204 antall prosjekter

Dato fra ny til gammel

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Genome-wide chromatin regulatory signatures in an ultra-compact chordate genome

Kromatin inneholder genetisk informasjon som kan leses og brukes til å styre en rekke forskjellige funksjoner i celler og organismer. Histon H3 variantene spiller en nøkkelrolle i kromatin. Disse proteinene dikterer hvordan kromatinet settes sammen. og deres post-transkripsjonelle modifiseringer ...

Tildelt: kr 4,1 mill.

Prosjektperiode: 2011-2017

Sted: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Regulation of chromatin remodeling and gene activity by A-kinase anchoring proteins

The nuclear matrix is essential for controlling gene expression in eukaryotic nuclei by organizing chromatin and orchestrating nuclear processes such as replication and transcription. AKAP95 is the major PKA and PP1-binding A-kinase anchoring protein (AKA P) of the nucleus; yet its function in in...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2011-2014

Sted: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Neil3, a novel function for self-renewal and proliferation of neural progenitor cells

The major cell types comprising the mammalian central nervous system arise from neural stem cells (NSC) and progenitor cells (NPC), including neurons, astrocytes and oligodendrocytes. In this proposal we aim to characterize a novel gene function, Neil3, r equired for neural stem/progenitor cell m...

Tildelt: kr 3,8 mill.

Prosjektperiode: 2011-2015

Sted: Oslo - Oslove

FORINFRA-Nasjonal sats.på forskningsinfrastrukt.

A national infrastructure for biobanks and biobank related activity in Norway

There has been an accelerating interest by researchers world wide in gaining access to Norwegian biobanks with their comprehensive samples and data collections. In parallel, Norwegian researchers have gained increased competence and impact in this field, acknowledging the necessity to collabora...

Tildelt: kr 79,6 mill.

Prosjektperiode: 2011-2017

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The complement system and the CD14/TLR4/MD2 complex as targets for therapy in sepsis.

Prosjektet tar sikte på å utvikle et nytt terapeutisk regime ved tilstander hvor det medfødte immunapparatet er over-aktivert og gir opphav til alvorlig sykdom, slik man ser det ved sepsis (blodforgiftning). Vi har i tidligere studier vist at hemming av to viktige grener av immunapparatet, komple...

Tildelt: kr 8,1 mill.

Prosjektperiode: 2011-2017

Sted: Oslo - Oslove

IS-AUR-Samarb.progr. mellom Norge og Frankrike

Inhibiting protein-membrane interactions: towards new therapeutic strategies

The goal of the present proposal is to find compounds able to hinder the binding of Proteinase 3 to the neutrophil plasma membrane in vitro. Proteinase 3 is a neutrophil enzyme, present at the surface of the neutrophil plasma membrane and which has been i dentified as a drug target for a number o...

Tildelt: kr 28 700

Prosjektperiode: 2011-2013

Sted: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Localisation, regulation and functional significance of the SMC-loading complex during eukaryotic cell division.

The strucural maintenance of chromosome (SMC)-complexes organise and stabilise higher order chromosomal conformations during normal cell division, e.g. condensation of chromosomes cell division or generation of inactive chromatin, cohesion of newly replic ated sister chromatids and stabilisation ...

Tildelt: kr 1,5 mill.

Prosjektperiode: 2011-2015

Sted: Ukjent Fylke

NAERINGSPH-Nærings-phd

Økt kompetanse om autoimmune sykdommer hos hund ved studier av forekomst, etiologi og behandling av viktige autoimmune sykdommer hos hund

Kloløsning er en sykdom der hundene mister klørne sine på noen måneder. Sykdommen er smertefull og nedsetter disse hundenes livskvalitet i den akutte fasen. Kloløsning er beskrevet på mange forskjellige raser, men ikke på gordon eller engelsk settere. Før ste studiet i denne doktorgraden har derf...

Tildelt: kr 1,9 mill.

Prosjektperiode: 2011-2015

Sted: Østfold

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Therapeutic Strategies to Interfere with Inhibition of Anti-tumor Immune Activity Mediated by Regulatory T cells

Prosjektet undersøker en type hvite blodlegemer (regulatoriske T celler) som hemmer andre T celler i immunforsvaret og justerer immunresponser. Disse regulatoriske cellene er normalt viktige for å forhindre autoimmunitet og reumatiske sykdommer. Hvis de derimot virker for sterkt kan det bidra ...

Tildelt: kr 7,8 mill.

