251 antall prosjekter

Dato fra ny til gammel

FUGE-Funksjonell genomforskn.i Norg

Genome sequencing of cod by exclusive use of ultra-high-throughput sequencing technology

We propose a project characterized by exclusive use of new ultra-high-throughput sequencing technology combined with state-of-the art bioinformatics algorithms designed for maximal exploitation of this technology. The project will be carried out in close collaboration with 454 Life Sciences, the...

Tildelt: kr 10,0 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Information material for public health care professionals

We would like to produce information material for physicians, midwives and other health care workers who meet the couples before, during and after their pregnancy. We would like to make information folders and also write in journals read by the health car e professionals. We would also like to ma...

Tildelt: kr 0,15 mill.

Prosjektperiode: 2008-2010

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Identification of key antiviral and inflammatory modulators in Atlantic cod (Gadus morhua L.)

Atlantic cod has recently been introduced into aquaculture in Norway and is expected to constitute a major part of Norwegian fish farming within few years. Expansion of this industry faces many challenges, including disease problems. From farming of salmo nids we know that vaccination has been a ...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2008-2011

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

An integrative genomics approach to identify genes and biochemical pathways underlying complex traits in Atlantic salmon

Identifying the genes and biochemical pathways in salmon that are responsible for economically important traits is the primary focus of this application. While a wealth of phenotypic data is available (e.g. the salmon biobank) the ability to resolve causa tive genes and loci has been technology l...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2008-2012

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

Tissue Factor siRNA for treatment of melanoma metastasis

The project described herein covers the research and initial preclinical part of the project of developing a drug based on small interfering RNAs (siRNA) targeting Tissue Factor, a molecule known to be involved in the processes of blood clotting, metastas is and angiogenesis. The project has emph...

Tildelt: kr 1,9 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Development of a male contraceptive - from hit to drug candidate

The primary objective of the present project is to perform a hit-to-lead program (H2L) and further to develop a preclinical drug candidate. The outcome of the project is expected to be a preclinical drug candidate. Lead-backups will also be secured in cas e of future failure in a downstream proce...

Tildelt: kr 4,9 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Bioinformatics platform for the pharmacogenomic analysis of sequence variation in complex diseases

Traditional studies of complex disease and drug response have utilized a one gene one drug strategy. However because of highthroughput technology , the future trend of personalized medicine lies in understanding and modulating the complex responses involv ing many genes, their sequence variation ...

Tildelt: kr 3,5 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Developing the next generation of oral vaccines for salmonids using plastids in plants

The following programme will develop a new concept of oral vaccines for fish using plastids as bio-factories in plants. The technology will allow the insertion of any gene or combination of genes into a plant plastid genome, resulting in a high level prot ein expression (approx 20% of total cellu...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2008-2012

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors (TcRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cell s that recognize common cancer proteins, ...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Host-virus interactions in Atlantic salmon

Infectious pancreatic necrosis virus (IPNV) and infectious salmon anemia virus (ISAV) are viruses causing threatening diseases in Norwegian aquaculture. Certainly, one of the most challenging problems in designing control strategies against these viruses is to define the specific factors, both in...

Tildelt: kr 12,0 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Population-based cohorts and biobanks in Norway. A national consortium for research on genes, environment and health

The Biohealth 2 proposal is based on CONOR (Cohort of Norway) and MoBa (the Norwegian Mother and Child Cohort Study), which together formed BioHealth 1 (Biobanks for Health in Norway). BioHealth I was funded by FUGE I and has five partners: the universiti es in Tromsø (UiT), Bergen (UiB) and Oslo...

Tildelt: kr 19,6 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Stroma-targeting: a directed approached aimed at tumor stroma fibroblasts

In recent years the awareness about the importance of the stroma for normal tissue homeostasis and tumor growth has increased. Much of this progress has been in the field of angiogenesis and anti-angiogenesis approaches are currently receiving considerabl e attention. In contrast to the recent fo...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2008-2013

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

A novel checkpoint regulating the cell cycle of fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle. Cancer development is frequently associated with the lack of checkpoints an...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Norwegian Molecular Imaging Consortium - Subnode: Subcellular interactions and imaging - NTNU

Knowledge about protein-protein interactions as well as interactions between other molecules is of critical importance for functional genomics. By providing the state-of-the-art technologies to study inter-and intramolecular interactions, the national res earch community will be able to move func...

Tildelt: kr 7,4 mill.

Prosjektperiode: 2008-2013

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

A National Service Platform for Global Analysis of Genome Structure and Function. The Norwegian Microarray Consortium (NMC)

The FUGE Microarray Platform is run by the Norwegian Microarray Consortium (NMC), based on a formal institutional collaboration between RR/UiO, NTNU, and UiB. We offer in-house production of standard and custom arrays, expression and genomic profiling ser vices (RNA or DNA in-DATA out) with diffe...

Tildelt: kr 9,7 mill.

