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PSYKISK-Psykisk helse

EARLY BIPOLAR DISORDER: CLINICAL AND BIOLOGICAL CHARACTERISTICS IN FIRST EPISODE MANIA

Bipolar disorder (BPD) is a severe psychiatric disorder characterized by manic and depressive episodes with periods of normal mood in between. Recent lines of evidence suggest that BPD is a more severe illness that previously believed and it is regarded as one of the most important factors contr...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

PSYKISK-Psykisk helse

Anxiety disorders in children- association with neurodevelopmental delay/disorder and temperament/personality. A clinical case-control study

Anxiety disorders (AD's) in childhood are common and may cause great suffering.Childhood AD's may persist into adulthood and knowledge of important risk factors for development and maintenance of these disorders is essential.The development of AD's is due to a complex interaction between biologi...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

PSYKISK-Psykisk helse

Integrating psychotherapy research and research on psychotherapy training

A promising line of research to improve the general effectiveness and efficacy of psychotherapy and to reduce dropout is to focus on the investigation of alliance formation and repair of alliance ruptures. This study draws upon five essential components: (1) focus on interpersonal process; (2) th...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2007-2015

Sted: Oslo

PSYKISK-Psykisk helse

Major depression, cognitive function and cortisol

Our knowledge of the relationships between depression, cortisol levels and daily cortisol profiles, and cognitive impairment in a long-term perspective is scant. We aim to study these relationships over two years in patients with MDD diveded in to subgrou ps of patients with a first time episode,...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2006-2014

Sted: Vestland

PSYKISK-Psykisk helse

The effects of serotonin polymorphisms and gender on cognitive control and brain function in major depression and healthy subjects.

Major depressive disorders (MDD) present a significant mental health concern to individuals and to our society and there is strong evidence that women are diagnosed with MDD twice as much as men. Cognitive functioning is the main outcome variable of this project. However, there is a considerable ...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

PSYKISK-Psykisk helse

Chronic skin diseases, depression, self-esteem and body image among adolescents in Oslo

Negative self-evaluation is central in the maintenance of depression, and low self-esteem among depressed individuals is described with experienced feelings of inadequacy, inferiority, worthlessness and incompetence. Self-esteem related to body image is s alient among adolescents especially femal...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

RUSMIDDEL-Rusmiddelforskning

The Karolinska Project for Early Treatment of Women with Alcohol Addiction (EWA). Mortality and Morbidity 15-25 years after treatment

Summary: This is a unique, prospective longitudinal study of 420 women with alcohol addiction who were treated within a specialized woman only treatment program (EWA) that was started in 1981. Based on a randomised design, 100 of the eligible women were t reated at EWA, while another 100 were ref...

Tildelt: kr 3,8 mill.

Prosjektperiode: 2006-2011

Sted: Ukjent Fylke

RUSMIDDEL-Rusmiddelforskning

Alcohol problems and depression: A 15-year longitudinal, nationwide study of mental health among Norwegian doctors.

Background: Concurrent depressive disorder and abuse of alcohol is common in the general population, and longitudinal studies that clarify this interplay over time and identify risk factors are highly required. Health care workers and in particular doctor s show high levels of depressive symptoms...

Tildelt: kr 4,2 mill.

Prosjektperiode: 2006-2012

Sted: Oslo

PSYKISK-Psykisk helse

SUSCEPTIBILITY GENES FOR SCHIZOPHRENIA AND BIPOLAR DISORDER: TRANSLATING FUNCTIONAL GENOMICS TO CLINICAL PSYCHIATRY.

Schizophrenia (SCZ) and bipolar (BP) disorder are severe mental disorders, which are both ranked among the leading causes of the total burden of diseases worldwide. Despite decades of research devoted to psychotic illnesses, the understanding of underlyin g biological mechanisms is inadequate and...

Tildelt: kr 5,2 mill.

Prosjektperiode: 2006-2010

Sted: Vestland

PSYKISK-Psykisk helse

Family-based Treatment of Depressed Adolescents: An Empirical Study with Norwegian Adolescents in Specialty Mental Health Care

Depression disorder affects 9-11% of Norwegian and Scandinavian adolescents. The prevalence is higher (61%) for those in mental health care. Depression and affective disorders in adolescence have negative consequences for the individual, family and the so ciety at large. There is an emerging body...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2006-2009

Sted: Rogaland

PSYKISK-Psykisk helse

Supporting Patient Communication and Coping with Illness in Childhood Cancer

Children with cancer experience complex physical, psychosocial, and behavioural symptoms/problems due to the illness treatment, uncertain diagnosis, and medical procedures. To help children cope with their problems and prevent psychological distress, we d eveloped the support system, Peds-CHOICE,...

