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Hovedmålet med kreftbehandling er å eliminere kreftceller og dette er tradisjonelt oppnådd ved kirurgi, bruk av giftige medikamenter (cellegift) og stråling. En ny og betydningsfull tilnærming til kreftbehandling kalt immunterapi, har derimot fått mye oppmerksomhet det siste tiåret; Her forsøker leger og forskere å utnytte immunsystemet vårt for å målrettet  ødelegge kreftceller. En nøkkelaktør i denne banebrytende tilnærmingen er en gruppe «drapsmenn» i immunsystemet kjent som cytotoxiske T-lymfocytter (CTL-er). Disse cellene har en bemerkelsesverdig evne til å oppdage kreftceller ved å gjenkjenne unormale molekyler på overflaten av kreftcellene - molekyler som friske celler ikke har. Når CTL-er gjenkjenner kreftcellene ødelegger de dem ved å frigjøre giftige molekyler som initierer kreftcellenes selvdestruksjon. 
 
Selv om betydelige innsats har blitt dedikert til å forstå hvordan CTL-er aktiveres og hvordan de gjenkjenner kreftceller, vet vi mindre om de påfølgende hendelsene inne i kreftcellene som fører til deres død. Fra før vet vi at CTL-er kan initiere to forskjellige typer celledød i kreft: den første, kalt apoptose, er en stille og ordnet prosess der kreftcellene krymper og brytes opp uten å varsle immunsystemet; den andre, kalt pyroptose, er en mer dramatisk prosess som involverer dannelse av åpninger i cellemembranen, noe som fører til at cellene svulmer opp og sprekker. Under denne cellebristen blir innholdet inne i cellene frigitt i omgivelsene, og dette kan fungere som 'faretegn' som kan stimulere en sterkere immunrespons mot kreftcellene. Betydningen av denne cellebristen for å forsterke anti-tumorresponsene vil bli undersøkt i dette prosjektet. 
 
Videre er vi fascinert av muligheten for å avdekke ytterligere, ennå ukjente, former for celledød indusert av CTL-er. Utforsking av disse dødsrelaterte prosessene i kreftcellene kan potensielt øke effektiviteten av immunterapi og bidra betydelig i den pågående kampen mot kreft.

The primary goal of most cancer therapies is to induce cancer cell death. Immunotherapy relies on the cytotoxic activity of lymphocytes such as natural killer cells (NKs) and cytotoxic T lymphocytes (CTLs) to achieve this. While a significant amount of research in immunotherapy focuses on the events within cytotoxic lymphocytes or at the interface between cytotoxic lymphocytes and cancer cells, less is known about the molecular mechanisms that orchestrate cancer cell death, particularly in the case of CTL-mediated death.
CTLs are known to induce two types of cell death in cancer: non-inflammatory apoptosis and proinflammatory pyroptosis. Pyroptotic cancer cells release proinflammatory signals that attract immune cells to the tumor site, thereby enhancing the anti-tumor response. Cell lysis is a common outcome of pyroptotic cell death. It is unclear whether lysis can be decoupled from pyroptosis in cancer cells and whether the proinflammatory properties of pyroptotic cancer cell death depend on lysis. Moreover, it remains unknown whether CTLs can induce other forms of cell death in cancer, apart from apoptosis and pyroptosis.
Studying the mechanisms of CTL-mediated cancer cell death is challenging because CTLs selectively target cells expressing specific antigens. However, given the critical role of CTLs in immunotherapy, it is essential to deepen our understanding of CTL-induced cancer cell death.
This project aims to develop novel methodologies to investigate the death mechanisms that are initiated by CTLs. In addition, we will identify new pathways and mediators involved in CTL-induced cancer cell death. Furthermore, we will assess the contribution of proinflammatory cell death and lysis in promoting anti-tumor responses in vivo. Overall, this research will improve our knowledge of the molecular mechanisms of CTL-mediated cancer cell death and potentially reveal novel targets to enhance the efficacy of cancer immunotherapy.

