the Norwegian agricultural sector by producing bioactive compounds (phytogens) for addition to feed and packaging materials aimed to 1) increase shelf life of salmon feed 2) reduce winter ulcers in farmed fish 3) improve the health and intestinal flora in poultry, and 4) designing biodegradable and antimicrobial packaging materials. Effect of variety, cultivation system and climatic factors on concentration of bioactive compounds will be studied in nine herb species oregano, yarrow, peppermint, hops, roseroot, maral root, sweet wormwood, purslane, and rosemary. Bioactive compounds will be extracted and tested for antioxidant, antimicrobial and anti-inflammatory properties. The most potent extracts and active substances are selected based on unspecified (metabolomic) and targeted biochemical analyzes, laboratory tests and in experiments with salmon and chicken. Effects of additives in fish feed will be investigated in laboratory models, to determine the antimicrobial activity of herbal extracts and their fractions on the growth of pathogens for salmon. Effects will be measured on growth, health and immunity of salmon, and effects on specific tissues such as head, kidney, skin, intestines and blood. Effects from extracts added to feed for boilers will be investigated in laboratory studies and in a feeding experiment with broilers. The effects will be documented on performance, levels of intestinal pathogens, intestinal inflammation (necrotic enteritis lesions) and immune cells in peripheral blood and intestinal tissue. The third use of the extracts is to design new packaging materials for the food industry where antimicrobial herbal extracts are inserted into the packaging using technologies such as high-pressure treatment, ultrasound and electrospinning. The objective is for the antimicrobial properties to inhibit bacterial growth, increase shelf life and food safety in the product.

The objective for the “Bio-farming for bioactive compounds” projects is to document that it is possible to reduce fish diseases of farmed salmon, improve poultry health and gut microbiota and to design biodegradable packaging materials with antimicrobial properties using bioactive compounds from herbs. We have selected 9 Norwegian herbs expected to give high production of bioactive compounds. Growth conditions will be described related to climatic stress and upscaling of production for advanced closed green-house systems, open field, and growth tunnels. Bioactive compounds in herbs will then be extracted, fractionated, and isolated and screened for antioxidant, antimicrobial, anti-inflammatory characteristics. Analytical samples will be characterized by means of targeted and non-targeted metabolomics and in invitro testing. Effects of additives in fish feed will be examined in invitro test systems, determining antimicrobial activity of extracts, fractions, and isolates of herbs on the growth of Atlantic salmon pathogens. The benefits will be measured as impacts on growth, health, and immunity in fish, and physiological impacts on specific tissues (head kidney, skin, gut, blood). Benefitial effects from extracts as feed additives in poultry feed will be examined by in vitro and in vivo testing. The effects will be documented on anti-oxidant and anti-inflammatoric potential, performance, counts of intestinal pathogens, and microbiota profile. The third application is to design and optimize sustainable methods for incorporation of antimicrobial herb extract into food packaging materials, giving longer shelf life. Different cutting-edge technologies (High pressure processing, ultra-sound, and electrospinning) will be tested for an enhanced incorporation. The project is interdisciplinary, and collaboration and competence dissemination are important goals in the work.

Publications from Cristin

No publications found

No publications found

No publications found

No publications found

Activity:

BIOTEK2021-Bioteknologi for verdiskaping