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KVAL: Dental socket caps (SCaps) for alveolar bone regeneration.

Alternative title: Plugg til ekstraksjonsalveole (SCaps) for tilheling av kjevekam

Awarded: NOK 0.50 mill.

Project Number:


Project Period:

2021 - 2022

Funding received from:


Every day some people have their teeth extracted due to trauma or various diseases. Today, replacing missing or lost teeth by dental implants is considered routine treatment. However, regeneration of a bone socket after tooth extraction may require a long healing time. This might be accompanied by loss of bone volume of the alveolar rigde that is required to support dental implant placement. In such cases, bone grafts are needed to regenerate or rebuild these bone defects prior to dental implant placement. However, bone transplantation can be a challenging procedure considering the drawbacks of the bone grafts such as limited amount of bone tissue, donor site morbidity, infections, prolonged operation times and elevated costs. Therefore, the aim of this project is to produce synthetic caps (cover) named “SCap” with a novel design that could be used immediately after each tooth extraction to prevent or minimize loss of bone volume prior to implant placement. Our SCap is designed to fit into the socket after tooth extraction as well as covering bone defect during the healing period. The design of such complex structure is now possible using the 3D-printing technology. A substantial effort will be placed during the project period to evaluate the safety and efficacy of the developed SCap in a well-established preclinical models. We believe that the SCaps have the potential to enrich the preventive measures for bone loss after tooth extraction and reduce the cost of the dental implant treatment.

In order to apply dental implants to restore missing teeth, the alveolar bone ridge must be preserved or restored to the level resembling healthy bone. Currently a number of technologies are applied to provide guided bone regeneration directly after tooth extraction, however they are complicated in use as most of bone filler materials are in the form of granules or injectables requiring additional membranes and fixtures to keep the filler in place. In this project we propose a new method to prevent alveolar bone loss after tooth extraction. We propose a dental socket cap (SCap), a 3D-printed scaffolds acting as a dental socket plug, made of bioresorbable materials. Such structure could guide alveolar bone regeneration and prevent bone collapse. In addition, SCap design combines a bone support part with a functional membrane to aid in its own fixation. To verify the functionality of SCap, in this Qualification project we are going to test it in a dog extraction socket model. We believe that due to expanding dental market, this technology (3D-printed scaffolds) has a potential to be a commercial success and can compete with current marketed “conventional” solutions. The global dental membranes and bone graft substitutes market is expected to grow strongly in the future due to increasing geriatric population, new technologies and patient awareness for treatments, and it is estimated to reach US$ 1,628.90 Million by 2027.