T-cell-mediated proinflammatory cell death and lysis in cancer

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

WHeelchair Activity Monitoring project (WHAM)

Algebraic Theory of Information Quantities

Information theory is a discipline at the intersection of statistics, engineering and computer science. As the study of information quantities, such as compression or communication capacities, information content or measures of statistical dependency, it is one of the theoretical underpinnings of data science.

Computational problems in information theory are highly non-linear. The goal of this project is to transfer state-of-the-art methods of computational non-linear algebra to information theory, to study the inherent algebraic complexity of information-theoretical problems and to provide tools for solving them in practice. The algebraic point of view has proven to be fruitful in seemingly unrelated areas, as witnessed by a surge of recent work in algebraic statistics, in particular on likelihood geometry. However, maximizing the likelihood function is the same as minimizing relative entropy — a specific information quantity. Hence, this project also aims at generalizing the techniques developed in likelihood geometry.

One focus is on the practical computation of information quantities using numerical and differential algebraic geometry. Such quantities are defined via non-linear optimization problems and we aim to pinpoint the algebraic complexity of these problems in instances of general interest, such as common information measures. The final objective is finding fundamental laws and limits of data science imposed by non-linear inequalities constraining the entropic region. These inequalities provide, by duality, universal bounds for many of the optimization problems studied in information theory.

Per- og polyfluorerte stoffer (PFAS) er en stor gruppe menneskeskapte kjemikalier med høyt fluorinnhold som antas å ha negative helseeffekter. Kilder til PFAS kan være produksjon av vann-, varme- og flekkbestandige produkter og disse kjemikaliene er en del av hverdagen vår. PFAS påvirkning av biologiske systemer er ikke fullstendig forstått. Noen PFAS er antatt å øke risikoen for å utvikling av ikke-alkoholisk fettleversykdom (NAFLD) og øke risikoen for diabetes. 

For å forstå hvordan PFAS påvirker organene våre ønsker vi å bruke små laboratoriedyrkede organmodeller, kalt organoider. Disse miniatyrorganene kan dyrkes fra menneskelige stamceller og tilbyr et kontrollert miljø for å studere hvordan PFAS påvirker f.eks lever og bukspyttkjertelen vår, uten bruk av dyreforsøk.

For å studere helseeffekter må vi kunne måle nivået av biomolekyler som fettstoffer i leveren og hormoner i bukspyttkjertelen. Til dette trenger vi å utvikle analytiske verktøy for å måle effektene. Først vil vi bekrefte at når leverorganoidene eksponeres for enkelte PFAS-forbindelser utvikles det NAFLD-lignende sykdom ved å sammenligne den biokjemiske profilen (proteiner og metabolitter) til organoider av lever med PFAS-eksponerte organoider. Deretter vil vi utvide den analytiske verktøykassen for å undersøke hvilke metabolske veier som påvirkes, og om effekten er den samme i NAFLD-induserte og PFAS-eksponerte organoider. Vi vil også eksponere insulinproduserende bukspyttkjertelorganoider for PFAS for å undersøke effekten av PFAS på hormonproduksjon. Når effektene av PFAS-eksponering på lever- og bukspyttkjertel-organoider er etablert, vil organoidene bli samkultivert i en chip, og effektene av PFAS-eksponering vil bli undersøkt og sammenlignet med individuelle organoider.

Persistent organic pollutants (POPs) are believed to contribute to metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD) and type 1 diabetes. HE-POP aims to investigate the effects of per- and polyfluoroalkyl compounds (PFAS), a type of POPs), on organ function in a controlled environment.

Organoids are multicellular laboratory-grown miniature organs, that are grown from stem cells. HE-POP will use organoids to examine how PFAS affects our organs and develop cutting-edge bioanalytical tools and methodology to measure these effects using liquid chromatography-mass spectrometry. HE-POP hypothesizes that PFAS negatively affects organ function, as evidenced by changes in hormone and lipid levels characteristic of NAFLD and type 1 diabetes. 