Prosjektperiode: 2011-2015

Sted: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Defining the role of Axl in normal and malignant mammary stem cells

Metastasis accounts for >90% of cancer-related mortality. Malignant cells carry oncogenic mutations that engender uncontrolled growth and epigenetic activation of stem cell features, chemotherapeutic resistance, immune modulation and metastasis. Tumor cel l epithelial-to-mesenchymal transition (E...

Tildelt: kr 4,8 mill.

Prosjektperiode: 2011-2015

Sted: Vestland

IS-DAAD-Forskerutveksling Norge-Tyskland

Dissecting the developing vestibulo-ocular reflex circuit: Pharmacogenetic and optogenetic manipulation

A fundamental question in neuroscience is how neuronal circuits are assembled during embryonic and fetal development. Critical features include the establishment of functionally appropriate patterns of synaptic connections and a proper balance between exc itatory and inhibitory connections. Senso...

Tildelt: kr 34 661

Prosjektperiode: 2011-2013

Sted: Oslo - Oslove

FRIBIO-Biologi og biomedisin

Parasites and infectious diseases in a changing world - 4th Scandinavian-Baltic Congress for Parasitology

The biennial research conference of the Scandinavian-Baltic Society for Parasitology (SBSP) is to be held at the University of Oslo, Blindern campus, and Natural History Museum, Tøyen, between the 19th and 22nd June 2011, with Professor T.A. Bakke (Natura l History Museum, University of Oslo) as ...

Tildelt: kr 44 831

Prosjektperiode: 2011-2011

Sted: Oslo - Oslove

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Small RNAs and DNA repair in Mycobacterium tuberculosis adaptive responses

Tuberkulose (TB) er en av verdens mest utbredte infeksjoner, som tar nesten 1.3 millioner liv og forårsaker 8.7 millioner infeksjonstilfeller årlig. Årsaken er Mycobacterium tuberculosis (Mtb), som infiserer 1/3 av verdens befolkning og har forårsaket flere dødsfall enn noen annen mikrobe. Behand...

Tildelt: kr 3,8 mill.

Prosjektperiode: 2011-2014

Sted: Oslo - Oslove

IS-AUR-Samarb.progr. mellom Norge og Frankrike

Functional mapping of brainstem-spinal motor circuits

Understanding how specific groups of neurons contribute to behaviour is a formidable challenge which in mammals requires studying extensive networks. Many motor networks encompass large areas of the central nervous system, mostly due to the presence of lo ng axonal connections such as those conne...

Tildelt: kr 60 943

Prosjektperiode: 2011-2013

Sted: Oslo - Oslove

IS-AUR-Samarb.progr. mellom Norge og Frankrike

MODULATING AQUAPORIN FUNCTION WITH PEPTIDE APTAMERS

The objective of this proposal is to facilitate the exchange between the CNRS/ENS Lyon Team and the University of Oslo Team to investigate the effect of specific peptide aptamers on aquaporin (AQP) function while investigating the expression and fate of A QP-interacting proteins. A fortuitous obs...

Tildelt: kr 80 000

Prosjektperiode: 2011-2013

Sted: Oslo - Oslove

IS-BILAT-Mobilitet Norge-USA /Canada

Molecular heterogeneity of breast carcinomas; clinical implication of tumor subclones.

Breast carcinomas are considered a heterogeneous tumor type both at the clinical, pathological and molecular level, and individual tumors can display a wide range of molecular variation. Recent work separating tumor cells into subfractions based on differ entially expressed cell surface markers h...

Tildelt: kr 0,21 mill.

Prosjektperiode: 2010-2011

Sted: Oslo - Oslove

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Mechanisms of memory retrieval in the hippocampus

The discovery that hippocampal cells have location-specific activation (place cells), which is extremely reliable and observable during almost any behaviour in a moving rat made the possibility to study neuronal processes and behaviour together. Recent ad vances suggest that place is represented ...

Tildelt: kr 93 999

Prosjektperiode: 2010-2011

Sted: Ukjent Fylke

FORNY20-FORNY2020

Oxycare - Treatment for Bacteria Infected Wounds

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Tildelt: kr 2,8 mill.

Prosjektperiode: 2010-2013

Sted: Oslo - Oslove

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Medical Image Registration of 3D Datasets

This Yggdrasil proposal represents a truly multidisciplinary project consisting of two organ-specific applications - multimodal MR imaging and image registration in the study of brain-behavior relationships in cognitive aging, and motion correction of dyn amic contrast enhanced MRI for the quanti...

