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Dato fra ny til gammel

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Molecular labels that instruct specific synapse formation

One of the major questions within the field of Molecular Neuroscience is how different neurons are able to locate and form synapses specifically with their appropriate targets so that functional neural circuits are generated. Two quite different mechanis ms appear to be involved. One is an activ...

Tildelt: kr 42 999

Prosjektperiode: 2009-2009

Sted: Oslo

KLINISK-Klinisk forskning

Nutrition, growth and cogntive developement among very preterm infants

Basert på våre og andres tidligere studier er det mye som tyder på at svært premature barn får for liten tilførsel av mange viktige næringsstoffer rett etter fødselen. Til tross for at anbefalingene om næringsstofftilførsel har vært meget høye, er det ikke publisert studier som viser effekt av hø...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Properties of thin, unmyelinated axons in mammalian brain

In order to better understand and control how neurons work we need more knowledge about thin, unmyelinated axons. This is because: - They are the most common axonal type in the mammalian cortex. - They are the part of the neuron that we have least knowled ge about, which is mostly due to their ti...

Tildelt: kr 0,30 mill.

Prosjektperiode: 2008-2010

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Building national and international networks in aquaporin research: from in vivo two-photon imaging to gene analysis in patient cohorts

A number of neurological and psychiatric diseases for which current therapies are nonexisting or inadequate involve deficiencies in water homeostasis or cerebral blood flow regulation. Examples are headache disorders, epilepsy and Alzheimer`s disease. The recent Nobel-recognized discovery of aqu...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

IS-JSPS-JSPSmobilitet fra Japan

Sato, Toshihiko, JSPS-FY2008, short-term - Analysis of behavioural characteristics observed in children with developmental disorders

...

Tildelt: kr 38 725

Prosjektperiode: 2008-2008

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Receptors controlling the innate immune system

Myeloid cells are activated quickly at the start of an immune response and play a central role in the orchestration of the secondary, adaptive immune response. The adaptive response is influenced both indirectly, through the secretion of cytokines that re gulate the type of immune response genera...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Identification of plant foods and drinks available in the Norwegian marked that reduce oxidative stress and dampen inflammation

Oxidative stress is intimately involved in pathophysiology many chronic degenerative diseases such as cancer, cardiovascular diseases, diabetes, cataract as well as neurodegenerative diseases. Oxidative stress is also central to the theory of aging. We ar e therefore investigating the role of die...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Dietary antioxidants and oxidative stress: Novel technologies for assessing oxidative stress in blood samples

Tildelt: kr 3,1 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

STAMCELLER-Stamcelleforskning

Factors predicting graft-versus host disease after allogeneic hematopoietic stem cell transplantation.

Allogeneic stem cell transplantation (ASCTx) represents the most commonly applied therapeutic use of stem cells from born individuals. The mortality and complication rate of ASCT is high, often preventing its use in less severe conditions than cancer. Th e aim of this project is to generate a be...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging of dendritic activity in thalamic neurons by use of 2-photon technique

Processing of information in nerve cells occurs mainly in their dendrites. However, due to lack of adequate methods there is today very little information available on mechanisms of dendritic signal processing. New and powerful imaging techniques based o n 2-photon microscopy and calcium imaging...

Tildelt: kr 0,70 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Structural characterization of neural network alterations in transgenic rat model of Huntington's disease

Huntingtons disease (HD) is an untreatable inherited neurodegenerative disease causing motor and cognitive dysfunction and premature death, due to loss of specific neurons in the basal ganglia. Having access to the first transgenic rat model of HD, the pr esent project seeks to conduct the first ...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Oil induced autoimmune arthritis

We here present evidence that a novel class of genes encoding regulatory leukocytereceptors may be of clinical importance in autoimmune diseases elicited by environmental exposure to immunoadjuvants, in particular mineral oils. The evidence is based on th e structural identification of the rat Oi...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

IS-STP-Statsstipendprogram, utlendinger

Corcuera Martinez, Spania stp 07/08

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Tildelt: kr 30 000

Prosjektperiode: 2007-2007

Sted: Oslo

TU-Tungt utstyr

Optisk måling av dendrittisk signalbehandling i thalamiske nevroner ved bruk av 2-foton mikroskopi

Informasjonsbearbeidingen i nevroner foregår i hovedsak i dendrittiske strukturer, men mangel på adekvate teknikker har gjort at vi vet lite om hvordan signalbehandlingen i dendrittene faktisk foregår. Nye optiske teknikker basert på 2-foton mikroskopi h ar imidlertid nå åpnet for direkte studie...

Tildelt: kr 1,2 mill.

Prosjektperiode: 2007-2007

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Statistical modelling for infectious disease

We want to build a viable research group in statistical and mathematical modelling of infectious disease. We wish to make important original contributions to statistical methodology for analysis on infectious disease data, for the further purpose of aidin g, monitoring and understanding the sprea...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Astrocytes - guardians of neuroprotection

Astrocytes are the most abundant cell type in the human cerebral cortex but the focus on these cell types have been far neglected. In the later years it has become apparent that they play important roles in the homeostasis of the brain and evidence now al so suggests that they are essential compo...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

STAMCELLER-Stamcelleforskning

Genome plasticity of somatic stem cells

Chromatin organization in stem cells arises from distinct combinations of epigenetic marks resulting in genomic plasticity. Mesenchymal stem cells (MSCs) have received intense attention due to their perceived potential use in regenerative medicine. Nothin g is known, however, on epigenetic marks ...