Organoids offer a controlled environment to study the effects of PFAS on the liver and pancreas, without the use of animal models. HE-POP aims to gain evidence of the negative effects of PFAS on organ function through controlled experiments on organoids and aid in understanding the biological mechanisms underlying NAFLD and type 1 diabetes.

HE-POP has fundaments in UN sustainable development goals, specifically #3, #12, and #14/15, seeking an understanding of diseases with worldwide prevalence, and understanding how POPs affect our life and surroundings and help enable the right regulatory actions and replacement chemicals.

HE-POP: Studying the Health Effects of Persistent Organic Pollutants, Using Mass Spectrometry, Organoids, and Organ-On-A-Chip

Norge har under Parisavtalen påtatt seg en forpliktelse til å redusere klimautslippene sine med minst 55 prosent innen 2030 sammenlignet med nivået i 1990. Hittil har vi kun oppnådd 5 prosent av dette målet; vi har følgelig kun syv år på å redusere de resterende 50 prosent for å imøtekomme målene. For 2050 har vi satt oss enda større mål: å redusere klimautslippene med hele 90 prosent. Bakgrunnen for målene er at vi prøver å unngå de verste scenarioene FNs klimautvalg skisserer opp i sine rapporter. I tillegg har energiforbruket økt, og prognosene fra Statnett for ulike scenarier viser at energiforbruket skal fortsette å øke. Vi trenger følgelig mer energi. Dette har bidrat til at diskusjoner rundt kjernekraft i Norge er høyaktuelle og pågående. Norsk Kjernekraft AS har blitt opprettet med formål om å bygge Norges første kjernekraftverk. I tillegg ble det i fjor også bevilget 200 millioner kroner fra Regjeringen til et nytt senter som skal drive med nukleær forskning. Målet er å styrke den norske kunnskapsberedskapen på det nukleære området. Dette betyr at vi beveger oss i en retning hvor kjernekraft en dag kan bli aktuelt i Norge, og noen mener at dette er den eneste veien å gå hvis vi skal nå målene våre for 2050. Men i dag sitter vi med flere spørsmål enn svar, blant annet: Hvilken teknologi og leverandør burde vi velge? Er regelverket for snevert og strengt? Hvordan kan dette gjøres og samtidig ivareta sikkerhet? Hvordan tjener et kjernekraftverk penger?

Dette prosjektet skal svare på samtlige av disse spørsmålene i en detaljert og omfattende analyse. Her bruker vi grunnlagsdata til å vurdere dagens forskning opp mot hvordan industrien i andre land opererer, og ut ifra dette forsøke estimere hva risikoen knyttet til å bygge kjernekraft som industri i Norge er. Prosjektet sikter på å gi et så helhetlig bilde som mulig slik at vi kan gjøre oss opp en mening basert på fakta; om kjernekraft passer inn i miksen av det som utgjør norsk energi.

Denne prosjektbeskrivelsen skisserer forskningen Vala Maria Valsdottir (omtales herunder som stipendiaten) skal utføre innenfor sin doktorgradsavhandling. Prosjektet skal være en del av Senter for nukleær forskning (SNF) som fikk midler vinteren 2023.
Ph.d.-prosjektet er initiert av Inmeta Consulting AS, som igjennom denne ph.d.-stillingen vil bli en del av SNF. Inmeta planlegger en prosjektperiode på fire år, hvor stipendiaten arbeider 75 % med ph.d.-prosjektet og 25 % med vanlig virksomhet hos Inmeta. 
Prosjektet skal undersøke muligheten for kjernekraft som industri i Norge. Dette er både en samfunnsaktuell problemstilling samt en som medlemmene i SNF er interessert i å utforske. Stipendiaten kommer derfor til å samarbeide med alle aktørene som er involvert i senteret og benytte forskningsdata fra dem. Dette gjelder da spesielt Institutt for energiteknikk (IFE) som har mest grunnlagsdata som er relevant for dette prosjektet.
Kandidaten ferdigstilte en masteroppgave høsten 2020 i kjernefysikk på Universitetet i Oslo (UiO) og har derfor gode og relevante grunnkunnskaper for å ta på seg et slikt prosjekt. I tillegg har kandidaten tre års erfaring innenfor energibransjen, og er derfor oppdatert på industrien og forstår deres problemstillinger godt.

