0 antall prosjekter

Dato fra ny til gammel

FRIBIO-Biologi og biomedisin

Functional characterisation of AlkB-like macromolecular demethylases

We have recently discovered a novel mechanism for repairing methylation damage in DNA and RNA. The repair reaction occurs by oxidative demethylation, and can be performed both by human and bacterial AlkB proteins. Eight different AlkB-like proteins are fo und in the human genome, and the project ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Organic protein feed and edible oil from oilseed crops

Oilseed summary "Organic protein feed and edible oil from oilseed crops" is a four year research project with the aim of obtaining new knowledge for secure production of high-quality proteins for livestock feeds and edible oil for human consumption in No rwegian organic farming based on oilseed ...

Tildelt: kr 10,5 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

MILPAAHEL-Miljøpåvirkning og helse

The effect of polychlorinated biphenyls and brominated flame retardants on dopaminergic systems. A possible explanation for toxic effects.

The proposed project is to study in what way both molecular mechanisms and electrophysiological responses induced by treatment with PCB and BFR will affect the phosphorylation pattern of glutamate receptors in defined brain regions in controls and mice wi th deletion of the DARPP-32 gene.

Tildelt: kr 2,1 mill.

Prosjektperiode: 2006-2014

Sted: Oslo

FRIBIO-Biologi og biomedisin

NEURONES FORMING FUNCTIONAL NETWORKS IN THE MOTH BRAIN

We are searching to uncover the neuronal network involved in chemosensory coding and appetitive learning in insects, using moths of the subfamily Heliothinae as model organisms. The focus in the present project is to characterise physiologically and morph ologically neurones in the primary and th...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2006-2009

Sted: Trøndelag - Trööndelage

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Safe and cost-effective production of dry-cured meat with reduced mould growth

Mould contamination on dry-cured meat is periodically a significant quality problem leading to a major economic impact for the producers due to cleaning and loss of products. In addition the mould growth may represent a health risk for the staff due to th e allergenic potential of the moulds and ...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Biofilm, water quality and food production - Improving the water quality for prevention of food spoilage and foodborne diseases

Bacteria, moulds and yeasts constitute a great challenge and a significant quality problem for food industry, leading to a major economic impact for the producers due to cleaning, reduced shelf life and loss of products. Many foodborne pathogens are also waterborne pathogens. Increased knowledge ...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2006-2011

Sted: Akershus

BIONÆR-Bionæringsprogram

Optimal helse, velferd og mattrygghet for kvalitetsprodukter fra norske geiter.

Geiteprodukter har hatt framgang i Europa inkludert i våre naboland, de siste ti årene. Geitas fremtoning og spenstighet i forhold til andre dyr samt naturlig uteliv (beite) appellerer, og den positive holdningen til geita som husdyr smitter over på forbr ukernes holdninger og gir økt etterspørse...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2006-2013

Sted: Akershus

MATPROG-Matprogrammet: Norsk mat fra sjø og land

A genome expression profiling strategy towards better disease control and improved animal welfare

An immunogenetic approach to disease control strives to define genetic markers for susceptibility and/or resistance to diseases through identification of genes involved in immune function and immune regulation. Genetic factors regulating immune responses are essential for an animal?s ability to s...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

BIA-Brukerstyrt innovasjonsarena

Immunmodulatorer brukt som hjelpestoff ved immunterapeutisk behandling

Prosjektet bygger på omfattende studier i de siste 15 år av den sykdomsforebyggende virkning av immunstimulerende beta-glukaner. Grunnleggende forskning har klarlagt sammenhenger mellom kjemisk struktur og immunologisk virkning av denne stoffgruppen. Tekn ologisk utviklingsarbeid har gjort det mu...

Tildelt: kr 12,6 mill.

Prosjektperiode: 2006-2011

Sted: Troms - Romsa - Tromssa

BIA-Brukerstyrt innovasjonsarena

Development and testing of drug candidates for male contraceptives

This project is a drug discovery R&D effort aiming at developing and testing drug candidates for male contraceptives. The project will be performed in a collaboration between Spermatech AS, the University of Oslo, the Norwegian Biotechnology Center, the U niversity of Tromsø, and the National Hos...

