0 antall prosjekter

Dato fra ny til gammel

FUGE-Funksjonell genomforskn.i Norg

Improved immunity of aquacultured animals

Based on important disease models, this project concerns development of a technological knowledge platform for a future improved immunity to infectious pathogens in the major aquacultured species in Europe (Atlantic salmon, rainbow trout, sea bream, sea b ass, carp, mussel and oyster). Focus will...

Tildelt: kr 0,15 mill.

Prosjektperiode: 2005-2007

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Tilleggsstøtte til EU prosjekt: Glutamate receptor interacting proteins as novel neuroprotective targets

Excitotoxicity contributes significantly to neuronal cell death in a number of neurological conditions including stroke, head trauma, and Huntington’s disease. The recent discovery of the proteins that anchor and interact with glutamate receptors opens fo r a new strategical approach to cytoprote...

Tildelt: kr 1,00 mill.

Prosjektperiode: 2005-2007

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Funksjonelle studier av genekspresjon in vivo ved inflammatoriske sykdommer

The Blomhoff group was deeply involved in the application of the FUGE platform on transgenic mice, and the organisation of the platform. The described project builds on the expertise offered by the FUGE platform. Hallmarks of inflammation include activa tion of gene expression through the trans...

Tildelt: kr 0,50 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Selection and characterization of novel cancer specific antibodies – utilization in diagnostic and therapeutic approaches

Objective: The main purpose is to identify and characterize novel breast cancer specific antibodies. Interesting candidates will be thoroughly characterized for their specificity. Fulfilling the specificity criteria their potential as diagnostic or progno stic markers will be investigated. Finall...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2005-2010

Sted: Ukjent Fylke

GNBIO-Grunnleggende næringsrettet bioteknologi

Novel biologically active molecules through a combined application of bioinformatics and genetic engineering

The proposed research project is intended to further develop and test a unique drug discovery platform created at the NTNU/SINTEF (Norway) and the Institute of Biomedical Chemistry (Russia), which is composed of a powerful new bioinformatics tool and a te chnology for gene manipulation of antibio...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2005-2009

Sted: Trøndelag - Trööndelage

GNBIO-Grunnleggende næringsrettet bioteknologi

Enzyme evolution and advanced strain engineering in biorprocess development

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Tildelt: kr 8,2 mill.

Prosjektperiode: 2005-2011

Sted: Trøndelag - Trööndelage

GNBIO-Grunnleggende næringsrettet bioteknologi

RNA interference targeting Tissue Factor, a novel principle for cancer therapy.

The principal goal of this project is to explore the use of RNA interference (RNAi) technology in cancer therapy using Tissue Factor (TF) as a target. The project is based upon recent advances in RNAi technology and in our understanding of the role of TF in cancer cell biology. The cloning of T...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

FORNY-3-Kommersialisering av FoUresultater

Ny digital teknologi for måling av trykk på mennesker og dyr

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Tildelt: kr 0,50 mill.

Prosjektperiode: 2005-2007

Sted: Oslo

FORNY-3-Kommersialisering av FoUresultater

Commercialisation of novel anti-psoriatic compounds

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Tildelt: kr 1,3 mill.

Prosjektperiode: 2005-2006

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Functional genomics of intracellular trafficking

A high proportion of the human genome encodes proteins that mediate or regulate intracellular membrane trafficking. Understanding the molecular basis of membrane trafficking is important for the design of novel macromolecular drugs, and our aim is to iden tify and characterize protein complexes t...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional studies of S100A4 - A Calcium-binding Protein with Metastasis-promoting Capacity

The calcium-binding protein S100A4 has convincingly been linked to the metastatic process, butt he exact mechanism of action is still unknown. The main purpose of the project is to study the molecular mechanisms behind some of the biological functions th at have been suggested tor the protein, a...

Tildelt: kr 7,3 mill.

