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Dato fra ny til gammel

FUGE-Funksjonell genomforskn.i Norg

Funksjonelle studier av genekspresjon in vivo ved inflammatoriske sykdommer

The Blomhoff group was deeply involved in the application of the FUGE platform on transgenic mice, and the organisation of the platform. The described project builds on the expertise offered by the FUGE platform. Hallmarks of inflammation include activa tion of gene expression through the trans...

Tildelt: kr 0,50 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional genomics of intracellular trafficking

A high proportion of the human genome encodes proteins that mediate or regulate intracellular membrane trafficking. Understanding the molecular basis of membrane trafficking is important for the design of novel macromolecular drugs, and our aim is to iden tify and characterize protein complexes t...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional studies of S100A4 - A Calcium-binding Protein with Metastasis-promoting Capacity

The calcium-binding protein S100A4 has convincingly been linked to the metastatic process, butt he exact mechanism of action is still unknown. The main purpose of the project is to study the molecular mechanisms behind some of the biological functions th at have been suggested tor the protein, a...

Tildelt: kr 7,3 mill.

Prosjektperiode: 2005-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Regulation of intracellular traffic by PI3P-binding proteins - a functional and ultrastructrural study

Many important cellular processes such as intracellular transport, signaling through growth hormone receptors, cell motility and apoptosis are regulated directly or indirectly by phosphatidylinositol (PI)-3-kinases. These kinases have different reaction products, one of these being PI-3-phosphat...

Tildelt: kr 7,6 mill.

Prosjektperiode: 2005-2009

Sted: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

Regulation and molecular functions of replication proteins

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Tildelt: kr 14,0 mill.

Prosjektperiode: 2004-2009

Sted: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

Knockout zebrafish (KO-ZFISH) model

The genome projects – from microorganisms to vertebrates and mammals – create huge amounts of undeciphered genetic information. This cumulated DNA sequence bank needs intelligent, but as simple as possible, model systems to turn the currency of genomics into functional genomics. Only in one ver...

Tildelt: kr 11,0 mill.

Prosjektperiode: 2004-2009

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

A functional genomics approach to the choregraphy of genomic maintenace.

Maintenance of the genome is essential for survival of individuals and species. Failure to maintain the genome results in intrauterine death, developmental defects, premature ageing, decreased resistance to infections and cancer. DNA repair processes are functionally linked in intricate networks,...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2004-2011

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Søknad om støtte til ESF 2005 European Functional Genomics Conference

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Tildelt: kr 0,34 mill.

Prosjektperiode: 2004-2007

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Gene repair by oxidative demethylation

We have recently discovered a novel mechanism for repair of alkylation damage in DNA, performed by the E.coli AlkB protein, and also by human AlkB homologues. This repair function involves the demethylation of 1-methyladenine and 3-methylcytosine lesions discoveries have opened up many interest...

Tildelt: kr 6,9 mill.

Prosjektperiode: 2004-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Biobanks: The status and construction of informed consent

The project will study how informed consent, in the context of biobanks, is interpreted and infused with meaning. Informed consent is a central part of the legal regulation of medical practice and research. To many thi consept has become the key to brid ging the gap between experts and lay peop...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2004-2008

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Identifying genetic markers for quality traits in farmed cod; Additional funding of the EU project SEAFOODplus

SEAFOODplus is granted under Priority 5 in EU FP6, but are facing a 46% reduction of the budget to meet the allocation from EU. In RTD pillar 5 'Seafood from Aquaculture' several of the research blocks will identify the genetical basis for fish quality, i ncluding both flesh quality and ethical q...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2004-2007

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Mutant p53 as a target for improved cancer treatment

This project is a multi-disciplinary approach to explore and exploit the contribution of mutp53 to cancer. We will investigate in depth the molecular properties of mutp53: structural studies will pinpoint the changes that particular mutations inflict on t he structure of p53, and allow the classi...

Tildelt: kr 0,59 mill.

Prosjektperiode: 2004-2004

Sted: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

Novel signalling disruptors and enhancers that affect function of the cAMP signalling pathway

This Proposal outlines plans for further development of a research group competing at an international level in the field of cell signalling. The group employs functional genomics and platform technologies in the national FUGE programme to identify new genes implicated in specific pathways and ne...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2004-2007

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Transgenic models in neuroscience: Uncovering the secrets of the hippocampal formation

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Tildelt: kr 8,0 mill.

Prosjektperiode: 2004-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional genomics of antioxidant defence mechanisms and DNA repair: Relevance for aging and neurological disease.

