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Dato fra ny til gammel

FUGE-Funksjonell genomforskn.i Norg

Søknad om regionale midler til FUGE-N for perioden 2007-2011

Det regionale fagrådet for FUGE-N har hatt et budsjett på ca. 6,8 mill kroner i perioden 2002-2006 for å støtte regionale tiltak som bl.a. et kompetanseprosjekt, støtte til reiser for å øke kompetanse, lokale arbeidssamlinger og professor II-stillinger. E tableringen av FUGE-N har styrket og heve...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2007-2012

Sted: Troms - Romsa - Tromssa

GLOBHELS-Global helse

Immunity towards mycobacteria - identification of avirulent vaccine strains and therapeutic targets

Tuberculosis (TB) kills nearly 2 million people each year, and, together with HIV, Mycobacterium tuberculosis top the WHO list of deaths caused by infectious agents. In HIV infected individuals, Mycobacterium avium complex (MAC) is a major cause of second ary lethal infections. The only vaccine c...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2007-2014

Sted: Trøndelag - Trööndelage

S-AFRIKA-Program for forskningsamarbeid med Sør- Afrika

A Translational Effort to Develop Novel Magnetic Resonance Imaging Protocols and Sequences for Studying Myocardial Lethal Reperfusion Injury

Cardiovascular disease remains a leading cause of death worldwide. Impaired coronary circulation in the heart following a myocardial ischemic episode will lead to compromised hemodynamic function and ultimately cell death. Coronary reperfusion is the only means of limiting infarct size, provided...

Tildelt: kr 0,79 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Functional genomics and diabetes in Norway - Clinical, molecular, cellular and epidemiological analysis of monogenic diabetes

Diabetes is a common and severe disease. Maturity-onset diabetes of the young (MODY) is an inherited type of diabetes with decreased insulin secretion. Based on our national MODY Registry, we have recently identified a novel syndrome of exocrine and endoc rine pancreatic dysfunction caused by mut...

Tildelt: kr 8,5 mill.

Prosjektperiode: 2007-2012

Sted: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

FUGE II - Region West Application

This application is a response to the call for regional funding within the FUGE II program. Five professor II positions are requested to bring specific areas of expertise in support of systems biology, organelle biology, proteomics, microarray technology and marine functional genomic research. ...

Tildelt: kr 4,6 mill.

Prosjektperiode: 2007-2013

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Global metabolic switching in Streptomyces coelicolor

Systems Biology aims at understanding and predicting the properties of a biological system under targeted perturbations (e.g. genetic changes or changes in the external environment) with the use of integrated data analyses and mathematical modelling. It r equires a multidisciplinary approach incl...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2007-2010

Sted: Trøndelag - Trööndelage

SFF-Sentre for fremragende forskn

Center for Biomedical Computing, CBC

CBC har som formål å bruke matematikk, fysikk og datamaskiner for å oppnå en dypere naturvitenskapelig forståelse av problemstillinger innen medisin. Forskningen i senteret kan deles i to hovedkategorier. Den første er utvikling av beregningsmetoder og programvare for simulering av fysiske proses...

Tildelt: kr 77,0 mill.

Prosjektperiode: 2007-2017

Sted: Oslo

NANOMAT-Nanoteknologi og nye materialer

Multifunctional Particulate Systems for Nanomedicine

The following NANOMAT project represents the Norwegian part of the MATERA project called NANOMEDPART. The aim of the MATERA project is to develop effective methods for the preparation of nanosized particles and nanosized capsules built of metallic, polyme ric, inorganic and composite materials ap...

Tildelt: kr 5,7 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

SFI-Sentre for forskningsdrevet innovasjon

CAST - Cancer Stem Cell Innovation Center

SUMMARY SFI-CAST has been established by the Research Council of Norway with the aim of using knowledge about stem cell biology to improve our understanding of cancer, and to develop new therapeutic tools. SFI-CAST was hosted by the Oslo University Hospital (OUS) with the University of Osl...

Tildelt: kr 80,0 mill.