Er kjernekraft aktuelt for Norge?

InART is recognized as one of the main conference series in the field of Heritage Science and since its first edition in 2013 (Evora, Portugal) it mainly focused on the contribution of natural sciences to the field. A major change occurred after the COVID-19 pandemic, when a greater number of researchers from different branches of heritage science participated in InART 2022 (Paris, France). 
InART is an open platform for knowledge-sharing among professionals in the field of Heritage Science, including conservation.
These aspects are covered by the main conference topics:
•	Development of new tools (devices, technology, software, etc.), advanced data analysis and FAIR data management
•	Development and/or implementation of new methods and routines (diagnostic and conservation) for the understanding of heritage materials, techniques, and degradation processes (chemical, physical and biological)
•	Development, testing (includes mechanical testing), and characterization of new materials for conservation (special attention to green conservation treatments)
•	Application of non-invasive/non-destructive techniques
•	Preventive conservation: environmental monitoring techniques and climate/microclimate effects on the conservation of heritage sites and exposed objects.

Heritage science is a highly multidisciplinary research field. Consequently, topics covered during the InArt2024 conference can be approached from different points of view and the conference aims to merge natural sciences and conservation, providing a dynamic space for active interaction, scientific exchange, and debates on the central issues of heritage science research. InART2024 welcomes contributors from diverse fields to join and create an interdisciplinary discussion about cultural heritage conservation within the fields of archaeological objects, artworks, built heritage, etc.

6th International Conference on Innovation in Art Research and Technology

Applied Biocatalysis is the development through science and engineering of useful biological catalysts and their commercial applications. The BNCM 2024 conference has an intention to gather approx. 100 international and national scientists from academia and industry in addition to PhD students from the international community. BNCM 2024 will be the 7th in this series of meetings with attendees from both academia and industry presenting and discussing the newest research in enzyme catalysed reactions in other media than water. The conference series was started in 1986 by professors Hans Tramper and Urs von Stockar, University of Wageningen, the Netherlands, and has later been chaired in Russia, Italy and Germany before Elisabeth Jacobsen at NTNU was give the honor of chairing the conference.  Collaboration in biocatalysis research has been supported by EU Frameworks as three subsequent COST actions. The first action, COST Action D25 "Applied Biocatalysis. Stereoselective and environmentally friendly reactions catalysed by enzymes " (2001-2007) was initiated and chaired by professor Thorleif Anthonsen, NTNU, the founder of the Biocatalysis Group at NTNU, which the project leader of this conference now chair. The strategy of applied biocatalysis fits well under the definitions of white biotechnology and Sustainable chemistry (Suschem) and fits also well with the EU Green Deal Strategy.

7th International Conference on Biocatalysis in Non-Conventional Media

End-to-End Green House Gas (GHG) Monitoring Service

Sustainable cultivation of polychaetes as feed in aquaculture

InterNASH - An intercellular-pathway therapeutic for non-alcoholic steatohepatitis

Halthet hos storfe: økt kunnskap og digital halthetsvurdering for å fremme god dyrevelferd og bedre forvaltningspraksis.