Tildelt: kr 7,3 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

GLOBHELS-Global helse

Norwegian Forum for Global Health Research

According to the statutes the Forum shall promote high quality research and training aiming at improving health and health care for marginalized population groups in low- and middle-income countries. The main strategies applied to fulfill the objectives of the Forum include activities to: " Imp...

Tildelt: kr 1,9 mill.

Prosjektperiode: 2006-2013

Sted: Vestland

FRIBIO-Biologi og biomedisin

The study of translocation of extragenous growth factors into cells- mechanisms and biological function of intracellular growth factors.

The growth, development and repair of cells and organs are controlled by a variety of hormones, growth factors and cytokines. Many of these factors are proteins that bind to specific molecules (receptors) at the cell surface. These receptors reside in the plasma membrane. Lipid membranes control...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Surviving without oxygen - from heart function to DNA replication

While most vertebrates die within minutes of anoxia (no oxygen), a few species can tolerate anoxia about 1000 times longer. These include the crucian carp (Carassius carassius, No: karuss), a common fish in Norway, and some turtles. Anoxia and ischemia related diseases are the major killers in ...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

Utvikling av analysemetode/analysekit for påvisning av bakterier involvert ved patogenese av osteoartritt

Osteoartritt (OA) er en leddsykdom som rammer 7-8% av befolkningen i den industrialiserte verden. OA affiserer leddenes beskyttende brusklag, og bryter dette ned over tid. Årsaken(e) til OA er ikke kjent. Det finnes ingen effektiv metodikk for diagnose e ller behandling av sykdommen. Diagnostikk...

Tildelt: kr 9,7 mill.

Prosjektperiode: 2006-2010

Sted: Troms - Romsa - Tromssa

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Automatic Fish Fillet Inspection by Imaging Spectroscopy

The main objective of this project is to provide the Norwegian fish processing industry with a technological solution for automatic quality control in fish fillet production. Development of methods and tools will be based on the use of imaging spectroscop y. Quality features of fish fillets are ...

Tildelt: kr 7,9 mill.

Prosjektperiode: 2006-2010

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

The Systems Biology of Breast Cancer

Systems Biology of Breast Cancer creates a world-class cancer research team, working systematically towards understanding of the biological dynamics of breast cancer. Breast cancer is a genetic disease; breast tumor genomes are dynamic and tumors are com plex systems shaped by gene aberrations, ...

Tildelt: kr 9,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional Genomics of Regulatory T cells - Novel Therapeutic Strategies for Immunomodulation

The main goal of the research plan is to understand how the immune system controls immune reactivity and balances self-tolerance versus an efficient immune defence. This could potentially lead to new understanding of key factors in the pathogenesis of hum an disease. Specifically, we aim to inves...

Tildelt: kr 7,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

MILGENHEL-Miljø, gener og helse

Human exposure pathways of polyfluorinated compounds and brominated flame retardants used in consumer products as inputs to risk assessment

Recently, concerns have risen about the increasing occurrence of polyfluorinated alkyl compounds (PFCs) and brominated flame retardants (BFRs) in the environment, compounds that are widely used in consumer products. The exposure of humans to PFCs and BFRs and the potential associated health risk...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Protein - DNA interactions at atomic levels

The project aims at exploring protein-DNA interactions at atomic levels using novel DNA-binding proteins. Protein targets will be selected from the genomes of the extremophiles Deinococcus radiodurans and Vibrio salmonicida and produced recombinant in qua ntities necessary for structural and func...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2011

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Modulation of a PKA-Csk-Lck inhibitory pathway in T cell lipid rafts by CD28-mediated recruitment of a b-arrestin/phosphodiesterase complex

The goal of this project is to understand the molecular mechanisms for cAMP inhibition of lymphocyte proliferation and immune functions. Specifically, we want to understand the molecular interactions and spatio-temporal regulation of the newly mapped PKA- type I-Csk inhibitory pathway regulating ...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Molecular Pathogenetic Mechanisms of Heart Failure - Dissecting GRK Function in The Heart

