0 antall prosjekter

KREFT-Offentlig kreftprogram

Molecular and biological characterization of cancer metastases

Purpose: Metastasis is the principal cause of cancer death, and for most tumor types staging, prognostication and therapy is inadequate. Hence, new knowledge on how to prevent metastasis and identification of predictive markers is among the most important challenges in cancer research. Our strat...

Tildelt: kr 6,7 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

PETROMAKS2-Stort program petroleum

Chemical exposures and cancer incidence in Norwegian offshore oil industry workers

Epidemiological studies have shown associations between work in the oil related industry and a variety of adverse health outcomes. Less knowledge is ,however, available on health effects among workers on installations. The few reports that exist indicate an excess of certain diseases among oil an...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Evaluation of functional Magnetic Resonance in the Diagnosis of Brain Tumors for Assessment of Clinical Efficacy (EMBRACE)

In patients suggestive of intra-cranial brain tumors, Magnetic Resonance (MR) is the imaging modality of choice for tumor characterization prior to, during and after surgical intervention. At Rikshospitalet (Oslo, Norway), a multi-disciplinary project has been established with the aim of develop...

Tildelt: kr 7,1 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Regulation and organization of chromosome replication and segregation in Escherichia coli.

In Escherichia coli, reinitiation at new origins is prevented by two different control systems. First, a process called sequestration makes newly formed origins unavailable to the initiation apparatus. The sequestration process involves membrane component s, SeqA protein and methylation at GATC s...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

KREFT-Offentlig kreftprogram

Understanding Breast Cancer Genomics; Towards combined molecular profiles for better diagnosis and treatment

We seek to reach a more fundamental understanding of the biological dynamics of breast cancer. High-throughput molecular data at multiple levels (eg DNA, mRNA, miRNA and protein level) have become available on increasing numbers of patients, and various m olecular profiles have been associated wi...

Tildelt: kr 10,5 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

STAMCELLER-Stamcelleforskning

The AlkB family of demethylases; putative roles in embryonic stem cell identity and epigenetic reprogramming of the germ line.

This project is initiated primarily based upon the intriguing phenotype and breeding pattern of Alkbh (AlkB homologs) targeted mice. Targeting of mouse Alkbh's (8 in total) cause various degree of sex-ratio distortion and developmental abnormalities incl uding asymmetric left-right eye developme...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

GLOBHELS-Global helse

Improved vaccination responses and optional immunomodulating therapy by adjuvant administration of COX-2 inhibitor in HIV-infected patients

This Proposal results from translational HIV research by the Applicants, ranging from basic research on signal transduction in lymphocytes that has firmly established cyclic AMP (cAMP) / protein kinase A type I alpha as a major inhibitor of antigen-specif ic activation; to basic clinical studies ...

Tildelt: kr 4,2 mill.

Prosjektperiode: 2009-2015

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

DNA glycosylases initiating removal of oxidative DNA base lesions in mammalian cells

Most mutagenic and carcinogenic agents induce covalent changes in the DNA structure and a large number of gene functions have evolved to effectuate repair or tolerance of such alterations without loss of viability or development of disease. DNA repair mec hanisms are probably the most important c...

Tildelt: kr 5,9 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

IS-NAD-Samarbeid med NORAD-land

Yosry, Mohammed. Egyptisk spesialist 2009

...

Tildelt: kr 20 515

Prosjektperiode: 2009-2009

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Analysing the function of CIN85 in development and carcinogenesis using Drosophila melanogaster as model organism

The aim of this project is to understand molecular processes governing epithelial and neuronal functions during normal development and in carcinogenesis using the fruit fly Drosophila melanogaster as a model system. We will analyze the function of the mul tiadaptor protein CIN85 and its associate...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Lung cancer - characterization of biological factors for use in diagnosis, prognostication and therapy

Lung cancer is the leading cause of cancer-related death. Treatment results depend on stage, but are overall poor, due to the fact that most patients are diagnosed with advanced disease, but also lack of understanding of involved cellular and molecular di sease mechanisms. From 2005, all lung can...

