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FRIBIO-Biologi og biomedisin

Plant Innate Immunity: Genetically engineered Brassica napus MINELESS plants and its effect on insect and sulphur stresses

The ability to discriminate between self and non-self is a key feature of all living organisms, and forms the basis for the activation of innate defence mechanisms against attempted microbial infection. Interestingly, innate immunity in plants and animals shows striking parallels, suggesting tha...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2008-2011

Sted: Trøndelag - Trööndelage

YFF-Yngre, fremragende forskere

The Function of Cyclin Dependent Kinases in the DNA Damage Response and Maintenance of Genome Stability

Project Summary Genome instability is one of the hallmarks of cancer. However, the mechanisms that protect the genome against spontaneous gross chromosomal rearrangements (GCRs) are not well understood. In recent years several pathways have been identifi ed that protect the genome against sponta...

Tildelt: kr 9,5 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Salmon and contaminants: impacts on insulin sensitivity and metabolic diseases

Although marine food has long been known to have health properties, its roles and impacts on insulin sensitivity and metabolic diseases (e.g. type 2 diabetes, obesity, hypertension, coronary heart diseases etc.) remain still unclear and worldwide debated. Beside its potential health effects, rec...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2011

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Bioinformatics platform for the pharmacogenomic analysis of sequence variation in complex diseases

Traditional studies of complex disease and drug response have utilized a one gene one drug strategy. However because of highthroughput technology , the future trend of personalized medicine lies in understanding and modulating the complex responses involv ing many genes, their sequence variation ...

Tildelt: kr 3,5 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Saxitoxin biosynthesis and genomics in organisms from two kingdoms - horizontal gene transfer or parallel evolution?

Paralytic shellfish poisoning is a potentially fatal affliction that results from the consumption of seafood or drinking water, which is infested with the neurotoxic alkaloid saxitoxin and its analogues (PSTs). Although PSTs are produced by a complex and unique biosynthetic pathway, distantly rel...

Tildelt: kr 3,9 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

IS-JSPS-JSPSmobilitet fra Japan

Takemasa, Makoto, JSPS-FY2008, long-term - Single molecular studies on polysaccharide complexes

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Tildelt: kr 0,33 mill.

Prosjektperiode: 2008-2009

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Down-regulation of gene expression in Gram-positive bacteria using RNase P

"Shoot the messenger"-strategies is a new innovative tool in functional genomic research of both bacteria and mammalian cells. This approach also holds promise for the development of a new class of therapeutics using RNA-molecules to silence unwanted gene expression in vivo. We will explore and ...

Tildelt: kr 1,9 mill.

Prosjektperiode: 2008-2011

Sted: Troms - Romsa - Tromssa

IS-STP-Statsstipendprogram, utlendinger

Panzacchi, Manuela Italia stp 07/08

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Tildelt: kr 79 000

Prosjektperiode: 2008-2008

Sted: Trøndelag - Trööndelage

IS-BILAT-Mobilitet Norge-USA /Canada

Reversible protein adsorption to membranes and nanoparticles

The delivery of protein-drugs using nanoparticles is an attractive therapeutic concept. The delivery would be greatly improved if the protein was firmly attached to the nanoparticle outside the target cell, and released when the nanoparticles enter the ce ll. Such a mechanism would rely on differ...

Tildelt: kr 0,19 mill.

Prosjektperiode: 2008-2008

Sted: Vestland

YFF-Yngre, fremragende forskere

Genetic dissection of the reproductive ground-plan hypothesis of social evolution

It is debated if social behavior is controlled at the molecular level by evolutionary novelties or by ancestral regulatory pathways. Our proposal aims to resolve this controversy by testing the reproductive ground-plan hypothesis of social evolution at th e genome level. This universal hypothesis...

Tildelt: kr 10,4 mill.

Prosjektperiode: 2008-2013

Sted: Akershus

IS-BILAT-Mobilitet Norge-USA /Canada

Studies of B cell lymphomas at the single cell level

In the research group of Prof. Erlend Smeland, where I have been working for several years, we are working with normal and malignant B cells to identify genes or aberrant signaling pathways that are of importance for the pathogenesis of lymphoma. Prof. Ro nald Levy at Stanford University School o...

Tildelt: kr 0,28 mill.

Prosjektperiode: 2008-2008

Sted: Ukjent Fylke

IS-BILAT-Mobilitet Norge-USA /Canada

Proteomic based biomarker discovery in patients with degenerative neurological disorders, infectious disease, and ovarian cancer

During his one year stay at the Broad Institute in 2008, Dr Berven will be working in the field of biomarker discovery. He will continue with activities connected to his main project, which is the discovery of disease specific polypeptide biomarkers in th e cerebrospinal fluid from multiple scler...

Tildelt: kr 0,30 mill.

Prosjektperiode: 2008-2008

Sted: Vestland

EU7RP-EUs 7. rammeprogram

EU-R&D Life Science Support Office (188148)

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Tildelt: kr 1,7 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Development of assays for diagnostics of viral diseases in farmed salmon: New tools for disease control based on host-pathogen interaction

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Tildelt: kr 1,7 mill.

