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FORNY20-FORNY2020

KVAL: Novel treatment for dry mouth

Awarded: NOK 0.46 mill.

Project Manager:

Project Number:

332612

Project Period:

2021 - 2023

Funding received from:

Organisation:

Location:

Researchers at University of Oslo and Oslo University Hospital are developing a groundbreaking treatment for dry mouth, a condition affecting up to 30% of the adult population, particularly among the elderly and those on certain medications. Dry mouth can lead to difficulties with speech, swallowing, tooth decay, and oral infections, significantly impacting quality of life. Current dry mouth therapies require frequent application, have limited clinical effects, and only provide short-term relief. We aim to change this through our innovative approach. Our proposed solution involves the use of nano-formulated carbohydrate-coated liposomes. These are microscopic vesicles capable of adhering to the mucosal surfaces in the mouth, improving hydration over a longer duration, and reducing the frequency of treatment needed. The liposomes are coated with specific polysaccharides like alginate and chitosan, chosen for their strong muco-adhesive properties and high water sorption capacity. They slowly release hydration medium, keeping the mouth moist for extended periods. The project's next steps include optimizing the product, preparing for regulatory approval, and producing a clinical-grade batch for efficacy testing in patients. If successful, this treatment could revolutionize the management of dry mouth, enhancing the quality of life for millions of people worldwide while addressing a sizable and expanding market need.

The envisioned product would serve groups at risk for dry mouth encompass the elderly (particularly medicated ones), cancer patients undergoing radiation in the head and neck region, and individuals with autoimmune disorders like Sjögren’s syndrome. The product, a saliva substitute, can hydrate mucosal surfaces, with a spray format identified as the most efficient delivery method. It faces competition from a variety of brands in the market. The strategy revolves around tailoring the product based on patient feedback and targeting quality-conscious Western European consumers. Secrecy in product formulation is pivotal for its commercial success.The product aims to enhance oral health, especially for vulnerable groups, potentially reducing malnutrition and oral complications, benefiting society at large.

Funding scheme:

FORNY20-FORNY2020