Midlene fra OFFPHD-Offentlig sektor-ph.d. fordelt på år

Midlene fra OFFPHD-Offentlig sektor-ph.d. fordelt på fylker

Midlene fra OFFPHD-Offentlig sektor-ph.d. fordelt på fagområde

Seniorinspektør

Lameness is a major cause of suffering in farmed ruminants. However, the prevalence, causes and risk factors for lameness in Norwegian beef cattle are unknown. Internationally studies have scored the locomotion pattern of dairy cows and correlated the score to foot pathology. However, there is only one published study in beef cattle. Understanding lameness in beef cattle is particularly important for the Norwegian Food Safety Authority (NFSA) as the national competent body for animal welfare. The lack of a specific, robust, and repeatable lameness scoring makes the application of policy and policing of legislation open to criticism about a potential lack of objectivity.  
Disruptive sensor technology can assess lameness objectively on farms. It is imperfect but provides a standardised repeatable method of assessing lameness which could be employed in all slaughterhouses throughout Norway to assess lameness automatically and consistently throughout Norway. The available technologies are untested in slaughterhouses. 
Approximately 10% of adult cows entering the food chain in Norway are slaughtered on farm as emergency slaughter. On farm emergency slaughter (OFES) certification has been investigated and it has been found that lameness has been given as the cause in approximately 50% of the cases by veterinarians in the field. However, the reports of lameness have never been investigated. 
This project aims to improve the NFSA’s ability to protect animal welfare and food safety by increasing the knowledge about lameness in beef cattle. To achieve this the project aims to:
1)	Estalblish the incidence of lameness in Norwegian beef cattle
2)	Identify the incidence of foot lesions in Norwegian beef cattle
3)	Identify herd level risk factors for lameness in Norwegian beef cattle
4)	Estalblish if sensor technology can be used to identify lame cattle on arrival to a slaughterhouse
5)	Identify the pathological lesions seen in cattle which have undergone OFES.

Lameness is recognised as a major cause of suffering in farmed ruminants. Lameness in dairy cows has received considerable attention. The scientific knowledge of lameness in beef cattle is limited. Internationally many studies have investigated the locomotion pattern of dairy cows and tried to allocate repeatable scores to the locomotion patterns seen and correlated these to foot pathology. However, there is only one paper investigating this problem in beef cattle that was published last year. The scale used is different to the one most commonly for dairy cattle, which demonstrates the need for further work in this area. This is particularly important for the Norwegian Food Safety Authority given its roles in animal welfare both on farm, under transport and at the slaughterhouse. The lack of a specific, robust, and repeatable lameness scoring makes the application of policy and policing of legislation with regards to on farm animal welfare and transport of animals open to criticism about a potential lack of objectivity.  
Disruptive technology is becoming available to detect lameness objectively. Sensor systems can be used to accurately identify lameness in dairy cows on farm. The systems do not provide perfect correlation with human observers, who have been used as the ‘Gold Standard’. However, they provide a repeatable and objective method of assessing lameness. It is possible that sensor systems could be employed when both loading or unloading animals to provide a ‘real-time’ assessment of lameness. 
To summarise the knowledgaps in terms of beef cattle lameness. 
We do not know: 
1) the incidence or prevalence of lameness, either at slaughter or on farm; 
2) the causes of, and risk factors for, lameness in Norwegian beef cattle; 
3) the extent to which sensor technology can automate and/or improve the assessment of lameness in beef cattle at a slaughterhouse; 
4) the causes of lameness resulting in emergency slaughter because of lameness in beef cattle.

Beef cattle lameness: increased knowledge and use of sensor technology to improve animal welfare and legislattion practice.

The overall vision of the Women TechEU project is to pave the way for future participation in EIC calls with our novel bio-inspired robotic fishlike autonomous underwater vehicle. The patented (US 10882591 B2) mechanical design, size and flexible tail mimic the gentle undulating motion of a swimming fish with utmost power efficiency. MFAAS unobtrusively collects and delivers real-time visual and environmental data to the Aquaai web dashboard. Affordable to all Blue Economy and R&D users, MFAAS provides data to protect marine and freshwater ecosystems in a climate challenged world. MFAAS navigates via GPS waypoints, computer vision and artificial intelligence, carrying up to sixteen different sensors that capture visual, biological, environmental, and geological data – including pH, O2, temperature, salinity, sonar, acoustic, visible light and IR cameras. MFAAS weighs 20kg and can manoeuvre in confined spaces, around coral reefs and subsea structures, in calm or turbulent rivers and open seas.

