301 antall prosjekter

Dato fra ny til gammel

FRIBIO-Biologi og biomedisin

Dynamics of synaptic transmission in the rod pathway of the retina

A considerable challenge in neuroscientific research is to explain processes at the systems level in terms of mechanisms at cellular and molecular levels. The retina serves as an ideal model system amenable to experimental approaches that directly aim to bridge this gap. With respect to the senso...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Molecular and cellular mechanisms of the hippocampal memory system studied by in vivo recording in behaving animals

A major challenge in neuroscience is to explain behaviour in terms of molecular, cellular and neuronal network mechanisms. We will study mechanisms of the medial temporal lobe memory system by in vivo recording of hippocampal single unit and neuronal netw ork activity (EEG) in freely mowing rats ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

FRIBIO-Biologi og biomedisin

Vaccine development for HIV and influenza

Aim: Based on the vaccibody principle developed by us, we wish to generate novel vaccines for important infectious diseases such as HIV and influenza. Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However , for some important diseases such as HIV...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Contact meeting for the Norwegian Biochemical Society

The annual meeting of the Norwegian Biochemical Society has a world-wide reputation as an excellent meeting place for scientists, both on the scientific and the social level. They have been a tremendous success and is arguably the one meeting in Norway wh ich has contributed the most to the conta...

Tildelt: kr 0,36 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

EGF-induced Formation of Clathrin Coated Pits

Growth factor receptors control cellular growth and differentiation by transmitting signals from outside the cell to the cell interior, particularly the nucleus. Signal transmission can be modulated in several ways. To control signalling, down-regulation of receptors from the cell surface is impo...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Does ovarian fluid favour MHC-dissimilar sperm?

When males provide nothing but genes, female choice of mates is expected to favour individuals that can best increase offspring survival. This selection process may not only occur at an individual level, but also on the gamete level. Recent studies have i ndicated that the ova may select sperm on...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2007-2010

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The role of T cell specific adapter protein in T cell activation and autoimmunity

Genetic variation in genes controlling T cell activation may be responsible for individual differences in fine-tuning of the immune response. Such variability may account for part of the genetic susceptibility to develop autoimmune diseases. Having a majo r interest in elucidating the aetiology o...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Life history patterns in large carnivores and their application for management and conservation.

Life-history is an organism's pattern of growth, reproduction and mortality, formed by long-term evolutionary processes and by immediate responses to the environment. This project has 3 main objectives: 1) evaluate the patterns of lifetime reproductive su ccess of male and female brown bears; 2) ...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2007-2011

Sted: Akershus

FRIBIO-Biologi og biomedisin

Characterization of Novel Insulin Regulated Pathways in Fat Synthesis in Liver and Adipose Tissue

Diets rich in lipids and carbohydrates together with a lack of physical exercise predispose individuals to multifunctional diseases such as atherosclerosis, hyperlipidemia, obesity, insulin resistance and diabetes type 2. Fat metabolism and glucose homeos tasis are inherently related, and insulin...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The ecological and evolutionary significance of seed banks in Arabidopsis thaliana

Many studies of the genetic structuring of annual, selfing Arabidopsis thaliana populations on various geographical scales have been performed in recent years. Some studies conclude that local populations may contain relatively high amounts of genetic var iability both in phenotypic traits and pu...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2012

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Fe-S Cluster Biogenesis in Plastids and Mitochondria in Plants

Iron-sulfur (Fe-S) clusters are essential, inorganic cofactors of Fe-S proteins involved in numerous vital developmental processes. Although simple in structure Fe-S clusters are not formed spontaneously but require an intricate interplay of a number of p roteins and in plants Fe-S cluster biogen...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2010

Sted: Rogaland

FRIBIO-Biologi og biomedisin

Dynamics underlying astrocyte behaviour

For a long time astrocytes, the most abundant glial cell species, have been considered passive bystanders of neural activity. The picture that is now emerging is that astrocytes are critically involved in regulating brain function. Despite extensive exper imental efforts, a thorough understanding...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2009

Sted: Akershus

FRIBIO-Biologi og biomedisin

Functional genetic networks that maintain genomic stability in mammalian cell lines and in Caenorhabditis elegans

The spontaneous formation of lesions in DNA is among the most significant threats to genomic integrity. We are using genetic and biochemical methods in the model organism Caenorhabditis elegans (C.elegans) and DNA repair deficient mouse cell lines to stud y the biological consequences of accumula...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Interplay between DNA repair mechanisms in yeast and their crosstalk with other cellular processes

DNA repair is essential for the maintenance of genomic integrity and defect repair is associated with diseases as cancer, neurological disorders and aging. Unraveling the mechanism of DNA repair is therefore of fundamental importance and the present proje ct seeks to broaden our understanding of ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Studies of growth control and gene expression in normal and neoplastic B-lymphoid cells

Malignant lymphomas represent a heterogeneous group of diseases with variable clinical course. The complex biology and the variety of genetic and epigenetic factors involved in the pathogenesis make lymphomas a challenging disease for translational resear ch. There a clear need for the developmen...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2006-2012

