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FRIBIO-Biologi og biomedisin

2010 meetings of SFRR and EEMS in Oslo

The Society for Free Radical Research (Europe) and the European Environmental Mutagen Society independently decided to hold their annual meetings in Oslo, and asked Andrew Collins (University of Oslo) and Gunnar Brunborg (Norwegian Institute of Public Hea lth) to organise the meetings back-to-bac...

Tildelt: kr 0,20 mill.

Prosjektperiode: 2010-2010

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Network functions of newly generated neurons and cellular mechanisms of place cell activity in adult hippocampus

In this proposed research program, we will combine state-of-art genetic and electrophysiological technologies to reveal mechanisms supporting adult hippocampus functions. The proposal is largely divided into two parts. 1) Network functions of newly gener ated neurons in adult dentate gyrus. New ...

Tildelt: kr 10,3 mill.

Prosjektperiode: 2010-2014

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Intrinsic limitation of the field metabolic rate in a free-ranging Arctic seabird: the role of oxidative stress

The rate of energy expenditure integrates nearly all aspects of the ecology of a species, and knowledge of the factors limiting energy expenditure is of paramount importance for a better understanding of the evolution of life-history traits in free-living species. One factor which may exert a po...

Tildelt: kr 3,9 mill.

Prosjektperiode: 2010-2013

Sted: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Human protein N-terminal acetyltransferases: A protein-modifying enzyme family essential for cell survival and peptide hormone regulation

Acetylation is a very common protein modification occurring both at lysine residues within proteins (N-epsilon-acetylation or lysine acetylation) and at N-termini of proteins (N-alpha-acetylation or N-terminal acetylation). Lysine acetylation has been stu died extensively and it provides importan...

Tildelt: kr 10,9 mill.

Prosjektperiode: 2010-2014

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Inflammasome activation by cholesterol crystals

Atherosclerotic lesions are focal thickenings of the innermost layer of the artery consisting of cells from the artery cell wall, connective tissue elements, liquid and crystalline lipids as well as blood-borne immune cells. Immune cells in atheroscleroti c lesions show signs of activation and pr...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2010-2014

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cellular Interactions with the Extracellular Matrix of Tumour Microenvironment

Interactions of cells (both tumour and stromal cells) with extracellular matrix (ECM) are an important part of the influence of the microenvironment on tumour progression. ECM interacts with cells via integrin receptors, as well as other receptors, and pr ovides signals for cell proliferation and...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2010-2013

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Evolvability of allometry

In spite of a long-term interest of biologists and especially evolutionary biologists in allometry, biological and genetic models underlying the changes in relative dimensions of parts of the body that are correlated with changes in the overall size are s urprisingly few, and the evolution of all...

Tildelt: kr 7,3 mill.

Prosjektperiode: 2010-2015

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

3rd International Conference on Compartmentalized cAMP Signaling (jointly with FEBS Workshop on Spatiotemporal Dynamics of Cell Signaling)

There is a need for European and international scientists in the area of cell signaling to get together and bring attention to new subjects such as spatiotemporal organization, compartmentalized cAMP and modeling of signaling. Furthermore, European scient ists should get together for networking t...

Tildelt: kr 0,15 mill.

Prosjektperiode: 2010-2011

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Was the DEK1 protein key to the development of differentiated multi cellular land plants?

DEK1 consists of a calpain cystein proteinase linked to a 21 transmembrane protein module. Dek1 is an essential gene for plant development that specify epidermal cell fate in all organs by a position dependant, cell autonomous mechanism. Its essential rol e in plant development is supported by th...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2010-2014

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Can Cysteine Metabolism Provide a Target to Treat Obesity?

Framdriftsrapport. Rapporteringsfrist: 20121001. Mottatt: 20130211. 197195 - Can Cysteine Metabolism Provide a Target to Treat Obesity? Side: 8 begrenset. Flere av de beskrevne prosjektene vil nå bli utvidet til også å inkludere aminosyre- og fettsy reprofilen, noe som vil markert heve kvaliteten...

