0 antall prosjekter

Dato fra ny til gammel

FRIBIO-Biologi og biomedisin

The role of excitatory amino acid in Parkinson's disease

Parkinson's disease is characterised by death of dopamine containing neurons in the substantia nigra. Long term levo-dopa treatment has severe side effects and is potentially toxic for neurons. The need for alternative treatments in Parkinson's disease is urgent. To accomplish this, further rese...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

National resources for genomics, functional genomics and health research in Atlantic salmon and Atlantic cod. WP 3 (tidl del av177030)

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Tildelt: kr 2,4 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Protein aggregation and degradation in aging and disease: Role of polyubiquitination and autophagy

Hundreds of proteins encoded by the human genome have the propensity to form cytoplasmic aggregates under certain conditions. Although the mechanisms of intracellular protein aggregation are poorly understood, it is well known that deposits of aggregatete d proteins are highly associated with agi...

Tildelt: kr 8,6 mill.

Prosjektperiode: 2007-2011

Sted: Ukjent Fylke

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The Norwegian Multiple Sclerosis Registry and Biobank

Multiple sclerosis (MS) is an immune-mediated, inflammatory disease of the central nervous system (CNS) in genetically susceptible individuals. It is a disabling disease of young adults, with no curable treatment available. There is growing knowledge of s everal aspects of the disease, but the et...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

BIA-Brukerstyrt innovasjonsarena

DualPET-MR

The main objective for this project is to develop dual-modality PET-MR for molecular biology and medicine which will allow for the combined and simultaneous use of positron emission tomography (PET) and magnetic resonance (MR). In such a combined machine the PET provides information from molecula...

Tildelt: kr 5,1 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Proposal for a National consortium in Fish Genomics - FishGen

The present proposal describes the establishment of a National Consortium in fish genomics (FishGen). The main partners in the FishGen are; Institute of Marine Research (IMR), University of Bergen (UoB), National institute of nutrition and seafood researc h (NIFES), University of Tromsø (UiTø), N...

Tildelt: kr 14,0 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

NucPro: Epigenetics of nuclear programs - from genome-wide landscapes to individual factor mechanisms

This Proposal outlines research plans for global epigenetic and transcription factor studies at an already established Functional Genomics (FUGE) Consortium for studies of nuclear programs at the University of Oslo (UiO). The consortium is a joint effort from four independent research groups to e...

Tildelt: kr 11,0 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

EGF-induced Formation of Clathrin Coated Pits

Growth factor receptors control cellular growth and differentiation by transmitting signals from outside the cell to the cell interior, particularly the nucleus. Signal transmission can be modulated in several ways. To control signalling, down-regulation of receptors from the cell surface is impo...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Gene-environment interaction analyses and oral clefts in Norway

Norway has several large epidemiological studies with genetic bio-banks that may be used in etiologic research. Examples are the CONOR-cohort and the MoBa-cohort of children with mothers and fathers. Optimal analysis of such studies requires integration o f both genetic and environmental effects....

Tildelt: kr 2,8 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FRIMED-Klinisk medisin og folkehelse

THE HORDALAND WOMEN'S COHORT STUDY. A planned 15-year (1997-2012) follow up incidence study of urinary incontinence, and associated factors

Urinary incontinence (UI) is a common condition with a prevalence of about 25% of adult women, that affects the physical, psychosocial, and economic well-being. Longitudinal studies of incidence, remission and natural history are scarce. The Hordaland wo men's cohort study is an ongoing 15-year ...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FRIMED-Klinisk medisin og folkehelse

Exposure expression profiles in a prospective cancer study - The Norwegian Women and Cancer postgenome cohort

From 1991 women in Norway has been recruited to participate in NOWAC by postal questionnaires. They are drawn at random from the population through the central person register. Follow-up on cancer and death is based on linkage to national registers. Altog ether 150 000 women aged 30-70 years at r...

Tildelt: kr 1,6 mill.

