High-throughput single sperm microfluidic filter

The quality of the sperm used for fertilization in human reproduction is crucial for a successful outcome, meaning a pregnancy that results in the birth of a healthy child. Today, sperm selection is primarily carried out using various outdated techniques that filter the good from the bad in bulk, while relying on harmful processes such as centrifugation and staining. These techniques - especially for IVF (in-vitro fertilization) and IUI (intrauterine insemination) - filter sperm in large quantities without accounting for individual analysis of the sperm cells. In this project, we introduce the device ActiveFilter, which can individually sort and filter sperm cells in quantities large enough for IVF and IUI. The invention uses modern algorithms and AI to analyse sperm in better details than today's solutions. The main goal of this project was to finalize the design, produce an MVP, and prepare the ActiveFilter for clinical testing. During the project period, we developed several prototypes to test and arrive at a design optimized for commercialization. We have identified, developed, and finalized the design necessary for an MVP - preparing AF for clinical testing and validation. The project is now better positioned for successfull commercialization.

Outcomes: The project has utilized both new and experienced participants, and has with no doubt improved their overall experience for ART and innovation. Additionally, it has introduced the innovation process from academia for the new participants. Impacts: Both technical and commercial risk are significantly reduced for the ActiveFilter unit thanks to prototype development and testing. We are now in dialog with end-users for further testing to prepare for eventual commercialization.