Tildelt: kr 5,6 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

KREFT-Offentlig kreftprogram

Somatic, translational and psychosocial research in long-term cancer survivors

Background: The number of long-term cancer survivors (LTCSs) (>5 years after primary treatment) is rapidly increasing and currently concerns >100,000 patients in Norway. Although frequently cured by their disease, the treatments and the cancers have late effects that impair the physical and ment...

Tildelt: kr 5,2 mill.

Prosjektperiode: 2009-2015

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Changes over time in cancer survival and mortality in an ageing Norwegian population and the significance of sociodemographic conditions

The substantial increase in the number of very old persons in Norway over the last decades has had a marked impact on the burden of cancer in our society. This project aims to generate knowledge on changes over time in cancer survival and mortality among the very old, here defined as persons 75 ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

KLINISK-Klinisk forskning

Randomized controlled trial of postpartum pelvic floor muscle training in women with injured and non-injured pelvic floor muscles.

175 førstegangsfødende kvinner med fødeplass Ahus har blitt tilfeldig inndelt i to gruppe: en som har trent bekkenbunnsmusklene 1 gang i uken i gruppe hos fysioterapeut + hjemmetrening hver dag og en gruppe som ikke har fått noe ekstra tilbud ut over å læ re riktig sammentrekning av bekkenbunnsmu...

Tildelt: kr 6,1 mill.

Prosjektperiode: 2009-2014

Sted: Akershus

PSYKISK-Psykisk helse

Psychotherapy Process Mapping Network: Identification of mediators, moderators, and change mechanisms to improve delivery of care

After decades of research, we do not have evidenced-based explanations for how or why psychotherapy works, and the ?greatest casualty of this lack of knowledge is the public at large? (Kazdin, 2008, pp 147). Although there is a large amount of theoretical explanation about effectiveness drawn fr...

Tildelt: kr 6,4 mill.

Prosjektperiode: 2009-2012

Sted: Buskerud

TJENESTER-Helse- og omsorgstjenester

User participation in decision making processes regarding medical treatment for cancer patients in a palliative stage.

This ethnographic study will describe and analyse the complexity of decision making processes regarding medical treatment for cancer patients in a palliative stage. This will entail deliberations about initiating, withdrawing or withholding life extending measures like chemotherapy, radiation, a...

Tildelt: kr 4,2 mill.

Prosjektperiode: 2009-2013

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neoadjuvant Avastin in Breast Cancer (Neo-Ava) - an integrated molecular approach to treatment biology.

I kliniske studier hvor en ønsker å avdekke hvilke pasienter som har nytte av en spesifikk behandling, er detaljerte analyser av svulstvevet både i forkant, under og etter behandling, av stor betydning. Likeledes kan andre analyser også kaste lys over effekten av en slik behandling, slik som fors...

Tildelt: kr 4,4 mill.

Prosjektperiode: 2009-2015

Sted: Oslo

FORNY-3-Kommersialisering av FoUresultater

Infrastrukturmidler 2009 - Helse Sør-Øst

Til tross for at helsesektoren har høy vitenskapelig produksjon er det liten tradisjon for å omsette forskningskunnskap i samfunnsnyttige produkter og tjenester. Det er derfor gledelig at Helse Sør-Øst har fokusert på innovasjon i sin nye 5-årige forskn ingsstrategi og utarbeidet en modell for ...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2009-2009

Sted: Innlandet

TJENESTER-Helse- og omsorgstjenester

A multidimensional support programme for family carers of persons with dementia - a 18 months randomised controlled intervention study

Dementia is a devastating disease. It leads to helplesness, no cure exist and there is a need for good quality care to improve the patients and the carers' situation and to delay nursing home placement. Psychosial intervention programmes carried out by h ighly academic educated therapist have sh...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2009-2014

Sted: Vestfold

STAMCELLER-Stamcelleforskning

Principles of stem cell pathway heterogeneity in tumor sub-populations

There is an ongoing debate on heterogeneity of stem cell parameters in tumor cells and the existence of tumor stem cells. The enclosed project proposal uses cell cycle parameters and stem cell pathways to analyze and determine mechanisms for creating and maintaining cell heterogeneity in tumors....