Tildelt: kr 0,13 mill.

Prosjektperiode: 2010-2011

Sted: Ukjent Fylke

FORNY20-FORNY2020

New lead compound for tuberculosis treatment

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Tildelt: kr 2,1 mill.

Prosjektperiode: 2010-2013

Sted: Troms - Romsa - Tromssa

FORNY20-FORNY2020

En ny telomerase kreftvaksine

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Tildelt: kr 2,8 mill.

Prosjektperiode: 2010-2012

Sted: Oslo - Oslove

FORNY20-FORNY2020

Small toxic membrane peptides to treat bacterial infections

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Tildelt: kr 2,0 mill.

Prosjektperiode: 2010-2012

Sted: Oslo - Oslove

FORNY20-FORNY2020

New Drugs for Treatment of Cerebral Edema 2

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Tildelt: kr 0,93 mill.

Prosjektperiode: 2010-2011

Sted: Oslo - Oslove

IS-TOPP-Toppfinans. av M.Curie-stipend

Prostate research organizations-network of early stage training (PRO-NEST) - Harri Itkonen

New and recent developments have revolutionized the prostate cancer research and clinical arenas, requiring the next generation scientists to have comprehensive knowledge and expertise in basic, clinical and applied research. PRO-NEST offers young researc hers a European integrated, multi-discipl...

Tildelt: kr 0,59 mill.

Prosjektperiode: 2010-2013

Sted: Oslo - Oslove

BIONÆR-Bionæringsprogram

Mapping and identification of the mutation causing Progressive Retinal Atrophy (PRA) in Shetland sheepdog

Prosjektet har hatt en god framdrift. Etter at vi tidligere i prosjektet identifiserte en genomisk region der det finnes risikogener for sykdommen har vi i 2014 og 2015 fortsatt arbeidet med å beskrive den genomiske regionen. Totalt har det vært samlet inn blodprøver fra ca 220 hunder, 31 hunder ...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2010-2016

Sted: Akershus

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

A whole-genome approach to monogenic and type 1 diabetes: Copy-number variation and exome screening

Diabetes is an epidemically increasing, common disease with high morbidity. Recently, there has been a break-through in the identification of diabetes risk genes. Although the genome-wide association studies in type 2 diabetes have been successful in iden tifying common gene variants associated w...

Tildelt: kr 9,7 mill.

Prosjektperiode: 2010-2014

Sted: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The AlkB family of hydroxylases; unique roles in DNA, RNA and histone hydroxylation/demethylation.

This project is partly based upon the intriguing phenotype and breeding pattern of Alkbh1, Alkbh4 and Alkbh7 (AlkB homolog 1, 4 and 7) targeted mice. Alkbh1 targeting in mice cause sex-ratio distortion and asymmetric left-right eye development. Alkbh1 is highly expressed in embryonic stem (ES) c...

Tildelt: kr 6,8 mill.

Prosjektperiode: 2010-2015

Sted: Oslo - Oslove

BIONÆR-Bionæringsprogram

HESTEFORSK Immune reactivity in the intestinal mucosa of healthy horses and of horses with chronic inflammatory bowel disease (H0947249)

In the horse, the immune system of the intestine is only little explored and the knowledge of the immunopthogenesis of intestinal inflammation is poor, which is an obstacle to effective therapies. This project aims at new knowledge of (1) the normal immun ology of the intestinal lymhoid tissue an...

Tildelt: kr 0,53 mill.

Prosjektperiode: 2010-2015

Sted: Oslo - Oslove

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Hormone-dependent cancers in the female: Comparative genomics approaches in breast, ovarian, cervix and endometrial cancers

Cancer is said to be a genetic disease based on the large number of genome variations present in cancer cells. Cancers specific for women - breast, ovarian, cervical and endometrial - represent a major health problem due to their high incidence and mortal ity rates. DNA copy number alterations ...

Tildelt: kr 34 000

Prosjektperiode: 2009-2009

Sted: Ukjent Fylke

IS-BILAT-Mobilitet Norge-USA /Canada

Identification of immune cells trafficking in gingival lymphatic vessels to afferent lymph nodes during development of periodontal disease.

Lymphatic vessels are made for transportation of tissue fluid, extravasated protein and they have an important role in the body's immune defense: activated antigen presenting cells enter the initial lymphatics and are transported to lymph nodes where they stimulate T and B lymphocytes targeted f...

Tildelt: kr 0,24 mill.

Prosjektperiode: 2009-2010

Sted: Vestland

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