Tildelt: kr 4,9 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

The role of excitatory amino acid in Parkinson's disease

Parkinson's disease is characterised by death of dopamine containing neurons in the substantia nigra. Long term levo-dopa treatment has severe side effects and is potentially toxic for neurons. The need for alternative treatments in Parkinson's disease is urgent. To accomplish this, further rese...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular and cellular mechanisms of the hippocampal memory system studied by in vivo recording in behaving animals

A major challenge in neuroscience is to explain behaviour in terms of molecular, cellular and neuronal network mechanisms. We will study mechanisms of the medial temporal lobe memory system by in vivo recording of hippocampal single unit and neuronal netw ork activity (EEG) in freely mowing rats ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Non-invasive in vivo imaging of neural stem cells

Stem cell biology is one of the most closely followed developments in biomedicine today, since stem cells may provide the foundation for rational regenerative therapeutics with far-reaching implications in the health sector. The use of stem cells to gener ate new nerve cells has received particul...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Scandinavian Physiological Society's Congress 2007

The Scandinavian Physiological Society will hold its Congress for 2007 in Oslo from the 10th to the 12th of August. Here we apply for financial support to arrange this Congress.

Tildelt: kr 0,20 mill.

Prosjektperiode: 2007-2008

Sted: Oslo

FRIBIO-Biologi og biomedisin

The role of T cell specific adapter protein in T cell activation and autoimmunity

Genetic variation in genes controlling T cell activation may be responsible for individual differences in fine-tuning of the immune response. Such variability may account for part of the genetic susceptibility to develop autoimmune diseases. Having a majo r interest in elucidating the aetiology o...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Characterization of Novel Insulin Regulated Pathways in Fat Synthesis in Liver and Adipose Tissue

Diets rich in lipids and carbohydrates together with a lack of physical exercise predispose individuals to multifunctional diseases such as atherosclerosis, hyperlipidemia, obesity, insulin resistance and diabetes type 2. Fat metabolism and glucose homeos tasis are inherently related, and insulin...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Electrical signaling in thin dendrites and axons in the cortex

A major challenge in neuroscience is to understand the mechanisms of neuronal computation, much of which is carried out by electrical signals generated by ion channels in the cell membrane. Within the last decade, advances in patch-clamp and imaging techn iques have extended our knowledge of such...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Application to host the Norwegian national node of International Neuroinformatics Coordinating Facility (INCF-N)

Neuroinformatics is a new research area aimed at the development of neuroscience data- and knowledge bases, computational models, and analytical tools for the sharing, integration and analysis of experimental data. The International Neuroinformatics Coord inating Facility (INCF), where Norway is ...

Tildelt: kr 3,7 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

The properties of thin, unmyelinated axons in mammalian brain

In order to better understand and control how neurons work we need more knowledge about thin, unmyelinated axons because: * They are the most common, but yet the least studied axonal type in the mammalian cortex. * They are the most excitable part of the neuron and are, therefore, very important ...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

The effect of polychlorinated biphenyls and brominated flame retardants on dopaminergic systems. A possible explanation for toxic effects.

The proposed project is to study in what way both molecular mechanisms and electrophysiological responses induced by treatment with PCB and BFR will affect the phosphorylation pattern of glutamate receptors in defined brain regions in controls and mice wi th deletion of the DARPP-32 gene.

Tildelt: kr 2,1 mill.

Prosjektperiode: 2006-2014

Sted: Oslo

RUSMIDDEL-Rusmiddelforskning

Alcohol problems and depression: A 15-year longitudinal, nationwide study of mental health among Norwegian doctors.

Background: Concurrent depressive disorder and abuse of alcohol is common in the general population, and longitudinal studies that clarify this interplay over time and identify risk factors are highly required. Health care workers and in particular doctor s show high levels of depressive symptoms...

Tildelt: kr 4,2 mill.

Prosjektperiode: 2006-2012

Sted: Oslo

FOLKEHELSE-Folkehelse

Promoting healthy weight among school children

Increasing rates of overweight and obesity is seen as a major public health problem. In Norway, the prevalence of overweight and obesity among school children has increased during the past decade. While the aetiology of obesity is not fully understood, ch ildren are seen as key target groups for ...

Tildelt: kr 5,9 mill.

Prosjektperiode: 2006-2012

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Tracking and prediction of health-related behaviour and physiological risk factors: 27 years follow up of a prospective cohort study

Worldwide the prevalence of overweight and obesity have increased the last decades. Obesity is associated with increased mortality, reduced life expectancy and an increase in several chronic diseases. It is important to identify risk factors for obesity t o make effective prevention strategies. O...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

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