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BEDREHELSE-Bedre helse og livskvalitet

Fungal particles in indoor air: occurrence and toxic properties of viable and non-viable spores, hyphae and fragments

PhD1 Frigjøring av sporer og fragmenter fra 2 og 8 uker gamle soppkulturer av Aspergillus fumigatus (AF), Aspergillus versicolor (AV) og Penicillium chrysogenum (PC) ble studert med to generatorer, tre medier og to lufthastigheter. Det frigjøres sub-? fragmenter fra soppkulturene i tillegg til s...

Tildelt: kr 7,6 mill.

Prosjektperiode: 2010-2019

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Internal exposure to bisphenol A and phthalates - Sources, pathways and relationship to effects

Phthalates and bisphenol A are commercially important classes of industrial chemicals used in a wide variety of consumer products. Many of these compounds have been identified as endocrine disruptors causing functional and structural impairment of reprodu ction and development. Furthermore, epide...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Air pollution, birth outcomes and early respiratory health - taking gene environmental interactions into account

Selv om sammenhengen mellom utendørs luftforurensning og diverse helsetilstander har vært studert i mange undersøkelser, er det fortsatt usikkerhet om mange forhold. Dette gjelder ikke minst om luftforurensing under svangerskapet kan ha betydning for mor og barns helse. I denne undersøkelsen vil...

Tildelt: kr 3,6 mill.

Prosjektperiode: 2010-2016

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Neurodevelopmental toxicity caused by environmental exposure to phthalates and Bisphenol A

I de siste tiårene har det kommet stadig nye beviser for at miljøkjemikalier som ftalater og bisfenol A (BPA) kan føre til nevronal utviklingsskade. Man er derfor bekymret for effektene disse stoffene kan ha på nervesystemet hos fostre, spedbarn og barn. I tråd med dette har EU-kommisjonen og der...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2010-2015

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Researcher project: Interplay between environmental contaminants, genes and diet in obesity and intestinal cancer

En parallell økning i overvekt/fedme og ulike krefttyper er sett de siste tre tiår. Fedme antas å øke risikoen for kreft, inkludert tarmkreft, men mekanismene er uklare. Samtidig har vi blitt utsatt for mer forurensende stoffer i miljøet (miljøkontaminanter). Vi har studert sammenhengen mellom fe...

Tildelt: kr 4,8 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Nutrients, genes and epigenetic modification of DNA in relation to asthma and atopy.

This project is based on the Norwegian Mother and Child Cohort Study (MoBa). While limited human evidence is available on the association of childhood atopic diseases with maternal diet during pregnancy and gene methylation in the offspring, new murine st udies from our collaborators at the Natio...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2008-2014

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Importance of components and sources in particle-induced lung inflammation: Role of PAHs and metals

Ambient particulate matter (PM) contribute to the development of adverse health effects in the lung and cardiovascular systems. PM has a complex composition and may contain a variety of different organic compounds and metals. We will investigate the possi ble role of PAHs and metals in PM-induced...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Environmental mercury and human health in Arctic Norway

Persistent pollutants in Arctic areas have received much attention. It is well known that these contaminants accumulate in food webs and potentially cause severe physiological damages to top level predators including humans. People in Arctic regions tend to be more exposed to these pollutants due...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Environmental exposure to phthalates and Bisphenol A and the development of diabetes and asthma - an in vivo and in vitro study

Asthma, allergy and diabetes increased during the last decades. These diseases are caused by dysfunction of the immune system. Diabetes and allergic diseases could share common underlying immunological mechanisms and environmental causes. Our hypothesis i s that the two groups of chemicals, phtha...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Salmon and contaminants: impacts on insulin sensitivity and metabolic diseases

Although marine food has long been known to have health properties, its roles and impacts on insulin sensitivity and metabolic diseases (e.g. type 2 diabetes, obesity, hypertension, coronary heart diseases etc.) remain still unclear and worldwide debated. Beside its potential health effects, rec...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2011

Sted: Vestland

MILPAAHEL-Miljøpåvirkning og helse

Oil induced autoimmune disease

We here present evidence that environmental exposure to immunoadjuvants in particular mineral oils, may precipitate autoimmune diseases in susceptible individuals, and that a novel class of genes encoding leukocyte regulatory receptors contribute to this susceptibility. The evidence is based on t...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Type 1 Diabetes and the Hygiene Hypothesis (helminths and parasites, and symptomatic virus infections)

Type 1 Diabetes (T1D) is one of the most prevalent chronic diseases with childhood onset. The incidence of T1D has increased with 25% during the last three years, and threefold during the last generation. The disease has a multifactorial aetiology and app ears after a long period where the immune...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Toxicological characterization of selected secondary fungal metabolites in Norwegian grain

Grains are commonly infected with toxigenic fungi, particularly with species of the Fusarium and Alternaria genera. Fusarium fungi are producers of a range of well known mycotoxins as well as less known bioactive metabolites for which little toxicological information exists. Food and feed contai...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2008-2012

Sted: Akershus

MILGENHEL-Miljø, gener og helse

Forskningskoordinator på Program for Miljø, gener og helse

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Tildelt: kr 0,62 mill.