Prosjektperiode: 2008-2013

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Aleström Zebrafish Lab - activities beyond the research projects 2007-2011

The major focus of the AZLab services are two-fold: 1) Being a regional center, in an national and international network of transgenic zebrafish laboratories, with capacity to offer access to the zebrafish model for academic and commercial partners. 2) Es tablish a unique training program in zebr...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2008-2012

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

Translational Research in Lung Cancer and Palliative Care - from genomics to symptom control

This project will perform functional genomic research with a translational approach that will bring new scientific knowledge into the health care system. The project will identify gene polymorphisms and gene expression profiles that may confer developmen t of lung cancer, and act as a prognostic...

Tildelt: kr 9,3 mill.

Prosjektperiode: 2008-2012

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The Proteomics Core Facility at the University of Tromsø as a node in the national consortium of proteomics platforms (NorProteomics)

The core facility for Proteomics in Tromsø has been fully operational since the end of 2004. The main purpose of the facility has been to serve research labs in the FUGE North region. The facility has 3 Mass spectrometer systems from Waters/Micromass. A M ALDI Micro MX, a Q-TOF Ultima Global with...

Tildelt: kr 1,3 mill.

Prosjektperiode: 2008-2012

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Channel 2 application for continuation of FUGE MIC Trondheim in FUGE II period (2007-2011)

MIC Trondheim wants to continue in the FUGE II period with MR as the core technology, and will expand in capacity with acquisition of new MR equipment, and expand the high-level competence necessary for offering a wide variety of methods tailored to the u ser's research tasks. A goal is to establ...

Tildelt: kr 5,6 mill.

Prosjektperiode: 2008-2013

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

A FUGE Proteomics node at DMF, NTNU

Proteomics has become increasingly important within functional genomics to assess gene expression analyses, to identify biomarkers for disease, to understand how proteins functionally interact, and to identify post-translational modifications that drive the interactions and modify protein functi...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2008-2013

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

A NATIONAL SERVICE PLATFORM FOR GLOBAL ANALYSIS OF GENOME STRUCTURE AND FUNCTION: THE NORWEGIAN MICROARRAY CONSORTIUM

Tildelt: kr 10,0 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

The Bioinformatics Platform in the FUGE2 programme

The FUGE 2 Bioinformatics platform is designed in direct response to the demand for increased use of bioinformatics from the FUGE 1 evaluation. The platform will provide state of the art research based services in theoretical and applied bioinformatics to Norwegian research groups, in close coll...

Tildelt: kr 26,8 mill.

Prosjektperiode: 2008-2012

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Global gene expression of human and rat brain: an integrative genomics study of CNS functions and genetic susceptibility in schizophrenia

Schizophrenia (SCZ) is a serious psychotic disorder ranked among the 10 most disabilitating disesases worlwide (WHO) with a lifetime risk of 1% in the general population. Despite decades of research, the understanding of underlying biological mechanism re mains inadequate and fragmentary and trea...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2008-2012

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Protein-protein interactions at atomic levels

Our DNA is every day subjected to external and internal damaging agents and understanding the mechanisms of DNA repair at a molecular level is increasingly important in order to address future challenges for the human health. This project aims to reveal n ew information about molecular mechanisms...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2008-2014

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Membrane trafficking in immunity and tumour suppression

Intracellular membrane trafficking plays key roles in cell signalling and innate and adaptive immunity. Endocytosis and subsequent endolysosomal trafficking of growth factor receptors constitute a crucial mechanism for receptor signal attenuation and tumo ur suppression. For innate immunity again...

Tildelt: kr 10,0 mill.

Prosjektperiode: 2008-2012

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Towards personalized therapy for breast cancer

Purpose of the project: Few protocols have so far been designed with attempts to characterize the systems biology of cancer. The objective of the project is to translate information obtained from integrative molecular analysis of material collected from i ndividual cancer patients, through valida...

Tildelt: kr 10,0 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

A proteomics node at Ås campus

As part of the NorProteomics FUGE network, Ås campus will develop expertise in the areas listed below and make this expertise available to on-campus and off-campus projects. Our key areas are: 1. Proteomics in difficult matrices, primarily related to food chemistry (meat, cereals; i.e. analysis ...

Tildelt: kr 1,5 mill.

Prosjektperiode: 2008-2012

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

Ultra-high throughput sequencing platform

Recent technological breakthroughs making possible low cost ultra-high throughput gene sequencing (UTS) open up a new era within biology. It is now possible to sequence a bacterial genome in less than a week, a human chromosome in 3-4 weeks or generate m illions of metagenomic sequences in days....

Tildelt: kr 10,0 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Norwegian Proteomics Consortium - Bergen

PROBE, the Norwegian proteomic platform, was established in 2002 by the Norwegian Research Council under the Functional Genomics Initiative (FUGE) to provide the Norwegian scientific community access to the best in proteomic technologies and competence. Located within the Institute of Biomedicine...

Tildelt: kr 9,5 mill.

Prosjektperiode: 2008-2012

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

A FUGE Nor-MIC Node in Live Cell Imaging and Protein-Protein Interaction Analysis in Plants

There is a growing need to understand fundamental plant processes at the subcellular level. With respect to this it is of paramount importance to the Norwegian research community that a National Imaging Service and Training facility exists to meet these f uture demands. In addition a Molecular Im...

Tildelt: kr 1,0 mill.

Prosjektperiode: 2008-2012

Sted: Rogaland

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