Tildelt: kr 3,7 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

PSYKISK-Psykisk helse

Effects of integrated and comprehensive treatment to persons with mental disorders and substance use disorders.

Patients with co-occurring substance abuse and mental disorders are characterized by high suicide and treatment drop-out rates, and long-lasting interpersonal, work, school, health and legal problems. And because mental disorders and substance misuse inte ract and co-excists, it is important to p...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2006-2009

Sted: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Pathways to Adolescent Depression in Immigrant Youth: Longitudinal Studies

The main goal is to investigate the role of specific psychosocial profiles underlying depressive disorders in adolescence, and ethnic group variation in the distribution of adolescents among the identified profiles. The subgoals are 1)Examine 3 hypothesi zed and other unanticipated psychosocial ...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2006-2013

Sted: Oslo

PSYKISK-Psykisk helse

Developmental pathways of mental health problems from childhood through adolescence

The aim of the present project is to examine developmental pathways of mental health problems among children included in the Bergen Child Study (BCS) (www.uib.no/bib). In the first step, all children attending 2. to 4. grade in the Bergen and Sund munici palities in Norway in 2002 (n=9652) were ...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Vestland

PSYKISK-Psykisk helse

Coping and protection - A longitudinal study of children and their mothers

The principal objective is to attain knowledge about pathways to good social competence or mental health problems among children and their mothers. The longitudinal perspective implies studying health outcomes among children associated with age typical de velopment, and maternal health outcomes a...

Tildelt: kr 2,1 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

PSYKISK-Psykisk helse

A Translational Basic Research Programme on ADHD

This proposed, integrated project is centred on understanding the neurobiology of Attention-Deficit/Hyperactivity Disorder (ADHD). Recent advances in modern neuroscience make it possible to make a focused attack on the topic. The proposal contains a multi disciplinary approach with different leve...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

PSYKISK-Psykisk helse

ADHD in Norway: Basic and translational studies

Attention deficit hyperactivity disorder (ADHD) is a common condition among school age children world-wide. In addition, most affected individuals will continue to show symptoms as adults. Still, it has long been considered a controversial diagnosis in th e general population, as well as in the p...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2005-2009

Sted: Vestland

PSYKISK-Psykisk helse

Suicide among children in Norway

Suicide among children below 16 years of age occurs infrequently, but in Norway this problem has been growing. Suicide ideations and threats from children are more often registered in clinical settings. There is a lack of knowledge concerning this issue i n the international community. There is a...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2005-2012

Sted: Oslo

PSYKISK-Psykisk helse

Characterization of early trauma/dysmorphogenesis and adult neurodysfunction in schizophrenia – relation to adult brain morphology

Schizophrenia is considered to be a neurodevelopmental disease. Genetic factors as well as early-life environmental influences are implicated in its etiology. The aim of the doctoral project is to characterize patients with schizophrenia spectrum disorder with regard to history of obstetric comp...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2005-2010

Sted: Oslo

PSYKISK-Psykisk helse

Communication, somatisation and alexithymia. The impact of alexithymia for the process of somatisation in context of clinical communication

Background: Chronic health complaints are prevalent in general practice and in psychiatry and are often labelled as medically unexplained symptoms (MUS). Sensitisation has been proposed as an underlying neurobiological substrate for MUS. We suggest that a deficit in affect regulation, operationa...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2005-2009

Sted: Oslo

PSYKISK-Psykisk helse

Prognose, incidens og prediksjon ved depresjon og suicidalitet hos tenåringer: En oppfølging av prosjektet - Ungdom og psykisk helse.

Bakgrunn. Epidemiologiska studier har visat att 0,4-8% av tonåringar har depressiv störning eller dystymi. Den kumulativa prevalensen for depressiv störning är 15-20%. Förekomsten ökar särskilt hos flickor under puberteten. Komorbiditeten är hög oc h vanligast är ängeststörning, missbruk a...

Tildelt: kr 0,70 mill.

Prosjektperiode: 2003-2010

Sted: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Longitudinal MRI Studies of Brain Morphology in Schizophrenia and Bipolar Disorder: Etiological Risk and Genetic Association.

