164 prosjekter

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Hip fractures: Predictors, incidence and survival. NOREPOS: The Norwegian Epidemiological Osteoporosis Studies

Hip fractures in Norway 1999-2008: time trends in total incidence and second hip fracture rates: a NOREPOS study. Eur J Epidemiol. 2012 Oct;27(10):807-14. doi: 10.1007/s10654-012-9711-9. Epub 2012 Jun 30 Norge har en av verdens høyeste rapporterte forek omst av hoftebrudd. Flere vestlige land ra...

Tildelt: kr 9,2 mill.

Prosjektperiode: 2009-2015

Sted: Vestland

FOLKEHELSE-Folkehelse

Risk factors and pregnancy outcomes of hyperemesis gravidarum (HG)

Cirka 1300 før Kristus var egypterne de første som beskrev sammenhengen mellom kvalme, oppkast og graviditet. I dag regner man med at opp til 80 % av alle gravide opplever kvalme eller kaster opp i løpet av graviditeten. Den ekstreme og alvorlige svangerskapskvalmen (hyperemesis gravidarum, HG), ...

Tildelt: kr 3,6 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

FOLKEHELSE-Folkehelse

Early life, environmental and genetic determinants of weight-related disorders among teenagers in Finland, Norway, Sweden, UK, USA and India

The consortium aims to develop a series of studies of the genetic and environmental influences on health and behavior among adolescent children in Finland, Norway, and the UK (applying consortium members), in collaboration with other research groups worki ng with teenagers and young adults in Ind...

Tildelt: kr 7,7 mill.

Prosjektperiode: 2009-2013

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Causes of autism spectrum disorders. Epidemiologic studies based on MoBa, the ABC Study and the Autism Database.

Autismespekterforstyrrelser (ASF) har fått mye oppmerksomhet den senere tid som følge av observert økt forekomst i høyinntektsland, og spekulasjoner rundt en mulig årsakssammenheng med vaksiner eller andre eksponeringsfaktorer i miljøet. Kunnskapen om årsaker til ASF er imidlertid begrenset. Heru...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2009-2016

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Changes over time in cancer survival and mortality in an ageing Norwegian population and the significance of sociodemographic conditions

The substantial increase in the number of very old persons in Norway over the last decades has had a marked impact on the burden of cancer in our society. This project aims to generate knowledge on changes over time in cancer survival and mortality among the very old, here defined as persons 75 ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

RUSMIDDEL-Rusmiddelforskning

The impact of parental alcohol abuse on the mental health of the offspring: A prospective population based study

Research has showed that children of alcohol abusers struggle with an array of psychological and behavioral problems. Although research has established an increased risk of adverse outcomes for this group, individual and gender based differences indicate a complex relationship. NOU 2003:4 and Opp...

Tildelt: kr 5,1 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

PSYKISK-Psykisk helse

Network for Psychiatric Epidemiology. Causes and consequences of mental disorders

Network for Psychiatric Epidemiology (NEPE) is a Norwegian network for mental health epidemiology aiming to run and facilitate research projects on causes and consequences of mental disorders. The present project will take advantage of the research possi bilities nearly unique for Norway by empl...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2009-2014

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Congenital heart defects in Norway - A nation-wide study

Vi har benyttet nasjonale helse- og populasjonsregistre for å undersøke risikofaktorer for medfødte hjertefeil i Norge. Epidemiologiske studier av medfødte hjertefeil har tidligere ikke vært utført på ett nasjonal nivå grunnet manglende data. Slike studier er viktige fordi medfødte hjertefeil er ...

Tildelt: kr 5,2 mill.

Prosjektperiode: 2009-2017

Sted: Vestland

RUSMIDDEL-Rusmiddelforskning

The effect of parental alcohol and drug abuse on children's future psychiatric disorders: modes of influence

There is irrefutable evidence for the fact that children of alcohol and substance abusing parents (ASAP) suffer a long range of mental health problems. Identifying potential adverse effects of ASAP on children's development is important for variety of rea sons, including legitimating societal res...

Tildelt: kr 5,1 mill.