Tildelt: kr 9,4 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Biogenesis of plant photoautotrophy

Fotosyntetiserende organismer som planter og alger stammer fra fotosyntetiserende bakterier. De begynte å høste lys energi for å gi energi til sine metabolske behov og bli autotrofe for mer enn tre milliarder år siden. Sentralt i prosessen for fotosyntese og autotrofi er klorofyll. Molekylet er s...

Tildelt: kr 10,3 mill.

Prosjektperiode: 2010-2015

Sted: Rogaland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cardiac stroke volume and its contribution to the circulation: Interaction of mechanical and nervous factors affecting the heart

Når du puster, påvirkes hjertet av både nervøse og mekaniske faktorer. Mitt prosjekt har som hovedfokus å se på samspillet mellom mekaniske og nervøse påvirkninger av hjertets slagvolum. I prosjektet har jeg utviklet og publisert en ny metode for å måle s lagvolum fra hjertets høyre og venstre si...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The pathogenic role of chemokines in atherogenesis and plaque destabilization

I korthet har prosjektet tatt utgangspunkt i kjemokiners betydning i utviklingen av aterosklerose. Kjemokiner er potente kjemoattraktanter av inflammatoriske celler inn til blant annet blodkarets vegg. Dette gjør at kjemokiner kan være spesielt viktig i utviklingen og destabilisering av aterosk...

Tildelt: kr 4,2 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Identifying molecular targets on cancer stem-like cells from human brain tumours

The overall objective of our laboratory is to determine the biological mechanisms underlying brain tumour development and identify novel therapeutic targets that will block or reduce tumour progression. Our research group has been able to isolate two diff erent phenotypes from human glioblastomas...

Tildelt: kr 7,2 mill.

Prosjektperiode: 2010-2013

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The anatomy of memory: circuitry and functions of the hippocampal-parahippocampal region.

The human hippocampal-parahippocampal region plays an important role in memory. The relationship between the circuitry contained in this brain region and its contribution to memory is a topic of intense research, yet to date there is no complete and mecha nistic understanding of how the circuitry...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2010-2014

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Conference on "Membrane Dynamics in Endocytosis"

This is a proposal for the eleventh in a series of highly successful biannual European meetings on Endocytosis. The meetings have been alternating between European countries, and the most recent ones were organized in Spain in September 2005 and in Switze rland in September 2007. It is custom tha...

Tildelt: kr 49 999

Prosjektperiode: 2009-2011

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanisms of mammalian DNA Repair

DNA repair prevents cancer and early aging and is essential for adaptive immunity. Our objective is to obtain detailed understanding of the mechanism of base excision repair (BER) and direct base damage repair by human AlkB homologs. In addition, we will now expand our research into possible epi...

Tildelt: kr 5,9 mill.

Prosjektperiode: 2009-2013

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Membrane trafficking of Toll-like receptors in inflammatory reactions

Intracellular membrane trafficking plays key roles in cell signalling and immune responses. Endocytosis and subsequent endolysosomal trafficking of immune receptors constitute a crucial mechanism for receptor signal attenuation and antigen presentation. F or innate immunity against gram-negative ...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2009-2012

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Dormancy cycling: from signals to developmental transitions

Trær og andre stauder må avbryte sin vekst før vinteren. Riktig planlegging er viktig, fordi trær må optimalisere balansen mellom vekst og vinter beskyttelse. Løvtrær i den nordlige klima måler fotoperiode for å arrestere vekst, etablere endogen hvile, og tilegne seg toleranse mot frysing. En va...

Tildelt: kr 8,4 mill.

Prosjektperiode: 2009-2015

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

TRAIT-BASED ECOSYSTEM MODELS: FROM INDIVIDUALS TO BIODIVERSITY IN AQUATIC COMMUNITIES

There is a pressing need to develop predictive aquatic ecosystem models to better understand and mitigate effects of global warming, eutrophication and fisheries. Contemporary models a limited number of bulk-biomass functional groups; typically two phytop lankton (flagellates and diatoms) and a f...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2009-2015

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

DNA glycosylases initiating removal of oxidative DNA base lesions in mammalian cells

Most mutagenic and carcinogenic agents induce covalent changes in the DNA structure and a large number of gene functions have evolved to effectuate repair or tolerance of such alterations without loss of viability or development of disease. DNA repair mec hanisms are probably the most important c...

