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Dato fra ny til gammel

KLINISK-Klinisk forskning

Genetic susceptibility and development of chronic sciatic pain - possible implications for future treatment

Previous findings suggest that development of chronic sciatic pain results from multiple functional changes in the peripheral and central nervous system. As described in this grant proposal, several recently described human genetic variants may affect suc h processes. Hence, individual genetic su...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Tumor Targeting Antibodies in Colorectal Cancer

Objective: The main purpose is to identify and characterize novel antibodies recognizing specific antigens on colorectal cancer cells. Interesting candidates will be thoroughly examined for their specificity and their ability to be used as diagnostic and/ or prognostic markers. Their potential as...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

KLINISK-Klinisk forskning

Stimulating self-management in patients with fibromyalgia syndrome through web-based situational feedback

Self-management of chronic pain is increasingly seen as an important tool in providing adequate care to patients with Fibromyalgia Syndrome (FMS) and other types of Chronic Non-malignant Pain. Enhancing the patient's self-management of his condition is th ought to be effective in reducing pain an...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Medication assisted rehabilitation and crime; how do MMT affect crime rates and patterns?

It is still not known fully to which extent MMT offers crime reduction as a mean of harm reduction for heroin addicts in Norway. New knowledge of crime reduction patterns based on cross-registry studies and in-dept studies on crime patterns will give impo rtant new knowledge for program planners ...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

KLINISK-Klinisk forskning

Does fusion lead to increased adjacent level disc degeneration in patients with chronic low back pain. An international collaborate project.

There is controversy as to whether fusion of one or more motion segments of the spine results in accelerated degeneration of the adjacent segment over time. Some argue that adjacent segment is exposed to increased mechanical stress, which accelerates disc degeneration, whilst others maintain tha...

Tildelt: kr 3,9 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FOLKEHELSE-Folkehelse

Energy Balance and Breast Cancer Aspects. A randomised clinical trial with physical activity interventio

Breast cancer requires intense and prolonged treatments often associated with significant side effects, also influencing their levels of physical activity after diagnosis. New evidence from large cohort studies supports a role of physical activity in redu cing recurrence and improving survival. A...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Effects of Pregnancy, Lactation and Menopause on Bone Health

Fragility fractures are a common public health problem particularly in Scandinavia. The pathogenesis of bone fragility is multi-factorial. Two factors will be studied ? the effect of pregnancy and menopause. Whether pregnancy and lactation result in bo ne loss is not clear, and if so, whether ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2010

Sted: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Multi-modal imaging: The importance of fiber connections for cognitive function, brain activity and brain structure in research and clinic

The main objectives of this project are 1) integration of informations from different neuroimaging methods (diffusion tensor imaging [DTI], structural MRI, functional MRI [fMRI], event-related potentials [ERP]) and refined cognitive measures, 2) use these methods to understand the biological fou...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Immunopathogenic mechanisms in coronary artery disease

Despite state of the art cardiovascular treatment, coronary artery disease (CAD) with development of acute coronary syndromes are still common manifestations of atherosclerosis, suggesting that important pathogenic mechanisms remain active and unmodified by the present treatment modalities. Based...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

S-AFRIKA-Program for forskningsamarbeid med Sør- Afrika

A Translational Effort to Develop Novel Magnetic Resonance Imaging Protocols and Sequences for Studying Myocardial Lethal Reperfusion Injury

Cardiovascular disease remains a leading cause of death worldwide. Impaired coronary circulation in the heart following a myocardial ischemic episode will lead to compromised hemodynamic function and ultimately cell death. Coronary reperfusion is the only means of limiting infarct size, provided...

Tildelt: kr 0,79 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Functional genomics and diabetes in Norway - Clinical, molecular, cellular and epidemiological analysis of monogenic diabetes

Diabetes is a common and severe disease. Maturity-onset diabetes of the young (MODY) is an inherited type of diabetes with decreased insulin secretion. Based on our national MODY Registry, we have recently identified a novel syndrome of exocrine and endoc rine pancreatic dysfunction caused by mut...

Tildelt: kr 8,5 mill.

Prosjektperiode: 2007-2012

Sted: Ukjent Fylke

S-AFRIKA-Program for forskningsamarbeid med Sør- Afrika

Nutritional intervention and novel diagnostics to improve community-based control of tuberculosis

Tuberculosis (TB) is a major public health problem in developing countries as well as in the Republic of South Africa (RSA). Despite significant strides in case detection and treatment, the prevalence of TB continues to rise at an alarming, also in the RS A. More effective diagnostic methods are ...

Tildelt: kr 0,29 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

S-AFRIKA-Program for forskningsamarbeid med Sør- Afrika

Characterization of the Mycobacterium tuberculosis phosphorylome and its role in pathogenesis

Tuberculosis (TB) remains a major global public health concern. Approximately 2 million people die per year from TB, with South East Asia, Sub-Saharan Africa and Eastern Europe showing the highest levels of new cases and deaths. South Africa is one of the countries with the highest number of TB ...

Tildelt: kr 0,80 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

FORNY-3-Kommersialisering av FoUresultater

Kommersialiseringsstipend: Utvikling av teknologi for spesifikk anriking, deteksjon og kvantitering av citrullinerte peptider og proteiner.

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Tildelt: kr 0,57 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

SFI-Sentre for forskningsdrevet innovasjon

Medical Imaging Laboratory

Sentre for forskningsdrevet innovasjon (SFI) er en nyskapning der flere industripartnere, universitet og sykehus arbeider sammen i et åpent forskningsmiljø. MI Lab var i stand til å skape et tverrfaglig miljø for åpen innovasjon og langsiktig industriell forskning med høy vitenskapelig kvalitet o...

Tildelt: kr 80,0 mill.