Schizophrenia is often considered being a neurodevelopmental disease. The phenotype is heterogeneous with high heritability (80%) and unknown etiology and pathophysiology. Morphological brain abnormalities appear to be intrinsic features of the disease. I n previous scientific studies, abnormalit...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

PSYKISK-Psykisk helse

How to help when silence is not golden? A RCT study of children with selective mutism (SM) 3-9 years of age

Selective mutism (SM) describes inhibited, anxious and withdrawn children who are persistently mute in important social situations despite ability to talk. SM may cause great suffering and create problems, both socially and educationally, and problems per sist. SM is associated with social anxiet...

Tildelt: kr 4,4 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

PSYKISK-Psykisk helse

The BDNF hypothesis of depression: a new framework for understanding depression and the actions of antidepressant drugs

Despite decades of research, the biological basis of major depression remains to be fully elucidated. Although antidepressants, such as serotonin reuptake inhibitors, rapidly increase serotonin levels in the extracellular space, the therapeutic effects of the drug are delayed by several weeks...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2005-2007

Sted: Vestland

PSYKISK-Psykisk helse

Morphometric and functional MRI analysis

I have received funding for my Ph.D. research from the Norwegian Research Council and my main focus has been age differences in neuroanatomy, as measured by analysis of MRI (Magnetic Resonance Imaging) scans, cognitive function, as measured by neuropsycho logical tests, and electrophysiological f...

Tildelt: kr 44 499

Prosjektperiode: 2006-2006

Sted: Oslo

PSYKISK-Psykisk helse

Risk and protective factors for psychiatric disorders and symptoms among preschoolers: A prospective community study

1.Young children have psychiatric disorders and they endure. The rate of psychiatric disorders in early childhood is between 9% and 21%, which is comparable with rates at other ages. Moreover, there is a strong continuity of disorders and symptoms from ye arly childhood into later childhood and a...

Tildelt: kr 6,1 mill.

Prosjektperiode: 2005-2010

Sted: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

En undersøkelse av normal aldring og MCI ved bruk av nevropsykologiske mål, hendelsesrelaterte potensialer (ERP) og billeddiagnostikk (MRI)

Prosjektet har to relaterte deler. Del I fokuserer på normale aldringsprosesser, og representerer en videreføring av et igangsatt longitudinelt prosjekt om normal aldring (20-95 år) studert med nevropsykologi (NP), elektrofysiologi (ERP) og magneti c resonance imaging (MRI). Deltagerne har...

Tildelt: kr 1,6 mill.

Prosjektperiode: 2004-2006

Sted: Oslo

PSYKISK-Psykisk helse

Stress, sosialt samspill og RA: Betydningen av stress og støtte i interpersonlige og behandler-pasientforholdet ved RA

Problemstillinger: - Hvilke forhold knyttet til bakgrunnsvariable, sykdomskarakteristika og tidligere sykdomsforløp har betydning for sykdomsaktivitet og mental helse hos RA pasienter mer enn 10 år etter sykdomsdebut? Bidrar stress og psykologiske for hold gjennom sykdomsforløpet, basert på d...

Tildelt: kr 1,6 mill.

Prosjektperiode: 2004-2006

Sted: Oslo

PSYKISK-Psykisk helse

Nevrobiologiske aspekter ved tilbakevendende kortvarig depresjon (TKD)

BAKGRUNN: 1-års prevalens, av TKD er ca. 7%. Kjennetegn er mange (>12/år) og kortvarige (gj.snitt 3 dager) perioder med plutselig dyp depresjon og funksjonssvikt. Suicidrisikoen er 4.2 større enn i normalbefolkningen. TKD kompliseres ofte av angst, dysfo risk-utagerende adferd og nevrasteni. Deb...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2004-2007

Sted: Oslo

PSYKISK-Psykisk helse

Ullevål 600: Behandling, forløp, kognisjon og genetisk sårbarhet hos pasiente rmed alvorlig psykisk lidelse

Samarbeidsprosjektet vil kombinere fire delprosjekter, som studerer forløp og helsetjenestetilbud, medikamentell behandling, kognisjon og genetisk sårbarhet i et representativt materiale av pasienter med schizofreni og manisk depressiv lidelse. Det kognit ive og genetiske delprosjektet vil skje i...

Tildelt: kr 6,6 mill.

Prosjektperiode: 2004-2006

Sted: Oslo

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