Heart failure, the final outcome of many cardiovascular disorders, is a major cause of morbidity and mortality in the Western Hemisphere. Indeed, the incidence and prevalence of heart failure in the Western Hemisphere are increasing due to altered demogra phics with increased proportion of elderl...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Cellular Mechanisms Templating Complex Extracellular Structures via Cellulose Scaffolds: the Oikopleura House

Extracellular matrices are a fundamental interface through which cells and organisms interact with their external environment. In some cases very complex 3-dimensional structures are formed and the extracellular matrix of plants is crucial in effecting de velopmental pattern formation. Cellulose ...

Tildelt: kr 4,9 mill.

Prosjektperiode: 2006-2010

Sted: Vestland

KLINISK-Klinisk forskning

MOLECULAR MR IMAGING OF BREAST CANCER Treatment monitoring and prognostic evaluation

Successful cancer treatment and recovery depends upon early diagnosis, but also important is the decision on which type of treatment each cancer patient should receive. Through a combination of new contrast agents and improved technology, MR is making adv ances in identifying the functional and m...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2006-2010

Sted: Trøndelag - Trööndelage

MILGENHEL-Miljø, gener og helse

Aryl hydrocarbon receptor mediated responses to environmental toxicants

A group of environmental pollutants, which may pose a potential health risk to humans, is the polycyclic aromatic hydrocarbons (PAHs). PAHs are found in urban air and occupational environments, and a very large part of the population is exposed to these c ompounds. An important source of PAH expo...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

The role of regulatory T cells in allergy

A dramatic increase in prevalence of allergy observed within the last two decades has been associated with better hygiene, increased use of antibiotics and improved vaccination. Infections are important for the induction of regulatory elements within the immune system, and it has been suggested t...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Degradation of insoluble carbohydrate polymers: how do microbial chitinolytic machineries work?

Enzymatic degradation of abundant insoluble carbohydrate polymers such as cellulose and chitin is of tremendous biological and biotechnological importance. Microbes produce numerous enzymes to hydrolyze these polymers, but the question of how they manage to disrupt the crystalline structure of th...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2009

Sted: Akershus

HAVBRUKS-Havbruk - en næring i vekst

Nitric oxide regulation of development in fish: emphasis on the light-brain-pituitary axis and gill during salmon smoltification

Development of organs and tissues occur during critical periods throughout life. Specific systems develop at specific stages, e.g. early development (organogenesis) and smoltification (light-brain-pituitary axis (LBP) and gill). Our research has shown the LBP and gill undergo morphological, mole...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2006-2009

Sted: Vestland

HAVBRUKS-Havbruk - en næring i vekst

Novel strategies for immunisation against intracellular pathogens of Atlantic salmon

The aim of this project is to develop improved formulations and optimised antigen delivery strategies to elicit protective immune responses against intracellular pathogens of Atlantic salmon. The introduction of adjuvanted vaccines in the salmon industry over the last decade has been a key fact...

Tildelt: kr 6,5 mill.

Prosjektperiode: 2006-2010

Sted: Troms - Romsa - Tromssa

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Utnytting av molekylære metoder i miljøvennlig bekjempelse av sjukdommer i gulrot

Prosjektet omfatter optimal utnyttelse av bioteknologiske metoder (PCR) for å bekjempe plantesjukdommer i gulrot, som er en av de viktigste grønnsakvekstene i Norge med førstehåndsverdien på ca 150 mill. kr. årlig. Soppsjukdommer er årsak til store tap b åde under produksjon og omsetning av gulr...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2006-2009

Sted: Akershus

BIONÆR-Bionæringsprogram

Health promoting compounds in barley and oat

The project will focus on barley and oat, both cereals with substantial fibre, antioxidant and oligosaccharide levels. Milling and related processing will be performed under industrial or pilot-plant conditions using state-of-the-art technology with the p urpose of achieving fractions rich in ant...

Tildelt: kr 4,9 mill.

Prosjektperiode: 2006-2013

Sted: Troms - Romsa - Tromssa

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