Tildelt: kr 5,9 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Microbial genomes and community gene expression in High Arctic terrestrial ecosystems.

Arctic soil contains large amounts of stored organic carbon which constitute a source for release of climate gases. Degradation of organic carbon involves a consortium of microbial phyla representing a huge genetic and functional diversity. The project ai ms at exploring the genomic and functiona...

Tildelt: kr 4,2 mill.

Prosjektperiode: 2009-2013

Sted: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The social environment & the epigenome: a global epigenetic study in the first invertebrate model with complete capacity for DNA methylation

DNA metylering er et epigenetisk merke som tar del i X-kromosom deaktivering, innprinting, regulering av genutrykk, og alternativ RNA spleising hos pattedyr. Honningbier har et epigenetisk maskineri med det samme evolusjonære opphav og de samme funksjonelle delene som maskineriet hos oss menneske...

Tildelt: kr 6,5 mill.

Prosjektperiode: 2009-2015

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

HLA association of Celiac Disease: Why is only DQ2.5 but not the highly homologous DQ2.2 predisposing to disease

Celiac disease (CD) is a common disorder that is caused by the ingestion of gluten and displays a very clear association to genes that encode the allelic HLA variant DQ2.5 (DQA1*05, DQB1*02). The functional explanation for this strong HLA association is t hat DQ2.5 has a unique capability to bind...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Host microbe interactions: -Elucidating genetic traits that govern transition from a commensal to a pathogenic lifestyle of Enterococcus fae

E. faecalis is part of the normal gut microbiota of healthy humans. Remarkably, while certain strains are used as probiotics, at the same time E. faecalis is also a prominent cause of nosocomial infections. Currently it is not understood whether E. faecal is nosocomial infections are caused by hi...

Tildelt: kr 5,7 mill.

Prosjektperiode: 2009-2014

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Regulation and organization of chromosome replication and segregation in Escherichia coli.

In Escherichia coli, reinitiation at new origins is prevented by two different control systems. First, a process called sequestration makes newly formed origins unavailable to the initiation apparatus. The sequestration process involves membrane component s, SeqA protein and methylation at GATC s...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Characterization of plant associated AlkB-like demethylases

AlkB-proteinet hos bakterier er et enzym som reparerer, dvs fjerner, skadelige metylgrupper i cellens arvestoff. Metylerende stoffer finnes både inne i celler og i miljøet, og AlkB motvirker derfor de negative effektene av slike stoffer. Multicellulære organismer, f. eks. planter og mennesker, ha...

Tildelt: kr 6,8 mill.

Prosjektperiode: 2009-2015

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Female infidelity promotes male cooperation in collective predator defence or sharing of resources

Revealing the adaptive value of mate choice and female preference for ornamented males has been one of the great challenges to sexual selection. While female choice for direct benefits is considered important in species with biparental care, most theory h as focused on female choice for male gene...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2009-2013

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Gene transfer between Streptococcus pneumoniae and its commensal relatives in biofilms

It is well documented that the commensal species Streptococcus mitis and Streptococcus oralis constitute a reservoir of antibiotic-resistance determinants that are easily transferred to Streptococcus pneumoniae by natural genetic transformation. Naturally transformable bacteria take up naked exo...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2009-2013

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular dissection of a novel epigenetic memory mechanism in Norway spruce

Forests are ecologically and economically important. An understanding of climatic adaptation of trees is crucial, especially in a scenario of rapid climatic warming. We propose to study the molecular regulation of climatic adaptation in Norway spruce, whi ch includes a novel epigenetic memory mec...

Tildelt: kr 5,5 mill.

Prosjektperiode: 2009-2014

Sted: Akershus

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