Our MFAAS technology has a major market potential compared to current state-of-the-art technologies. The Women TechEU grant will support activities such as upgrading the business model, updating the business plan and growth strategy, finding partners and investors, market validation, etc.

Aquaai Women TechEU PES 2021

The overall vision of the MFAAS Accelerator project is to prototype, pilot and commercialise our novel bio-inspired robotic fishlike autonomous underwater vehicle. The patented (US 10882591 B2) mechanical design, size and flexible tail mimic the gentle undulating motion of a swimming fish with utmost power efficiency. MFAAS unobtrusively collects and delivers real-time visual and environmental data to the Aquaai web dashboard. Affordable to all Blue Economy and R&D users, MFAAS provides data to protect marine and freshwater ecosystems in a climate challenged world. MFAAS navigates via IMUs, DVL, visual odometry, GPS, computer vision and artificial intelligence, carrying up to 16 different sensors, two POE cameras and one depth camera that capture visual, biological, environmental and geological data – including pH, DO, EC, ORP, nitrate, temperature, salinity, acoustic, luminosity, bathymetric and RGB-D images. MFAAS weighs 20kg and can manoeuvre in confined spaces, around coral reefs and subsea structures, in calm or turbulent rivers and open seas.

Our MFAAS technology has a major market potential compared to current state-of-the-art technologies. To increase our commercial success and impact, we have created a Strategic Business Plan, as a detailed roadmap, describing all necessary activities we need to undertake to ensure a successful market introduction. Now, we seek to develop our Commercialisation Plan (CP), which will form an important part of the final Business Innovation Plan (BIP), to be created in this Accelerator project. As the envisaged Accelerator project builds upon a validated prototype technology, most of our efforts will be focused on piloting and commercialisation activities.

Aquaai MFAAS ACC PES 2021

Our patented fishlike autonomous underwater vehicle provides companies operating in the blue economy with a rugged and affordable technology for tracking and analysing their marine operations, especially for aquaculture farmers, observing and monitoring their livestock. At Aquaai Norway AS, we have combined current sensors and technologies into a one autonomous moving platform, offering an “all in one” solution able to provide superior analytics, while still being affordable. The robot is produced using 3D printed components, off the shelves cameras and sensors, which results in its affordability, while being easily transportable and requiring little to no crew to operate. It uses Computer Vision to obtain data on its surroundings, and through a floating communication hub, transfer the data online for analysing and visualisation. By having a fish like design and movement, we avoid stressing farmed salmon, which otherwise are prone to dying from stress induced heart attacks when new variables are introduced in their living environment. The farmer benefits from more precise continuous data streams around stock behaviour and health, water quality and feed optimization.
The aim of the envisaged project is to move our current prototype technology to TRL8. The Myriad FAAS technology has a major market potential compared to current state-of-the-art technologies. To increase our commercial success and impact, we have created a Strategic Business Plan, as a detailed roadmap, describing all necessary activities we need to undertake to ensure a successful market introduction. Now, we seek to develop our Commercialisation Plan (CP), which will form an important part of the final Business Innovation Plan (BIP), to be created in this Accelerator Pilot project. As the envisaged Accelerator Pilot project builds upon a validated prototype technology, the majority of our efforts will be focused on piloting and commercialisation activities.

0 antall prosjekter

PES-HORISONT-EU-PES Horisont Europa

Aquaai Women TechEU PES 2021

Tildelt: kr 49 999

Prosjektperiode: 2021-2022

Sted: Nordland - Nordlánnda

PES-HORISONT-EU-PES Horisont Europa

Aquaai MFAAS ACC PES 2021

Tildelt: kr 74 999

Prosjektperiode: 2021-2021

Sted: Nordland - Nordlánnda

PES2020-Prosj.etabl.støtte H2020

Myriad FAAS - First Fish-as-a-Service untethered robotic fish platform.

Tildelt: kr 74 999

Prosjektperiode: 2020-2020

Sted: Nordland - Nordlánnda