Prosjektperiode: 2007-2015

Sted: Oslo

SFI-Sentre for forskningsdrevet innovasjon

MabCent - Centre on Marine Bioactives and Drug Discovery

MabCents bioprospekteringsaktivitet i denne rapportperioden (01.12.13-01.12.14) har vært en fortsettelse av den omfattende aktiviteten som har foregått siden 2007 For å begynne med de biologiske ressursene, så gikk Marbank/MabCents hovedtokt (3 uker i mai) i år på øst og vestsiden av Svalbard ...

Tildelt: kr 76,0 mill.

Prosjektperiode: 2007-2015

Sted: Troms - Romsa - Tromssa

MILPAAHEL-Miljøpåvirkning og helse

Health Effects of Dietary DNA from Novel foods

The major fraction of DNA present in the food (dietary DNA) is degraded in the gastrointestinal tract. However, it is a recent and novel finding that a substantial fraction of intact dietary DNA, several hundred base pairs long, is taken up from the gastr ointestinal tract and distributed to bloo...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

A study of aging in the honey bee brain

The honey bee is a key neurobiological model for understanding learning and memory formation. As a highly social invertebrate, moreover, the bee provides unique opportunities for cutting-edge research on aging and frailty because it opens up the interface between the individual and the social en...

Tildelt: kr 7,0 mill.

Prosjektperiode: 2007-2010

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

Transcriptional and Metabolic Studies in Enterococcus faecalis

The study will be initiated by a thorough analysis of the metabolic pathways given by the genome sequence of Enterococcus faecalis V583. The project will investigat the metabolic characteristic of central carbon metabolism of E. faecalis with emhasis on s ugar utilisation. An important part of th...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2007-2010

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

Systems Biology of a genetically engineered Pseudomonas fluorescens with inducible exo-polysaccharide production: analysis of the dynamics a

The biosynthesis of the industrially important exopolysaccharide alginate will be used as a model system for global analysis of the functioning of metabolic networks in genetically engineered strains of the unicellular bacterium Pseudomonas fluorescens. T he level of synthesis of the polymer can ...

Tildelt: kr 9,3 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

NANOMAT-Nanoteknologi og nye materialer

Conformation and Physical Properties of Single Wall Carbon Nanotube-Biomolecule Hybrids

Nano-sized materials have unique physical properties due to their small dimensions and are presently of major strategic concern for most industrialised countries. One such material that has attracted major attention during the last one-and-a half decade a re carbon nanotubes (SWNTs), which exhibi...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Astrocytes - guardians of neuroprotection

Astrocytes are the most abundant cell type in the human cerebral cortex but the focus on these cell types have been far neglected. In the later years it has become apparent that they play important roles in the homeostasis of the brain and evidence now al so suggests that they are essential compo...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

cAMP signalling -novel downstream targets of PKA and Epac identified by phospho-proteomics.

I. Implement novel method for quantitative COFRADIC non-gel global phospho-proteomics through stay of candidate in the laboratory of prof. J. Vandenkerckhove at Univ. of Gent II. The phospho-proteome will be compared in cells in response to activation of PKA (by N6-MB-cAMP) or Epac (by 8-pCPT-2´-...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FRIBIO-Biologi og biomedisin

EGF-induced Formation of Clathrin Coated Pits

Growth factor receptors control cellular growth and differentiation by transmitting signals from outside the cell to the cell interior, particularly the nucleus. Signal transmission can be modulated in several ways. To control signalling, down-regulation of receptors from the cell surface is impo...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Dynamics of synaptic transmission in the rod pathway of the retina

A considerable challenge in neuroscientific research is to explain processes at the systems level in terms of mechanisms at cellular and molecular levels. The retina serves as an ideal model system amenable to experimental approaches that directly aim to bridge this gap. With respect to the senso...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

FRIBIO-Biologi og biomedisin

The role of normal neighbouring keratinocytes and fibroblasts on clonal expansion of oral cancer (stem) cells

Recent studies, including ours, have shown that the invasive behaviour of cancer cells is not solely due to mechanisms intrinsic to the individual tumour cell. Genetic changes of individual cells in a specific tissue are not sufficient for invasive cancer to develop. Rather, there is a vivid cro...

