301 antall prosjekter

Dato fra ny til gammel

FRIBIO-Biologi og biomedisin

Role of stromal cells in normal and pathological tissue homeostasis

The focus of this application is to study how the extracellular matrix can influence transcapillary transport of water and protein. The aim of this specific project is to develop an in vitro model system of loose connective tissue which can work in close parallel to our in vivo experiments. The u...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

FRIBIO-Biologi og biomedisin

Global expression of defence-related genes in Populus and transfer of knowledge to Norway spruce

Due to the great economic losses caused by the root and butt-rot pathogen Heterobasidion annosum, developments of efficient control measures are warranted. Considerable clonal variation has been recorded for Norway spruce in resistance towards H. annosum, but the defence mechanisms contributing ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Akershus

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Potential clinical relevance of radiation-induced signaling pathways

Radiation therapy is a commonly used treatment modality for cancer. Although in the past decades radiation therapy has shown to be a very successful treatment form, it still can be improved. One problem is that some tumors are particularly resistant to th e cytotoxic effects of radiation and resp...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

FRIBIO-Biologi og biomedisin

Oil induced autoimmune arthritis

We here present evidence that a novel class of genes encoding regulatory leukocytereceptors may be of clinical importance in autoimmune diseases elicited by environmental exposure to immunoadjuvants, in particular mineral oils. The evidence is based on th e structural identification of the rat Oi...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Interactions between brood parasites and their hosts in a heterogeneous landscape

Brood parasites and their hosts represent particularly suitable systems for studying the process of coevolution. A number of adaptations and counter-adaptations in hosts and parasites have previously been revealed, but few studies have considered dynamics between and within several host-parasite...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2007-2010

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The role of mismatch repair proteins in origin sequestration

We have shown that DNA replication is tightly coupled to cell growth in wild type E. coli cells. Initiation of replication occurs precisely at the same point in the cell cycle, generation after generation. The molecular mechanisms behind the precise timin g of initiation of replication are not ye...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2007-2014

Sted: Oslo

FRIBIO-Biologi og biomedisin

Modeling human disease in mice;DNA repair and genomic (in)stability.

Our research is currently focused on two classes of enzymes involved in repair, and possible regulation, of DNA and RNA species; flap endonuclease 1 (FEN1) and mammalian alkB homologs (ABHs). Genetic models are generated in order to elucidate the contribu tion of single gene deletions in genomic ...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The life history trade-off between immune function and brain development

As immunity has been proven to be costly in energetic terms, these investments are likely to conflict with other, important and energy-demanding fitness traits. Several studies have addressed trade-offs between the immune-system and other factors, like gr owth, development or reproductive investm...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2007-2012

Sted: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Applying advanced computational and experimental tools to explore surface electrostatics in chitinases

Understanding how proteins work is a major challenge in the post-genome era. Traditionally proteins have been studied by the use of numerous biochemical techniques, but as the number of proteins that needs to be characterized has increased, so has the num ber of in computo techniques to study pro...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2007-2012

Sted: Akershus

FRIBIO-Biologi og biomedisin

The early stages of adaptive divergence: the speed of evolution

In this proposed project we will study processes during the early phase of adaptive divergence. Lesjaskogsvatnet was colonized by grayling Thymallus thymallus in 1880 and during 120 years more than 20 demes have been established. Owing to profound tempera ture differences among tributaries, we ex...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Astrocytes - guardians of neuroprotection

Astrocytes are the most abundant cell type in the human cerebral cortex but the focus on these cell types have been far neglected. In the later years it has become apparent that they play important roles in the homeostasis of the brain and evidence now al so suggests that they are essential compo...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Molecular control of differentiation of multipotent stem cells in simple marine animals

The maintenance of stem cells and the regulation of their differentiation are still poorly understood. Interstitial stem cells are easily accessible in the simple animal Hydra and give rise to different neuronal cell fates, gametes and gland cells. In con trast, no interstitial stem cells have be...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2013

Sted: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Contact meeting for the Norwegian Biochemical Society

The annual meeting of the Norwegian Biochemical Society has a world-wide reputation as an excellent meeting place for scientists, both on the scientific and the social level. They have been a tremendous success and is arguably the one meeting in Norway wh ich has contributed the most to the conta...

Tildelt: kr 0,36 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Does ovarian fluid favour MHC-dissimilar sperm?

When males provide nothing but genes, female choice of mates is expected to favour individuals that can best increase offspring survival. This selection process may not only occur at an individual level, but also on the gamete level. Recent studies have i ndicated that the ova may select sperm on...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2007-2010

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The role of T cell specific adapter protein in T cell activation and autoimmunity

Genetic variation in genes controlling T cell activation may be responsible for individual differences in fine-tuning of the immune response. Such variability may account for part of the genetic susceptibility to develop autoimmune diseases. Having a majo r interest in elucidating the aetiology o...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Life history patterns in large carnivores and their application for management and conservation.

