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IS-AUR-Samarb.progr. Norge Frankrike

Peptoid nanotubes for cancer therapy

Awarded: NOK 80,000

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Project Period:

2022 - 2023


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Organic nanotubes are promising nanomaterials displaying many potential applications in nanotechnology, in particular nanomedicine. Nanomaterials with cylindrical or rod-like morphologies are of great advantage to get a longer circulation time in blood compared to spheres with similar chemistry and comparable size. In addition, rod-shaped nanomaterials can enhance tumor penetration compared to nanospheres. As a consequence, hollow cylindrical nanostructures generally exhibit a higher potential for drug delivery because of their high aspect ratio and versatile functionalities of inner, outer, and membrane walls. Organic nanotubes can be obtained by stacking of organic macrocycles (“disk-like”) via noncovalent interactions, such as p–p interactions and/or hydrogen bonding. In this proposal we plan to use peptoids (a biomimetic sequence defined polymer) for the construction of supramolecular nanotubes and the development of novel drug delivery systems. We will investigate the self-assembly properties of such materials and we will explore their ability to complex and deliver doxorubicin into cancer cells.

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IS-AUR-Samarb.progr. Norge Frankrike