Tildelt: kr 1,1 mill.

Prosjektperiode: 2007-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

Electrical signaling in thin dendrites and axons in the cortex

A major challenge in neuroscience is to understand the mechanisms of neuronal computation, much of which is carried out by electrical signals generated by ion channels in the cell membrane. Within the last decade, advances in patch-clamp and imaging techn iques have extended our knowledge of such...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

GLOBHELS-Global helse

Novel vaccine candidates and delivery systems for HIV and influenza

Aim: We wish to generate novel vaccines for important infectious diseases such as HIV (FRIBIOMOL)and influenza (GLOBVAC). Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However, for some important diseases such as HIV, there are no available vacc...

Tildelt: kr 2,0 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Elucidation of downstream signaling events of cAMP using new tools distinguishing the roles of EPAC and PKA

The present project will receive Epac and PKA modulating cAMP analogs. I. We will test selected new analogs in a newly developed and unique assay for binding to PKA holoenzyme II. The best activators (current or novel) will be used, separately and jointl y, to define effect of Epac and PKA activ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

BIA-Brukerstyrt innovasjonsarena

Innovation on Signalling Disruptors - Development of drugs eliminating cAMP action in infectious disease (HIV/AIDS) and cancer

Compartmentalised cAMP-dependent signalling is involved in development of a number of diseases including HIV/AIDS, certain types of cancer, and other types of immunodeficiencies which affect several million citizens both in industrialised and developing c ountries each year. No organised approach...

Tildelt: kr 5,9 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

New therapeutic principles and biological mechanisms related to brain tumour cell invasion and angiogenesis

Primary gliomas represent one of the greatest challenges in neuro-oncology. Recent studies have identified so-called ?cancer stem cells? in several cancers. These cells have the capacity to proliferate and establish tumors in laboratory animals after inje ction of only a small number of cells. Mo...

Tildelt: kr 1,5 mill.

Prosjektperiode: 2007-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

The role of excitatory amino acid in Parkinson's disease

Parkinson's disease is characterised by death of dopamine containing neurons in the substantia nigra. Long term levo-dopa treatment has severe side effects and is potentially toxic for neurons. The need for alternative treatments in Parkinson's disease is urgent. To accomplish this, further rese...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

Novel serotonin receptor ligands for medical use

It is well known that serotonin receptor ligands can be useful drugs for treatment of diseases outside the central nervous system (CNS). The main target organs for non-CNS indications are the gastrointestinal system, bladder and cardiovascular system. Sev eral serotonin receptor ligands are in de...

Tildelt: kr 4,9 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

TU-Tungt utstyr

Functional Neuroanatomy of the Cortico-Parahippocampal-Hippocampal Memory System.

Memory is a property of distributed networks in the mammalian cortex. While the permanent storage of episodic memories is likely to take place at distributed locations in the neocortex, fast acquisition of such memories depends critically on the (para)hip pocampal system. This dependence reflects...

Tildelt: kr 6,8 mill.

Prosjektperiode: 2007-2010

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Protein aggregation and degradation in aging and disease: Role of polyubiquitination and autophagy

Hundreds of proteins encoded by the human genome have the propensity to form cytoplasmic aggregates under certain conditions. Although the mechanisms of intracellular protein aggregation are poorly understood, it is well known that deposits of aggregatete d proteins are highly associated with agi...

Tildelt: kr 8,6 mill.

Prosjektperiode: 2007-2011

Sted: Ukjent Fylke

FRIMED-Klinisk medisin og folkehelse

Psychosocial effects and understanding of increased risk for Type 1 Diabetes

With the rapid development in biotechnology and increasing knowledge about the relation between diseases and genetic variability, we are faced with both new opportunities and new dilemmas. Onset of a disease is dependent on several factors as genetic pene trance, combinations of genotypes and env...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

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