Prosjektperiode: 2008-2011

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Pelvic girdle pain in pregnancy: Endocrine risk factors, physical activity and prognosis.

Background: Pelvic girdle pain affects one in five pregnant women, gives rise to functional disabilities and is a major cause of sick leave in pregnancy. Hence, pelvic girdle pain should be regarded as a major women's health issue. Nevertheless, the aetio logy is poorly understood. Pregnancy repr...

Tildelt: kr 3,6 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

The role of infections, vitamin D exposure and lifestyle factors on the risk of multiple sclerosis

Multiple sclerosis (MS) is a disabling neurological disease with still unknown causes. In addition to a yet unspecified genetic component, there is compelling evidence for the existence of one or more exogenous factors. To study the importance of such exo genous factors a large-scale internationa...

Tildelt: kr 0,14 mill.

Prosjektperiode: 2008-2009

Sted: Vestland

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The Autism Database

The prevalence of autism spectrum disorders (ASD) has increased approximately 10-fold over the past 20 years, now affecting about 60 pr 10 000 children. ASDs are highly heritable neurodevelopmental disorders, with environmental factors possibly functioni ng as triggers in genetically susceptible...

Tildelt: kr 1,00 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Night work, circadian gene polymorphisms and breast cancer risk among female nurses. A nested case-control study

Less than half of all breast cancers can be explained by known risk factors. Results from recent epidemiological studies have been largely consistent in suggesting a positive association between night work and increased risk of breast cancer in women. Th ese findings suggest a role of circadian ...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Prediction of fetal growth restriction by maternal perception of fetal activity

Fetal growth restriction (FRG) is a major challenge in obstetric care, and a significant risk for severe disabilities and death. Risk is reduced by early detection, but prediction in antenatal care is poor. FGR is associated with decreased fetal movements (DFM). Pregnant women universally perfor...

Tildelt: kr 4,6 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Folate, Paternal Age and De Novo Genetic and Epigenetic Events.

De novo mutasjoner er endringer i arvematerialet (DNA) som oppstår i kjønnscellene eller tidlig i fosterutviklingen og som derfor er nye i den forstand at de ikke finnes hos foreldrene. Epigenetiske mekanismer er kjemiske endringer i arvematerialet som styrer hvorvidt et gen skrus av eller på, op...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2008-2015

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Type 1 Diabetes and the Hygiene Hypothesis (helminths and parasites, and symptomatic virus infections)

Type 1 Diabetes (T1D) is one of the most prevalent chronic diseases with childhood onset. The incidence of T1D has increased with 25% during the last three years, and threefold during the last generation. The disease has a multifactorial aetiology and app ears after a long period where the immune...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

RUSMIDDEL-Rusmiddelforskning

A biomarker-based tool to monitor community drug use and abuse in Norway: Monitoring of substances of abuse in wastewater effluents

An estimate of the Norwegian situation for addictive drugs is based mainly on the following input: - Death and disease associated with the use of drugs - Crime associated with drugs (e.g. number of seizures of different drugs, amount of confiscated drugs and blood samples from drivers suspected f...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

RUSMIDDEL-Rusmiddelforskning

Pathways and consequences of alcohol, cannabis and prescription drug involvement. A longitudinal 13-year follow up of a population sample.

This research project has three main research questions. (1) What is the importance of alcohol and drug use debut age for later development of drug problems? (2) What are the risk factors for later cannabis use and what are the consequences of this use? ( 3) What are the risk factors for later us...

Tildelt: kr 3,5 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

Maternal Corticotropin-releasing hormone levels during pregnancy and offspring levels of Adiponectin

Obesity and it's consequences are emerging as a prime threat to health in the western world. During the last 20 years the prevalence of obesity has increased in all age groups, including children. This has led the search for etiological clues. Several st udies have shown an association between l...