Prosjektperiode: 2008-2011

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Protein-protein interactions at atomic levels

Our DNA is every day subjected to external and internal damaging agents and understanding the mechanisms of DNA repair at a molecular level is increasingly important in order to address future challenges for the human health. This project aims to reveal n ew information about molecular mechanisms...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2008-2014

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Salmon louse genome sequencing and functional studies on host parasite interactions

Copepods comprise the largest animal marine biomass but they have been poorly studied by molecular tools and no genome has so far been sequenced. Copepods are common as parasites on fishes and the salmon louse (Lepeophtheirus salmonis) is the most importa nt species in terms of economical signifi...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2008-2011

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Towards a systems level understanding of responses to endogenous DNA damage in Caenorhabditis elegans

The impact of genomic instability on human health underscores the importance of understanding the mechanisms that coordinate responses to DNA damage in order to preserve genomic stability. There is a disparity between our knowledge of the cellular respons es to endogenous DNA damage and the impac...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Host-virus interactions in Atlantic salmon

Infectious pancreatic necrosis virus (IPNV) and infectious salmon anemia virus (ISAV) are viruses causing threatening diseases in Norwegian aquaculture. Certainly, one of the most challenging problems in designing control strategies against these viruses is to define the specific factors, both in...

Tildelt: kr 12,0 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Postgenome glycomics: The structures, interactions, and functions of complex sugars attached to proteins and lipids

Glycome is a term meant to cover the whole set of glycans produced in a single organism (or tissue) in analogy to genome and proteome. This concept follows as a consequence of the development in the post-genome era, since glycans play critical roles in di verse biological phenomena. It seems evid...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

IS-AUR-Samarb.progr. Norge Frankrike

Baussant, Thierry Aurora 2008- Fransk-norsk forskerutveksling

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Tildelt: kr 21 275

Prosjektperiode: 2008-2008

Sted: Rogaland

IS-DAAD-Forskerutveksl. Norge-Tyskland

Hanssen, Anne-Merethe DAADppp 2008 Tysk-norsk forskerutveksling

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Tildelt: kr 50 000

Prosjektperiode: 2008-2009

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Bacterial flagellin: a novel adjuvant for vaccine strategies

The focus will be on development of strongly protective vaccines aimed primarily to fish, but the knowledge generated will be highly relevant within vaccine development to mammalian species - as fish possess very similar immune defence mechanisms compared to mammalian species. This will be achie...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2011

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Dissection of Epigenetic Mechanisms and Transcriptional Networks in Seed Development

Seed development is the product of double fertilization of the egg cell and the central cell by two sperm cells from the pollen and requires a coordinated interplay of the transcriptional programmes in the embryo, the endosperm and the maternal seed coat. Parent of origin dependent expression pl...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Epigenetic gene regulation: The 'conspiracy' between chromatin modification and transcription factors.

An important aspect of gene regulation involves the interconversion between transcriptionally permissive euchromatin and repressive heterochromatin, which in part is regulated by post-translational modifications of the nucleosomal histone tails. The patte rns of histone modification (the histone ...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

From comparative genomics to systems biology - unravelling novel principle virulence mechanisms in pathogenic spore-forming bacteria

In the past decade, our research group has been involved in the characterization of virulence mechanisms in Bacillus cereus group bacteria. Here we propose to study two processes connected to development of resistance to antimicrobial compounds - the func tion and cellular response of multidrug r...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional genomics in ascidians through insertional mutagenesis and homologous recombination

Ascidians, or sea squirts, are marine invertebrate chordates. Their critical evolutionary position as basal chordates and the simplicity of their embryogenesis have attracted great attention from developmental and evolutionary biologists. Recently, ascid ians have become one of the most promisin...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Functional and structural characterization of the membrane-integrated plastid phosphate translocators

Atomic structures of proteins provided a wealth of information about the functioning of proteins at the molecular level, e.g. the catalytic mechanisms of enzymes, pointing to the enormous impact of X-ray crystallography on modern biology. Because of techn ical hurdles almost all of the more than ...

Tildelt: kr 5,2 mill.

Prosjektperiode: 2007-2012

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Structure based rules for protein kinase inhibitor selectivity

Protein kinase inhibitors are now emerging as a major class of new targeted drugs. Many diseases, especially cancers, are associated with disregulation of signalling pathways, and modulation of protein kinase activity is now a clearly validated approach f or therapy. Because there are over 500 pr...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2013

Sted: Troms - Romsa - Tromssa

YFF-Yngre, fremragende forskere

Transcriptome regulation in development, disease and cancer

The loci of developmental transcriptional regulators are spanned by arrays of conserved noncoding elements (CNEs), many of which exhibit high similarity across all vertebrates. We are on the verge of discovering the fundamental involvement of these elemen ts and the genomic regions they reside in...

Tildelt: kr 8,8 mill.

Prosjektperiode: 2007-2015

Sted: Vestland

IS-NAD-Samarbeid med NORAD-land

Satyanarayana, Tulasi. Indisk spes 2007

...

Tildelt: kr 11 522

Prosjektperiode: 2007-2007

Sted: Vestland

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