0 antall prosjekter

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Analysing the function of CIN85 in development and carcinogenesis using Drosophila melanogaster as model organism

The aim of this project is to understand molecular processes governing epithelial and neuronal functions during normal development and in carcinogenesis using the fruit fly Drosophila melanogaster as a model system. We will analyze the function of the mul tiadaptor protein CIN85 and its associate...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanisms for state-dependent changes of thalamic processing

Thalamus contains nuclei in sensory and motor systems that control the major gateways to cerebral cortex in a two-way dialogue with cortex. The nuclei pre-process, synchronize and modulate cortical input depending on behavioral states like sleep, wakefuln ess, arousal, and vigilance. In awake, at...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

IS UBIQUITINATION REQUIRED FOR ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR?

Over-expression of receptor tyrosine kinases in the epidermal growth factor receptor (EGFR) family (ErbB proteins) drives carcinogenesis and cancer progression. This is due to growth promoting and anti-apoptotic signalling. Down-regulatory mechanisms are operating poorly in several cancers. This...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Chromatin rearrangement during differentiation of mesenchymal stem cells in the context of nuclear envelope-linked diseases

The nuclear envelope contributes to regulating genome function by interacting with DNA and chromatin. Mutations in a subset of nuclear envelope proteins, the lamins, cause debilitating diseases including lipodystrophies, muscle dystrophies and premature a ging. The link between lamin mutations an...

Tildelt: kr 5,5 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structure, function and phylogenetics of cytochrome oxidase in Neisseria species

Pathogens and parasites, like all other forms of life, have evolutionary histories. Elucidating these histories using phylogenetic methods is of immense importance as it provides knowledge concerning the mechanisms of infectious disease pathogenesis and h ow diseases might be controlled or ideall...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Coral Reef Fish Coloration: Sexual Selection, Diversity and Speciation [revised Jan. 09]

Tropiske korallrev er blant verdens mest truete livsmiljøer. Korallrevene er samtidig "havets regnskoger", med et større biologisk mangfold enn noe annet havmiljø. Bare et fåtall av dyr og planter på korallrevene er studert - de aller fleste vet vi ingenting om. Prosjektet CoralFish har hatt som ...

Tildelt: kr 6,6 mill.

Prosjektperiode: 2009-2016

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structure, Function and Regulation of NAD Kinases

The availability of NADP represents a key prerequisite for cellular functions. Besides its role in bioenergetic conversions, this nucleotide also serves in signalling pathways. The reduced form, NADPH, plays a pivotal role for the maintenance of cellular integrity, because it provides the reduci...

Tildelt: kr 6,1 mill.

Prosjektperiode: 2009-2013

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The muscle excitation-transcription coupling

The composition of muscle is related to the risk of developing life style diseases such as obesity and type II diabetes. Muscle is a permanent tissue, but the phenotype can nevertheless be changed by changing the pattern of activity such as by exercise. C hanges in the pattern of action potential...

Tildelt: kr 6,2 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular mechanisms of androgen action

Androgens are essential for a wide range of important biological processes. These include the development and maintenance of male reproductive organs, hair cycle and skeletal muscle, as well as regulation of lipid metabolism and bone remodelling. Androgen s are implicated in pathological processe...

Tildelt: kr 6,2 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EXPLORATION AND VALIDATION OF ANGIOGENESIS MARKERS IN HUMAN CANCERS

Nydanning av blodårer og interaksjon mellom svulstceller og blodkar er viktige faktorer for svulsters vekst og spredning. Endel svulster kan behandles ved å blokkere deres blodsirkulasjon, slik det ble foreslått av Folkman i 1971. Medikamenter som motvirker nydanning av blodårer er godkjent for k...

Tildelt: kr 7,6 mill.

Prosjektperiode: 2009-2016

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The genetic basis of response to selection in natural bird populations - insight from state-of-the-art genomics analyses.

The natural environment of most natural plant and animal species is today changing fast as a consequence of human activities. Examples include environmental threats due to global warming, habitat fragmentation, and introduction of alien species. To cope w ith such threats and persist, populations...

Tildelt: kr 4,6 mill.

Prosjektperiode: 2009-2013

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Hepatocyte Growth Factor in the Pathogenesis of Multiple Myeloma

Since our publications in 1996 showing that malignant plasma cells (MM cells) usually express both HGF and its receptor c-Met, a growing number of reports have implicated HGF/c-Met in the biology of MM. For instance, high levels of HGF in serum of MM pati ents predict a bad prognosis and correlat...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2009-2012

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Spatiotemporal Regulation of cAMP Signalling in Health and Disease

Signalling networks involving the signal molecule cAMP and protein kinase A (PKA) are involved in regulation of a multitude of body functions involving most organ systems of the body. An emerging principle is that function of the cAMP signal pathway in th ese settings requires subcellular anchori...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Maturation of the electrophysiological and intracellular signaling systems in teleost gonadotropes during puberty

Hovedmålet til dette prosjektet er å belyse hvordan reguleringsmekanismen til de hormonproduserende gonadotrope cellene i hypofysen modnes under pubertetsutviklingen, med fokus på komponenter som deltar i elektrofysiologisk signalisering trigget av frigjø ringshormonet GnRH. Vi bruker torsk og me...