Life-history is an organism's pattern of growth, reproduction and mortality, formed by long-term evolutionary processes and by immediate responses to the environment. This project has 3 main objectives: 1) evaluate the patterns of lifetime reproductive su ccess of male and female brown bears; 2) ...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2007-2011

Sted: Akershus

FRIBIO-Biologi og biomedisin

Characterization of Novel Insulin Regulated Pathways in Fat Synthesis in Liver and Adipose Tissue

Diets rich in lipids and carbohydrates together with a lack of physical exercise predispose individuals to multifunctional diseases such as atherosclerosis, hyperlipidemia, obesity, insulin resistance and diabetes type 2. Fat metabolism and glucose homeos tasis are inherently related, and insulin...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The ecological and evolutionary significance of seed banks in Arabidopsis thaliana

Many studies of the genetic structuring of annual, selfing Arabidopsis thaliana populations on various geographical scales have been performed in recent years. Some studies conclude that local populations may contain relatively high amounts of genetic var iability both in phenotypic traits and pu...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2012

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

The role of normal neighbouring keratinocytes and fibroblasts on clonal expansion of oral cancer (stem) cells

Recent studies, including ours, have shown that the invasive behaviour of cancer cells is not solely due to mechanisms intrinsic to the individual tumour cell. Genetic changes of individual cells in a specific tissue are not sufficient for invasive cancer to develop. Rather, there is a vivid cro...

Tildelt: kr 1,1 mill.

Prosjektperiode: 2007-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

Electrical signaling in thin dendrites and axons in the cortex

A major challenge in neuroscience is to understand the mechanisms of neuronal computation, much of which is carried out by electrical signals generated by ion channels in the cell membrane. Within the last decade, advances in patch-clamp and imaging techn iques have extended our knowledge of such...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Functions of hippocampus and entorhinal cortex studied with viral vectors

Modern brain imaging methods have contributed enormously to contemporary knowledge about the particular brain systems involved in specific cognitive functions. Unfortunately, mechanistic insights have lagged behind, largely because brain mapping in humans lacks the spatial resolution required to...

Tildelt: kr 1,5 mill.

Prosjektperiode: 2007-2009

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Entorhinal grid cells and hippocampal memory

More than 30 years of research have pointed to the hippocampus as a key component of the brain's circuit for spatial representation. Although place-specific firing is undoubtedly the most conspicuous behavioural correlate of hippocampal principal neurons, hippocampal neurons also respond to a va...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2007-2009

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

The role of excitatory amino acid in Parkinson's disease

Parkinson's disease is characterised by death of dopamine containing neurons in the substantia nigra. Long term levo-dopa treatment has severe side effects and is potentially toxic for neurons. The need for alternative treatments in Parkinson's disease is urgent. To accomplish this, further rese...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Molecular and cellular mechanisms of the hippocampal memory system studied by in vivo recording in behaving animals

A major challenge in neuroscience is to explain behaviour in terms of molecular, cellular and neuronal network mechanisms. We will study mechanisms of the medial temporal lobe memory system by in vivo recording of hippocampal single unit and neuronal netw ork activity (EEG) in freely mowing rats ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

FRIBIO-Biologi og biomedisin

Study of cellular distribution and biological functions of neonatal Fc receptor in immune cells

Immunoglobulin G (IgG) is the major class of immunoglobulins and the protein with the longest serum half-life. IgG is also actively transferred to the fetus, giving the full-term fetus IgG levels over maternal levels and protective immunity. The MHC class I related neonatal Fc receptor (FcRn) is...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Quantification and Characterization of Microbial Communities in Air.

There is a serious lack of knowledge concerning the presence, activity and dispersal of airborne microorganisms. Most studies describing the prevalence of airborne microorganisms have only applied traditional microbiological methods and evaluated the occu rrence of culturable bacteria, which is k...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

Mechanism of cargo selectivity in axonal transport Isolation and characterization of kinesin light chain associated vesicles

The aim of this project is to gain knowledge about how the motor protein kinesin-I interacts with its vesicle cargo, and what the nature is of the vesicles that are transported by kinesin-I through neurons. The role of neuronal transport in neurodegenerat ive diseases such as Alzheimer's disease,...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Dynamics of synaptic transmission in the rod pathway of the retina

A considerable challenge in neuroscientific research is to explain processes at the systems level in terms of mechanisms at cellular and molecular levels. The retina serves as an ideal model system amenable to experimental approaches that directly aim to bridge this gap. With respect to the senso...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

FRIBIO-Biologi og biomedisin

Fe-S Cluster Biogenesis in Plastids and Mitochondria in Plants

Iron-sulfur (Fe-S) clusters are essential, inorganic cofactors of Fe-S proteins involved in numerous vital developmental processes. Although simple in structure Fe-S clusters are not formed spontaneously but require an intricate interplay of a number of p roteins and in plants Fe-S cluster biogen...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2010

Sted: Rogaland

FRIBIO-Biologi og biomedisin

Dynamics underlying astrocyte behaviour

For a long time astrocytes, the most abundant glial cell species, have been considered passive bystanders of neural activity. The picture that is now emerging is that astrocytes are critically involved in regulating brain function. Despite extensive exper imental efforts, a thorough understanding...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2009

Sted: Akershus

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