Tildelt: kr 3,0 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

STAMCELLER-Stamcelleforskning

Tissue engineering of hyaline cartilage

Cartilage injuries are frequent and lead to pain and disability. Unfortunately, articular cartilage shows a limited capacity for selfhealing and often goes on to osteoarthritis. Several surgical techniques have been developed to fill the cartilage defects , but so far none of them have been able ...

Tildelt: kr 7,7 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

RUSMIDDEL-Rusmiddelforskning

Dual diagnosis and compulsory treatment of alcohol and drug dependent patients in Health Region South, Norway.

Background: The Norwegian Social and Welfare Act of 1992 (LOST), opened for compulsory commitment of patients with serious alcohol and drug problems to inpatient care. Apart from one doctoral thesis, which dealt with the legal aspects, there are no Norweg ian studies in this field. Clinical resea...

Tildelt: kr 4,1 mill.

Prosjektperiode: 2009-2013

Sted: Agder

HELSEVEL-Gode og effektive helse-, omsorgs- og velferdstjenester

Implementing Online Patient-Provider Communication into Clinical Practice: Translational Research

Den internettbaserte Spørsmål og Svartjenesten (SoS) i denne studien er en tjeneste der pasientene kan sende meldinger til og motta svar fra sykepleiere, leger, ernæringsfysiologer og sosionomer etter sykehusinnleggelse eller poliklinisk konsultasjon. Meldingen fra pasienten mottas i en postkasse...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2009-2015

Sted: Oslo

HELSEVEL-Gode og effektive helse-, omsorgs- og velferdstjenester

Hospital at home and integrated care. The perspectives of relatives and municipality workers.

Den demografiske utviklingen med flere eldre og kronisk syke medfører fremtidige utfordringer for velferdsstaten og pårørende. Kunnskapsoppsummeringer har konkludert med at sykehusorganisert hjemmebehandling bidrar til bedre helseutbytte for pasientene og lavere kostnader. Prosjektet tar utgangsp...

Tildelt: kr 3,8 mill.

Prosjektperiode: 2009-2018

Sted: Akershus

IS-AUR-Samarb.progr. Norge Frankrike

Tallaksen, Chantal M E Aurora 2009 Fransk-norsk forskerutveksling

...

Tildelt: kr 45 000

Prosjektperiode: 2009-2010

Sted: Ukjent Fylke

IS-DAAD-Forskerutveksl. Norge-Tyskland

Waldminghaus, Torsten DAADppp 2009 Tysk-norsk forskerutveksling

...

Tildelt: kr 8 203

Prosjektperiode: 2009-2010

Sted: Oslo

MAMMOGRAFI-Evaluering av Mammografiprogr

Datautlevering fra Kreftregisteret

...

Tildelt: kr 0,30 mill.

Prosjektperiode: 2009-2009

Sted: Oslo

IS-NAD-Samarbeid med NORAD-land

Fell, Anne Kristin M. norsk spesialist til Kina 2008

...

Tildelt: kr 10 000

Prosjektperiode: 2008-2008

Sted: Telemark

TJENESTER-Helse- og omsorgstjenester

Discontinuation of antipsychotic and antidepressant in patients with dementia and BPSD living in nursing homes. A placebo controlled RCT.

Introduction: The prevalence of patients with dementia is high and many of them have Behavioral- and Psychological Symptoms in Dementia (BPSD). Treatments for BPSD are non-medical or medical therapy. Antipsychotic medication, acetylchollinesterase inhibi tors and antidepressant medication are al...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2008-2012

Sted: Innlandet

VERDIKT-Kjernekomp.og verdiskaping IKT

MEDICAL SENSING, LOCALIZATION, AND COMMUNICATION USING ULTRA WIDEBAND TECHNOLOGY

The project will develop ultra wideband (UWB) technology for improved wireless health technology, for both improved network communication and improved and possibly novel medical applications. Three major research directions are pursued, namely short range sensing and imaging, improved sensitivit...

Tildelt: kr 28,8 mill.

Prosjektperiode: 2008-2013

Sted: Oslo