Sted: Oslo

FRIBIO-Biologi og biomedisin

Endocytosis and intracellular transport of protein toxins

Errors in trafficking and signalling are associated with different diseases, including cancer. This project aims at increasing our knowledge about intracellular transport processes to provide a more rational basis for treatment and prevention of disease. Protein toxins such as Shiga toxin and the...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

The properties of thin, unmyelinated axons in mammalian brain

In order to better understand and control how neurons work we need more knowledge about thin, unmyelinated axons because: * They are the most common, but yet the least studied axonal type in the mammalian cortex. * They are the most excitable part of the neuron and are, therefore, very important ...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Spatiotemporal dynamics of introduced bark beetles: resource competition, invasion risk and management

The movement and establishment of invasive species in new habitats is a global economic and ecological problem. The increased trade among countries and continents has increased the chances of introductions of new species. Once alien pest species have beco me established in their new habitats, the...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

FRIBIO-Biologi og biomedisin

Chromatin and differential gene regulation: The role of adjacent PHD fingers and bromo domains in epigenetic regulators

Correct differential gene expression is essential for proper development of tissues and organs. While the initial patterns of gene expression are established by classical transcription factors, the maintenance of correct gene expression relies on epigenet ic mechanisms, one of which relies on dif...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2006-2011

Sted: Vestland

FRIBIO-Biologi og biomedisin

Functional characterisation of AlkB-like macromolecular demethylases

We have recently discovered a novel mechanism for repairing methylation damage in DNA and RNA. The repair reaction occurs by oxidative demethylation, and can be performed both by human and bacterial AlkB proteins. Eight different AlkB-like proteins are fo und in the human genome, and the project ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

NEURONES FORMING FUNCTIONAL NETWORKS IN THE MOTH BRAIN

We are searching to uncover the neuronal network involved in chemosensory coding and appetitive learning in insects, using moths of the subfamily Heliothinae as model organisms. The focus in the present project is to characterise physiologically and morph ologically neurones in the primary and th...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2006-2009

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Protein - DNA interactions at atomic levels

The project aims at exploring protein-DNA interactions at atomic levels using novel DNA-binding proteins. Protein targets will be selected from the genomes of the extremophiles Deinococcus radiodurans and Vibrio salmonicida and produced recombinant in qua ntities necessary for structural and func...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2011

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The study of translocation of extragenous growth factors into cells- mechanisms and biological function of intracellular growth factors.

The growth, development and repair of cells and organs are controlled by a variety of hormones, growth factors and cytokines. Many of these factors are proteins that bind to specific molecules (receptors) at the cell surface. These receptors reside in the plasma membrane. Lipid membranes control...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Surviving without oxygen - from heart function to DNA replication

While most vertebrates die within minutes of anoxia (no oxygen), a few species can tolerate anoxia about 1000 times longer. These include the crucian carp (Carassius carassius, No: karuss), a common fish in Norway, and some turtles. Anoxia and ischemia related diseases are the major killers in ...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Modulation of a PKA-Csk-Lck inhibitory pathway in T cell lipid rafts by CD28-mediated recruitment of a b-arrestin/phosphodiesterase complex

The goal of this project is to understand the molecular mechanisms for cAMP inhibition of lymphocyte proliferation and immune functions. Specifically, we want to understand the molecular interactions and spatio-temporal regulation of the newly mapped PKA- type I-Csk inhibitory pathway regulating ...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Molecular Pathogenetic Mechanisms of Heart Failure - Dissecting GRK Function in The Heart

Heart failure, the final outcome of many cardiovascular disorders, is a major cause of morbidity and mortality in the Western Hemisphere. Indeed, the incidence and prevalence of heart failure in the Western Hemisphere are increasing due to altered demogra phics with increased proportion of elderl...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

The role of regulatory T cells in allergy

A dramatic increase in prevalence of allergy observed within the last two decades has been associated with better hygiene, increased use of antibiotics and improved vaccination. Infections are important for the induction of regulatory elements within the immune system, and it has been suggested t...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Degradation of insoluble carbohydrate polymers: how do microbial chitinolytic machineries work?

Enzymatic degradation of abundant insoluble carbohydrate polymers such as cellulose and chitin is of tremendous biological and biotechnological importance. Microbes produce numerous enzymes to hydrolyze these polymers, but the question of how they manage to disrupt the crystalline structure of th...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2009

Sted: Akershus

FRIBIO-Biologi og biomedisin

Cascading Effects of Mutualistic Interactions: From Insect Flower Visitation to Plant Community Dynamics

Ecologists have for a long time been interested in how negative plant-animal interactions, such as herbivory and seed predation affect the population dynamics of plant species, their distribution on small and large spatial scales, and the plant community species composition and diversity. Positiv...

Tildelt: kr 4,4 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

FRIBIO-Biologi og biomedisin

Sperm morphology and function in passerine birds

The prime function of sperm cells is to fertilize eggs. Despite this common purpose, there is a tremendous diversity among animal taxa in sperm phenotypes. Part of the variation can be attributed to phylogenetic relatedness, and sperm are often used as di agnostic traits in taxonomy. But there is...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

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