Prosjektperiode: 2007-2015

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Targeting occult tumor cell dissemination in localised breast cancer

For the future, a better treatment of patients with breast cancer is dependent upon a better assessment of the individual risk of harbouring minimal residual disease after the completion of the surgical treatment. The aim is to separate very low risk pati ents from high risk patients for future m...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

SFI-Sentre for forskningsdrevet innovasjon

Tromsø Telemedicine Laboratory: Research-Based Innovation in Telemedicine and eHealth Systems for Chronic, Age, & Lifestyle related Diseases

TTL har i 2013 hatt rekordhøy vitenskapelig produksjon med 8 avlagte doktorgrader og et jevnt høyt antall vitenskapelige publikasjoner (36), proceedings (28) og bokkapitler (4). I tillegg er det 12 som skriver doktorgrad per i dag og som er i oppløpet . 2014 er det ventet et like høyt antall av...

Tildelt: kr 80,0 mill.

Prosjektperiode: 2007-2015

Sted: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Molecular and clinical aspects of cancer

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Tildelt: kr 1,5 mill.

Prosjektperiode: 2007-2009

Sted: Troms - Romsa - Tromssa

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Non-invasive in vivo imaging of neural stem cells

Stem cell biology is one of the most closely followed developments in biomedicine today, since stem cells may provide the foundation for rational regenerative therapeutics with far-reaching implications in the health sector. The use of stem cells to gener ate new nerve cells has received particul...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The Norwegian Multiple Sclerosis Registry and Biobank

Multiple sclerosis (MS) is an immune-mediated, inflammatory disease of the central nervous system (CNS) in genetically susceptible individuals. It is a disabling disease of young adults, with no curable treatment available. There is growing knowledge of s everal aspects of the disease, but the et...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

BIA-Brukerstyrt innovasjonsarena

DualPET-MR

The main objective for this project is to develop dual-modality PET-MR for molecular biology and medicine which will allow for the combined and simultaneous use of positron emission tomography (PET) and magnetic resonance (MR). In such a combined machine the PET provides information from molecula...

Tildelt: kr 5,1 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Gene-environment interaction analyses and oral clefts in Norway

Norway has several large epidemiological studies with genetic bio-banks that may be used in etiologic research. Examples are the CONOR-cohort and the MoBa-cohort of children with mothers and fathers. Optimal analysis of such studies requires integration o f both genetic and environmental effects....

Tildelt: kr 2,8 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FRIMED-Klinisk medisin og folkehelse

Combined structural, microvascular and functional mapping of brain tumors for improved diagnosis and treatment planning

During recent years, the department of radiology at Rikshospitalet-Radiumhospitalet (RR) Medical Center has had a strong focus on functional MRI (Magnetic Resonance Imaging) research; including perfusion/ diffusion MRI and spectroscopy, with the aim of br inging novel MR techniques into early cli...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

High-resolution fMRI of the function of hippocampal subfields during encoding and retrieval of episodic memory in humans.

Research during past 50 years has firmly established the hippocampus as an essential structure for episodic and semantic memory. However, we know little about the function of the diverse hippocampal networks and subfields in memory formation. New evidence from our group at The Centre for the Bio...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

FRIMED-Klinisk medisin og folkehelse

L-Ornithine and phenylacetate: A novel and effective therapy for hepatic encephalopathy

Background: The major therapeutic target for the treatment of hepatic encephalopathy is ammonia. Our extensive investigations in animal models and also in humans with cirrhosis support the view that the major organ removing ammonia in patients with cirrho sis is the muscle, converting ammonia to ...

Tildelt: kr 1,3 mill.

Prosjektperiode: 2007-2009

Sted: Troms - Romsa - Tromssa

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Development and clinical testing of juice rich in phytochemicals and antioxidants

We will develop juice rich in natural antioxidants and phytochemicals and test bioactivity in clinical trials. Specifically, together with TINE R&D we aim at develop two juices based on grapes, pomegranates and/or blueberries. By screening potential ingre dients available on the marked we will op...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

GLOBHELS-Global helse

New rotavirus vaccines: targeting childhood morbidity and mortality in low- and middle-income countries in Central Asia

The current project is aimed at reducing morbidity and mortality caused by rotavirus (RV) disease among young children in low- and middle-income countries in Central Asia. RV is the most common cause of severe acute gastroenteritis in young children and a major cause of childhood death in develo...

Tildelt: kr 8,8 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

GLOBHELS-Global helse

Further Developments of New Immunogenic Peptide-based HIV Vaccines Targeting Dendritic Cells

Therapeutic HIV vaccines targeting dendritic cells have so far shown more promising results than preventive HIV vaccines and may become an alternative even for prophylaxis. This Proposal describes plans for basic clinical studies on further characterizati on and developments of new immunization s...

Tildelt: kr 7,4 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

THE HORDALAND WOMEN'S COHORT STUDY. A planned 15-year (1997-2012) follow up incidence study of urinary incontinence, and associated factors

Urinary incontinence (UI) is a common condition with a prevalence of about 25% of adult women, that affects the physical, psychosocial, and economic well-being. Longitudinal studies of incidence, remission and natural history are scarce. The Hordaland wo men's cohort study is an ongoing 15-year ...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FRIMED-Klinisk medisin og folkehelse

Exposure expression profiles in a prospective cancer study - The Norwegian Women and Cancer postgenome cohort

From 1991 women in Norway has been recruited to participate in NOWAC by postal questionnaires. They are drawn at random from the population through the central person register. Follow-up on cancer and death is based on linkage to national registers. Altog ether 150 000 women aged 30-70 years at r...

Tildelt: kr 1,6 mill.

Prosjektperiode: 2007-2010

Sted: Troms - Romsa - Tromssa

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