Prosjektperiode: 2008-2010

Sted: Ukjent Fylke

MILPAAHEL-Miljøpåvirkning og helse

Hearing loss and tinnitus: genetic and environmental effects

Depending on the criteria used 1/3 - 1/6 of the population experience hearing impairment. Tinnitus is defined as the sensation of sound without any outer sound stimulus present. Environmental risk factors such as noise exposure are frequently described fo r both the diseases. A genetic component ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2008-2015

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Health effects related to environmental exposure in an industrial community

Environmental monitoring has shown relatively high levels of heavy metals like cadmium, mercury and lead in residential areas in the industrial town of Odda. The main objective of this project is to provide new knowledge about the association between envi ronmental exposure to chemical factors an...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2013

Sted: Vestland

MILPAAHEL-Miljøpåvirkning og helse

Population exposure and health impact associated with indoor air pollution from household solid fuel burning in developing countries

Almost 3 billion people worldwide use traditional fuels for home cooking and heating. It is well documented that high levels of air pollution from solid fuel burning contribute to enhanced rates of acute and chronic respiratory diseases. According to the World Health Organization, smoke from soli...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Preventive vaccination against allergy: the effect in offspring of maternal allergen exposure and immune response

Allergy-related diseases affect in the order of 30% of the population, and represent one of the most common health problems caused by environmental factors in interplay with genetically and epigenetically determined susceptibility of the individual. The causes for allergy are largely unknown, a...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Dioxin-like Organohalogen Carcinogenesis

Dioxin-like organohalogens include polychlorinated dibenzodioxins, dibenzofurans and 11 planar bifenyls (PCB). In addition, brominated flame retardants (PCDE) may share many of their characteristics. They are persistent environmental pollutants which acc umulate in food chains. Human exposure oc...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Germ cell DNA damage and its impact on early embryo development

An apparent decline in semen quality has occurred during the past half century which is most likely related to environmental exposure; however, the agent(s) responsible have not been identified. Endocrine disruptors acting prenatally may be responsible bu t have yet to be shown as relevant for hu...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

MILGENHEL-Miljø, gener og helse

Cardiovascular morbidity and mortality: Effects of noise or air pollution or both?

Since road traffic is a source of both air pollutants and noise, it is very important to disentangle the health effects of the two very different types of environmental exposures related to road traffic. There are indications that both noise and air pollu tion are associated with increased risk o...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Health Effects of Dietary DNA from Novel foods

The major fraction of DNA present in the food (dietary DNA) is degraded in the gastrointestinal tract. However, it is a recent and novel finding that a substantial fraction of intact dietary DNA, several hundred base pairs long, is taken up from the gastr ointestinal tract and distributed to bloo...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Akershus

MILGENHEL-Miljø, gener og helse

Persistent toxic substances (PTS), reproductive health and pregnancy outcome in Northern Norway

A number of persistent toxic substances (PTS) are recognised as being responsible for adverse development and health effect in children. The growing foetus and new born child are especially sensitive to the toxic effects of many persistent heavy metals an d organic pollutants found in the environ...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2009

Sted: Troms - Romsa - Tromssa

MILGENHEL-Miljø, gener og helse

The mechanisms behind toxic effects of POPs

Environmental exposure to persistent organic pollutants (POPs) such as dioxins, polychlorinated biphenyls (PCBs), organochlorine pesticides (OP) and brominated flame retardants (BFRs) is an emotive and sensitive subject. Questions have been raised among t he scientific community, policy makers an...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

MILPAAHEL-Miljøpåvirkning og helse

Thermolysis of carbohydrates and intestinal cancer risk.

Increased colorectal cancer risk is associated with a Western style diet and several carcinogenic and hazardous compounds are formed during heat processing. Acrylamide is formed in µg/amounts during heating of sugar-rich foods, but 5-hydroxymethylfurfural (HMF) is produced in much larger quantit...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

MILGENHEL-Miljø, gener og helse

Food from the sea - health effects of organic pollutants and essential nutrients from marine food. The Norwegian Women and Cancer Study.

In the Norwegian Women and Cancer study (NOWAC), detailed dietary information is available in addition to a large biobank. Altogether 68 000 women aged 41-70 years at recruitment have been followed up for cancer incidence and mortality through linkages to national registers based on the unique n...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2006-2009

Sted: Troms - Romsa - Tromssa

MILPAAHEL-Miljøpåvirkning og helse

The effect of polychlorinated biphenyls and brominated flame retardants on dopaminergic systems. A possible explanation for toxic effects.

The proposed project is to study in what way both molecular mechanisms and electrophysiological responses induced by treatment with PCB and BFR will affect the phosphorylation pattern of glutamate receptors in defined brain regions in controls and mice wi th deletion of the DARPP-32 gene.

Tildelt: kr 2,1 mill.

Prosjektperiode: 2006-2014

Sted: Oslo

MILGENHEL-Miljø, gener og helse

Nano-sized versus larger particles: Does extremely small size introduce unique mechanisms for particle-induced toxicity?

Nanoparticles (NP) have been suggested to be important factors in inducing lung and heart disease of particulate air pollution (PM), and are also increasingly used in industry and medicine. Thus, there is an increasing concern for both public and occupati onal exposure. Generally, inflammation is...

Tildelt: kr 2,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

MILGENHEL-Miljø, gener og helse

Human exposure pathways of polyfluorinated compounds and brominated flame retardants used in consumer products as inputs to risk assessment

Recently, concerns have risen about the increasing occurrence of polyfluorinated alkyl compounds (PFCs) and brominated flame retardants (BFRs) in the environment, compounds that are widely used in consumer products. The exposure of humans to PFCs and BFRs and the potential associated health risk...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

MILGENHEL-Miljø, gener og helse

Aryl hydrocarbon receptor mediated responses to environmental toxicants

A group of environmental pollutants, which may pose a potential health risk to humans, is the polycyclic aromatic hydrocarbons (PAHs). PAHs are found in urban air and occupational environments, and a very large part of the population is exposed to these c ompounds. An important source of PAH expo...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

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