Prosjektperiode: 2007-2010

Sted: Troms - Romsa - Tromssa

FRINAT-Matematikk og naturvitenskap

Investigation of equiaxed dendritic alloy solidification by in-situ synchrotron X-radiography and phase-field modelling

Important aspects of alloy solidification is poorly understood due to lack of means to observe the microstructure formation processes in situ during solidification. A new method, developed by the applicant, for in-situ acquisition of high resolution sync hrotron X-radiograms will be used to obta...

Tildelt: kr 6,9 mill.

Prosjektperiode: 2007-2010

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Does ovarian fluid favour MHC-dissimilar sperm?

When males provide nothing but genes, female choice of mates is expected to favour individuals that can best increase offspring survival. This selection process may not only occur at an individual level, but also on the gamete level. Recent studies have i ndicated that the ova may select sperm on...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2007-2010

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The role of T cell specific adapter protein in T cell activation and autoimmunity

Genetic variation in genes controlling T cell activation may be responsible for individual differences in fine-tuning of the immune response. Such variability may account for part of the genetic susceptibility to develop autoimmune diseases. Having a majo r interest in elucidating the aetiology o...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Life history patterns in large carnivores and their application for management and conservation.

Life-history is an organism's pattern of growth, reproduction and mortality, formed by long-term evolutionary processes and by immediate responses to the environment. This project has 3 main objectives: 1) evaluate the patterns of lifetime reproductive su ccess of male and female brown bears; 2) ...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2007-2011

Sted: Akershus

FRIMED-Klinisk medisin og folkehelse

Combined structural, microvascular and functional mapping of brain tumors for improved diagnosis and treatment planning

During recent years, the department of radiology at Rikshospitalet-Radiumhospitalet (RR) Medical Center has had a strong focus on functional MRI (Magnetic Resonance Imaging) research; including perfusion/ diffusion MRI and spectroscopy, with the aim of br inging novel MR techniques into early cli...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Characterization of Novel Insulin Regulated Pathways in Fat Synthesis in Liver and Adipose Tissue

Diets rich in lipids and carbohydrates together with a lack of physical exercise predispose individuals to multifunctional diseases such as atherosclerosis, hyperlipidemia, obesity, insulin resistance and diabetes type 2. Fat metabolism and glucose homeos tasis are inherently related, and insulin...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

The ecological and evolutionary significance of seed banks in Arabidopsis thaliana

Many studies of the genetic structuring of annual, selfing Arabidopsis thaliana populations on various geographical scales have been performed in recent years. Some studies conclude that local populations may contain relatively high amounts of genetic var iability both in phenotypic traits and pu...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2012

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Fe-S Cluster Biogenesis in Plastids and Mitochondria in Plants

Iron-sulfur (Fe-S) clusters are essential, inorganic cofactors of Fe-S proteins involved in numerous vital developmental processes. Although simple in structure Fe-S clusters are not formed spontaneously but require an intricate interplay of a number of p roteins and in plants Fe-S cluster biogen...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2010

Sted: Rogaland

FRIBIO-Biologi og biomedisin

Dynamics underlying astrocyte behaviour

For a long time astrocytes, the most abundant glial cell species, have been considered passive bystanders of neural activity. The picture that is now emerging is that astrocytes are critically involved in regulating brain function. Despite extensive exper imental efforts, a thorough understanding...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2009

Sted: Akershus

GLOBHELS-Global helse

Novel vaccine candidates and delivery systems for HIV and influenza

Aim: We wish to generate novel vaccines for important infectious diseases such as HIV (FRIBIOMOL)and influenza (GLOBVAC). Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However, for some important diseases such as HIV, there are no available vacc...

Tildelt: kr 2,0 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

A new Computed Tomography (CT) detector with color/dual-energy features and substantially reduced patient X-ray dose

Computed Tomography (CT) is one of the most important medical diagnosis tools of today. World-wide there is a waste number of installations, a strong increase in sales, and it represents consequently a big industry for the manufacturers. The X-ray detecto r in the CT is the main part of the machi...

