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GLOBVAC-Global helse- og vaksin.forskn

SARS-CoV-2 infection in HIV-positive patients with or without antiretroviral therapy in sub-Saharan Africa

Alternative title: SARS-CoV-2-infeksjon hos HIV-positive pasienter med eller uten antiretroviral behandling i Afrika sør for Sahara

Awarded: NOK 0.50 mill.

Background: Sub-Saharan African populations are increasingly facing a double burden of disease involving the interaction between HIV-AIDS and non-communicable diseases. The risk of severe disease with Covid-19 infections increases with age, male sex, and with co-morbidities such as chronic lung disease, cardiovascular disease, and diabetes. With Covid-19 infections, the risks increases further in these patients. Currently, there are no data about SARS-CoV-2 infection in people living with HIV. Aims: 1) To assess the percentage of SARS-CoV-2 infection in people living with HIV admitted in outpatient clinics in South Africa and Nigeria; 2) To assess how many people living with HIV proceed to Covid-19 and to estimate severity of Covid-19; 3) To correlate severity of Covid-19 and mortality risk in people living with HIV with comorbidities; 4) To assess the association of antiretroviral therapy on severity of Covid-19 in people living with HIV; and 5) To assess the effects of Covid-19 on vascular function and coagulation during infection and recovery. Methods: Three groups of participants will be included: 1) people living with HIV without antiretroviral therapy but with SARS-CoV-2 infection; 2) people living with HIV with antiretroviral therapy and SARS-CoV-2 infection; 3) HIV-negative patients, sex- and age matched, infected with SARS-CoV-2. Norwegian involvement: A post-doc (part-time) located at Kristiania University College, will support the planning of the study WP2) and the data analysis. Prof. Knut Lundin, UIO, will lead the data analysis and interpretation (WP6) part of the project. Prof. Per Morten Fredriksen, Kristiania University College will lead the planning and execution phases of this project. The Norwegian team is specialized in public health assessment projects and data analysis. Impacts: This study provides an opportunity to study HIV-infected patients with or without antiretroviral terapi and HIV-negative controls co-infected with SARS-CoV-2. An article has been published that addresses the protocol and background for the study: Nandu Goswami, Per Morten Fredriksen, Knut Lundin, Chidozie Agu, Simiat Olanike Elias, Keo Shirley Motaung, Gerhard Cvirn, Harald Sourij, Evelyn Stelzl, Harald Kessler, Adam Salon , Bianca Brix, Benedicta Nkeh-Chungag. COVID-19 and its effects on Endothelium in HIV-Positive Patients in Sub-Saharan Africa: Cardiometabolic Risk, Thrombosis and Vascular Function (ENDOCOVID STUDY). BMC Infectious Diseases. (2021) 21: 719. https://doi.org/10.1186/s12879-021-06426-8. Data collection is proceeding as planned, with the limitations of the pandemic.

Background: Sub-Saharan African populations are increasingly facing a double burden of disease involving the interaction between HIV-AIDS and non-communicable diseases. The risk of severe disease with Covid-19 infections increases with age, male sex, and with co-morbidities such as chronic lung disease, cardiovascular disease, and diabetes. With Covid-19 infections, the risks increases further in these patients. Currently, there are no data about SARS-CoV-2 infection in people living with HIV. Aims: 1) To assess the percentage of SARS-CoV-2 infection in people living with HIV admitted in outpatient clinics in South Africa and Nigeria; 2) To assess how many people living with HIV proceed to Covid-19 and to estimate severity of Covid-19; 3) To correlate severity of Covid-19 and mortality risk in people living with HIV with comorbidities; 4) To assess the association of antiretroviral therapy on severity of Covid-19 in people living with HIV; and 5) To assess the effects of Covid-19 on vascular function and coagulation during infection and recovery. Methods: Three groups of participants will be included: 1) people living with HIV without antiretroviral therapy but with SARS-CoV-2 infection; 2) people living with HIV with antiretroviral therapy and SARS-CoV-2 infection; 3) HIV-negative patients, sex- and age matched, infected with SARS-CoV-2. Norwegian involvement: A post-doc (part-time) located at Kristiania University College, will support the planning of the study WP2) and the data analysis. Prof. Knut Lundin, UIO, will lead the data analysis and interpretation (WP6) part of the project. Prof. Fredriksen, Kristiania University College will lead the planning and execution phases of this project. The Norwegian team is specialized in public health assessment projects and data analysis. Impacts: This study provides an opportunity to study HIV-infected patients with or without antiretroviral terapi and HIV-negative controls co-infected with SARS-CoV-2.

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GLOBVAC-Global helse- og vaksin.forskn