The present prosject seeks to bring together a range of novel technologies and multidisciplinary expertise to broaden our understanding of DNA repair mechanisms. Specifically we will explore the hypothesis that deficient DNA repair plays a key pathogenet ic role in neurological disease and in ag...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2004-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Protein-protein interactions between infectious pancras virus proteins and host protein

In the post-genomic area new approaches have been developed to study and characterize protein functions in cells and organisms. One such strategy is the yeast two-hybrid system that can be used to generate complete protein interactions maps. Infectious pancreatic necrosis is one o the most thre...

Tildelt: kr 7,4 mill.

Prosjektperiode: 2004-2009

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Development of new platform techology for molecular analysis

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Tildelt: kr 1,7 mill.

Prosjektperiode: 2004-2006

Sted: Vestfold

FUGE-Funksjonell genomforskn.i Norg

Functional genomics in the salmon louse (Crustacea, Copepoda) by insertional mutagenesis and RNAi. SAMFIN. 164285

Transgenic oragnisms are one of the most powerful techniques for functional studies. By utilising a pantropic retroviral vector containing a green florescence reporter gene, transgenic specimens are easy to identify. Following breeding to homozygosity, abnormal phenotypes may appear. in collab...

Tildelt: kr 3,8 mill.

Prosjektperiode: 2004-2008

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Functional genomics studied by modern mass spectrometry

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Tildelt: kr 7,4 mill.

Prosjektperiode: 2004-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Mapping the language of research-biobanks and health registries: From traditional biobanking to research biobanking

The aim of the project is to investigate some of the ethical, legal and social challenges raised by reseach biobanking in its different moderen forms and formats. Besides analysing current legislation, other forms of regulation and public debates concern ing biobanks in European and other elevan...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2004-2007

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Nuclear program in health and disease - transcriptome approach to mechanisms

A central theme in the post-genomic era is to understand the fine-tuned symphony of gene expression. Transcription is the first and critical step of molecular events that turns the genome into a functional genome and weaves together target genes in coreg ulated cellular programs. In fact, many ...

Tildelt: kr 12,0 mill.

Prosjektperiode: 2004-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Envision - A molecular descriptor database and visualization tool for structural analysis of environmental adapted marine enzymes.

The project aims at building bioinformatics tools for identification, exploration and development of macromolecules of industrial and biotechnological importance. this will be achieved by developing methods and algorithms for identification of structural descriptors for a number of protein func...

Tildelt: kr 6,6 mill.

Prosjektperiode: 2004-2008

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Analysis of functional genes influencing fertility in cattle: Identification of candidate loci influencing fertility by integration of pheo

In this application, BoviBank Ltd. with partners propose a project taking advantage of the bovne biobank resources licenced to the former. The biobank will be explored by the most advanced genome tools available. Functional genes influencing fertility w ill be sought after by a combined approac...

Tildelt: kr 6,4 mill.

Prosjektperiode: 2004-2008

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

Functional Genomics in Zebrafish

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Tildelt: kr 1,6 mill.

Prosjektperiode: 2004-2006

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Søknad om regionale midler for FUGE Nord-Norge (Tilleggsbev. til prosjekt 152319/150)

Det administrative og strategiske arbeidet i den regionale faggruppen for FUGE Nord-Norge (FUGE-N) er formelt organisert i form av en overordnet styringsgruppe og underordnede brukerråd innen bioinformatikk, genomikk, proteomikk og strukturbiologi. I det te samarbeidet inngå representanter fra U...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2003-2006

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Structure and function of lipid rafts; investigating the role of membrane microdomains in cellular signalling

Biological membranes are no longer considered as homogenous fluid structures with embedded proteins; rather, the have been shown to contain microdimains or lipid rafts that function as platforms for co-ordination, organisation adn assembly of proteins inv olved in cellular processes such as signa...

Tildelt: kr 6,2 mill.

Prosjektperiode: 2003-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Immunoproteomics: Development of new cancer diagnostics and therapeutics by using the immunogenic part of the cancer proteome

Antibodies are long known to be valuable tools for cancer diagnostic. Within the last few yeard, the first antibodies for cancer therapy use have been introduced to the market with excellent results, and possibilities for developing cancer vaccines are w ithin reach. However, identifying tumour...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2003-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Strategies and regulations pertaining to access to genetic resources

The aim of the project is to develop a basis for a national and international regulation of access aquatic genetic resources for breeding and equitable sharing of the benefits rising from such use. By combining law, biology, and political science, the pr oject will aquire systematic knowledge on...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2003-2008

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

FUGE- Bergen Regional Application (Tilleggbev. til prosjekt 152323/150)

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Tildelt: kr 1,8 mill.

Prosjektperiode: 2003-2006

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

FUGE- Midt-regionen Søknad om regional støtte (Tilleggsbev. til prosjekt 152324/150)

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Tildelt: kr 1,4 mill.

Prosjektperiode: 2003-2009

Sted: Trøndelag - Trööndelage

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