Tildelt: kr 33 000

Prosjektperiode: 2008-2008

Sted: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Preschool ADHD: Early characteristics, developmental trajectories, risk and protective factors in a prospective birth cohort

Background: ADHD is highly prevalent, characterized by age inappropriate levels of inattention, hyperactivity and impulsiveness. It represents a substantial threat to healthy social and academic development, and increased risk for psychiatric comorbidity. Knowledge about early characteristics, d...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2008-2015

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Diabetes and diabetes precursors: detection, classification, prediction, genetics, complications and prevention. The Tromsö Study.

The incidence and prevalence of diabetes mellitus are increasing in many populations, and diabetes is now one of the most prevalent chronic diseases worldwide. Diabetes carries a great disease burden in terms of morbidity, mortality and costs. Most cases are classified as Type 2 diabetes, which h...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2011

Sted: Troms og Finnmark - Romsa ja Finnmárku - Tromssa ja Finmarkku

RUSMIDDEL-Rusmiddelforskning

Pilot study: prevalence of alcohol and drugs at the workplace

Alcohol and drug abuse affects society in many ways, e.g., health, social relations, safety, and productivity at the workplace. Alcohol is more significant in this respect than drugs because the use of alcohol is common and accepted by society. Testing of oral fluid (saliva) may be used to dete...

Tildelt: kr 1,00 mill.

Prosjektperiode: 2008-2009

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Hearing loss and tinnitus: genetic and environmental effects

Depending on the criteria used 1/3 - 1/6 of the population experience hearing impairment. Tinnitus is defined as the sensation of sound without any outer sound stimulus present. Environmental risk factors such as noise exposure are frequently described fo r both the diseases. A genetic component ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2008-2015

Sted: Oslo

FOLKEHELSE-Folkehelse

Physical activity and chronic pain in HUNT 3 - A prospective cohort study

Regular physical activity promotes health. An inactive lifestyle may alter gene expression, influence negatively on several organ systems and thereby cause chronic disease and increase mortality. These conditions may be reversed by regular activity and in creased level of physical fitness. Physic...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Folate and fatty acids in early life and neurodevelopmental disorders: developmental language delay as an early marker

We intend to study the relationship between intake of folate and fatty acids during early life and the risk of neurodevelopmental disorders (ND) such as autism and attention deficit/ hyperactivity disorder (ADHD). Having language problems at the age of three is a strong predictor for neurodevel...

Tildelt: kr 5,2 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

FOLKEHELSE-Folkehelse

Past and current physical activity levels and the risk of fracture in a population based study with 25 years follow-up

Norway has the highest fracture incidence in the world, and data from Oslo indicate increasing incidence in both sexes to the end of 1990. Physical activity stimulate bone formation during growth and maintain bone strength and reduce bone loss in adulthoo d and old age. Physical activity througho...

Tildelt: kr 3,6 mill.

Prosjektperiode: 2007-2011

Sted: Troms og Finnmark - Romsa ja Finnmárku - Tromssa ja Finmarkku

FRIMED-Klinisk medisin og folkehelse

Statistical modelling for infectious disease

We want to build a viable research group in statistical and mathematical modelling of infectious disease. We wish to make important original contributions to statistical methodology for analysis on infectious disease data, for the further purpose of aidin g, monitoring and understanding the sprea...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

MILGENHEL-Miljø, gener og helse

Cardiovascular morbidity and mortality: Effects of noise or air pollution or both?

Since road traffic is a source of both air pollutants and noise, it is very important to disentangle the health effects of the two very different types of environmental exposures related to road traffic. There are indications that both noise and air pollu tion are associated with increased risk o...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Gene-environment interaction analyses and oral clefts in Norway

Norway has several large epidemiological studies with genetic bio-banks that may be used in etiologic research. Examples are the CONOR-cohort and the MoBa-cohort of children with mothers and fathers. Optimal analysis of such studies requires integration o f both genetic and environmental effects....

Tildelt: kr 2,8 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FRIMED-Klinisk medisin og folkehelse

Psychosocial effects and understanding of increased risk for Type 1 Diabetes

With the rapid development in biotechnology and increasing knowledge about the relation between diseases and genetic variability, we are faced with both new opportunities and new dilemmas. Onset of a disease is dependent on several factors as genetic pene trance, combinations of genotypes and env...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2007-2010

Sted: Oslo