Tildelt: kr 6,3 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

RENERGI-Fremtidens rene energisystemer

Energieffektivt og miljøvennlig CO2-varmepumpesystem for næringsbygg

Målet med prosjektet er å utvikle, bygge og demonstrere et energieffektivt og miljøvennlig varmepumpesystem med karbondioksid (CO2) som arbeidsmedium for oppvarming og kjøling av næringsbygg. Gjennom dette skal det legges et kunnskapsmessig grunnlag for n orsk produksjon av denne type systemer. D...

Tildelt: kr 0,62 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Improved methods for detection and strain identification of Tobacco rattle virus in Norway

Potetproduksjonen I Norge har I flere år vært skadelidende på grunn av rustflekksjuke - brune ringer og flekker - i potetknollene. Disse symptomene gjør potetene uegnet både til matpotet, pommes frites og potetgullproduksjon. Rustflekksjuke er hovedsakeli g forårsaket av to virus: potetmopptoppvi...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2007-2011

Sted: Innlandet

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Avl for bedre helse hos gris

Organisering og oppslutning i norsk svineavl er unikt internasjonalt. Tilslutningen til avlsarbeidet i næringa, faglig dyktighet i Norsvin samt aksept og støtte fra myndighetene har bidratt til at norsk avlsmatriale i dag er verdensledende på flere område r. Dette har resultert i at en internasjo...

Tildelt: kr 1,6 mill.

Prosjektperiode: 2007-2011

Sted: Innlandet

BIONÆR-Bionæringsprogram

NKJ 128 - Phenotypic and molecular characterisation of genetic resources of Nordic timothy (Phleum pratanese L.)

Timothy is the most important forage grass species in the northern part of the Nordic countries. However, serious winter damages, which significantly lower persistency and yields, occur regularly. The Nordic plant breeders have so far been quite successfu l in developing new, high-yielding variet...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2007-2012

Sted: Akershus

PROSDIV-Diverse

Towards self-sustainable European regional cattle breeds (EURECA)

Prosjektet omhandler bevaring og bruk av lokale/regionale kuraser: " status og organisering av eksisterende bevaringsprogrammer for disse i Europa " kartlegging av metodikk og software for forvaltning av genressurser " utvikling av perspektiver og retning slinjer for å utvikle raser og vellykkede...

Tildelt: kr 0,45 mill.

Prosjektperiode: 2007-2010

Sted: Akershus

BIA-Brukerstyrt innovasjonsarena

Fotokjemisk internalisering for cellegiftterapi av kreft

PCI Biotech AS utvikler en patentert teknologi for levering av legemidler, kalt fotokjemisk internalisering (forkortet PCI). Sentralt i denne teknologien står en patentert kjemisk forbindelse, kalt TPCS2a, som PCI Biotech utvikler for utprøving i pasiente r i innledende kliniske studier i kombina...

Tildelt: kr 8,5 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

Innovation on Signalling Disruptors - Development of drugs eliminating cAMP action in infectious disease (HIV/AIDS) and cancer

Compartmentalised cAMP-dependent signalling is involved in development of a number of diseases including HIV/AIDS, certain types of cancer, and other types of immunodeficiencies which affect several million citizens both in industrialised and developing c ountries each year. No organised approach...

Tildelt: kr 5,9 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

Produksjon av solbeskyttende karotenoider fra bakterier.

Produksjon av solbeskyttende karotenoider fra bakterier. De fleste solkremer beskytter dårlig mot stråling ved 360-500 nm (langbølget UVA og synlig blått lys), selv om det i de senere år er blitt fokusert også på disse bølgelengdene i forbindelse med mela nom hudkreft, fotoaldring og andre solind...

Tildelt: kr 6,8 mill.

Prosjektperiode: 2007-2010

Sted: Akershus

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