Tildelt: kr 6,6 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

State-dependent control of LTP consolidation

REM sleep is essential for normal cognitive function and required for long-term memory formation in both humans and rodents. Deprivation of REM sleep after LTP induction impairs LTP consolidation. Thus, REM sleep may represent a preferred off-line state o f neural networks for the modulation of s...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2009-2012

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cytokine- and stress-induced myocardial hypertrophy

Myocardial hypertrophy can be induced through hormonal factors or stress-sensing molecules. Hence, it is necessary to study the activation and function of such hypertrophic mediators to completely understand the biological processes occurring during devel opment of heart failure. We will combine ...

Tildelt: kr 6,3 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Entorhinal circuits and memory functions

Several decades of research has convincingly indicated that the entorhinal-hippocampal system is a key component of circuits in the brain mediating episodic memory. Using rats as models, we have learned how memories may become encoded, stored and retrieve d. Focus has been on the hippocampus and ...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2009-2012

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Reconstruction of past ecosystems by barcoding DNA preserved in permafrost

Recent advances in ultra-high-throughput DNA sequencing technology and in species identification (?barcoding?) tools based on ancient DNA preserved in permafrost soils are opening up a novel research avenue for paleoecological reconstruction. In this proj ect, we will develop new DNA barcoding ma...

Tildelt: kr 9,5 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Dissecting molecular properties of honey bee vitellogenin (Vg): a protein acting at the intersection between social behavior and aging

The honey bee provides opportunities for cutting-edge studies of the molecular basis for complex social traits. Our group has made substantial contributions to the understanding of honey bee behavior and aging by identifying a socially controlled pathway that affects social activities and aging r...

Tildelt: kr 4,1 mill.

Prosjektperiode: 2008-2012

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Salmon lice as models for understanding life history evolution of parasites

Salmon lice represent an important problem both in relation to fish farming and to the conservation of wild salmonids. It is now estimated that at least 95 % of all salmon lice eggs in the sea come from farmed fish. The majority of salmon lice have ther efore changed their resource base from wi...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2008-2014

Sted: Vestland

FRIBIO-Biologi og biomedisin

14th International Symposium on Cells of the Hepatic Sinusoid: Integrating Basic and Clinical Hepatology, Tromsø 2008

The discipline of hepatology has traditionally been centered mainly around the hepatocyte, that makes up more than 70% of the total number of liver cells and 90% of the liver volume. Cells and functions relating to the bile system have also been a central part of hepatology. However, the cells o...

Tildelt: kr 0,25 mill.

Prosjektperiode: 2008-2008

Sted: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Activity-dependent plasticity in visual cortex

A major question in neuroscience is how appropriate connections are formed when the brain develops. It is well established that neural circuits are fine-tuned by experience during 'critical periods' in early postnatal life. In the visual system, closing o ne eye for only a few days during a criti...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Speciation processes in fungi examined through experimental and empirical approaches

Although more than 100.000 fungal species exist, fungi are largely missing in the speciation debate. Speciation theory is based mainly on research on animals and plants and little is known whether fungi conform to general models of speciation. Four differ ent boreal/nemoral wood-decay species com...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Plastids as cellular reservoir for nuclear transcription factors

Transcription factors are responsible for the transcription of the genetic information and are therefore key molecules in any cell. In plant cells the genetic information is divided into three sub-genomes (nuclear, plastid, mitochondrial) that are depende nt on each other. The description of a eu...

Tildelt: kr 4,2 mill.

Prosjektperiode: 2008-2013

Sted: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Incipient speciation through ecological divergence in subarctic whitefish populations

The evolutionary processes that can create two species out of one are still under exploration and continuous debate. Recent developments have emphasised the potential of ecological speciation where species divergence may develop as an evolutionary consequ ence of ecological interactions within th...

Tildelt: kr 4,6 mill.

Prosjektperiode: 2008-2012

Sted: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Exploiting the plasticity in social life history; physiology of extreme longevity in honeybee diutinus workers

Our studies have documented direct effects of vitellogenin on stress resistance and longevity during summer. However, although vitellogenin RNAi in workers living under favorable ambient conditions provides functional insight, it does not directly address the role of vitellogenin in extreme work...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2008-2013

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cellular interactions underlying organization of cortical circuits

A major question in neuroscience is how appropriate connections are formed when the brain develops and how these connections are modified with experience. It is well established that neural circuits are fine-tuned by experience during 'critical periods' i n early postnatal life. In the visual sys...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

B-cell lymphomagenesis in Ung-deficient mice: collaboration between chronic antigenic stimulation and DNA repair deficiency

The importance of responding appropriately to DNA damage is highlighted by the frequent development of human disease, most notably cancer, in cells where this response is compromised. Here, we ask whether endogenous DNA damage, such as uracil in DNA, can contribute to activation of the DNA damage...

Tildelt: kr 6,4 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Identification of molecules involved in the generation of the MHC class II peptide loading compartment.

Visualization of vesicular trafficking has become possible by the rapid development of imaging techniques that utilize fast computers and fast on line imaging systems. Biologically we have developed a system for studying trafficking events in the immune specific intracellular pathway towards the...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

FRIBIO-Biologi og biomedisin

EMBO Conference on the replication and segregation of chromosomes

We will organise a high-quality scientific meeting to exchange information in the field of chromsome replication and segregation. This field of research is important for many reasons, for the fundamental understanding of the basic aspects of cellular grow th and proliferation as well as for an un...

Tildelt: kr 0,20 mill.

Prosjektperiode: 2008-2008

Sted: Oslo