Prosjektperiode: 2005-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Regulation of intracellular traffic by PI3P-binding proteins - a functional and ultrastructrural study

Many important cellular processes such as intracellular transport, signaling through growth hormone receptors, cell motility and apoptosis are regulated directly or indirectly by phosphatidylinositol (PI)-3-kinases. These kinases have different reaction products, one of these being PI-3-phosphat...

Tildelt: kr 7,6 mill.

Prosjektperiode: 2005-2009

Sted: Ukjent Fylke

GNBIO-Grunnleggende næringsrettet bioteknologi

Development of Reporter Mice Models for Preclinical Screening of Drug

The research group of Professor Rune Blomhoff at the University of Oslo has recently established an in vivo molecular imaging model (e.g. transgenic mice carrying NF-kB, ARE, DR5 or GCS regulated luciferase reporter) aimed at identifying factors affecting relevant gene regulation in vivo in a ph...

Tildelt: kr 3,6 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Characterization and exploration of microbial enzymes for processing of chitin, chitosan and peptidoglycan

The availability of an increasing number of microbial genomes, including the genome of the highly versatile white-rot basidiomycete Phanerochaete chrysosporium, offers unique possibilities to study and explore enzymes with potential biotechnological appli cations. In the present project, we will ...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2005-2010

Sted: Akershus

FORNY-3-Kommersialisering av FoUresultater

Development of a multiplex real-time closed tube system for single nucleotide polymorphisme (SNP) detection and quantification

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Tildelt: kr 0,10 mill.

Prosjektperiode: 2005-2005

Sted: Akershus

FORNY-3-Kommersialisering av FoUresultater

5-HT4-reseptor-ligander til medisinsk anvendelse

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Tildelt: kr 1,2 mill.

Prosjektperiode: 2005-2005

Sted: Oslo

PROSBIO-Prosess- og biomedisinsk industri

Aided Interpretation of Quantitative Genomics via Literature Networks and High Throughput Screening Integration

The scientific discipline of quantifying genomic variation using techniques such as QTL (Quantitative Trait Loci) and array-CGH (Cytogenic Genomic Hybridization) is increasingly being used with great success to unravel the genetic basis of complex traits. This growing field has the potential of ...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2005-2007

Sted: Oslo

PROSBIO-Prosess- og biomedisinsk industri

Beta-glukan som legemiddel: grunnleggende forståelse og medisinsk relevans.

Prosjektsammendrag. Biotec Pharmacon har gjennom en årrekke drevet forskning og utvikling av beta-glukaner fra gjær som immunmodulatorer. Selskapet har gjennomført en serie grunnleggende struktur/funksjonsstudier, og har gjennomført konseptbevisstudier i dyremodeller for å evaluere produktenes ev...

Tildelt: kr 3,9 mill.

Prosjektperiode: 2005-2007

Sted: Troms - Romsa - Tromssa

PROSBIO-Prosess- og biomedisinsk industri

Modified fatty acids as therapeutic agents in the treatment of the metabolic syndrome

Obesity and obesity-related disorders, often referred to as the metabolic syndrome, affect an increasing part of the population in Europe, USA and even several developing countries. This development is reflected in a high prevalence cardiovascular disease , stroke and other atheroscleroctic sympt...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2005-2007

Sted: Vestland

PROSBIO-Prosess- og biomedisinsk industri

Utvikling av prøveopparbeidingskit for påvisning av kjønnsykdommene Klamydia, Gonorre og Mycoplasma med bruk av PCR som amplifikasjonssystem

Seksuelt overførbare bakteriesykdommer lar seg behandle med antibiotika, men for å få kontroll med slike infeksjoner må det foreligge effektive og rasjonelle diagnoseverktøy. I de senere år har flere kommersielle genbaserte tester for Klamydia og Gonorre blitt introdusert, og dette vil etter hv...

Tildelt: kr 3,6 mill.

Prosjektperiode: 2005-2007

Sted: Oslo

PROSBIO-Prosess- og biomedisinsk industri

New antifungal antibiotics produced by genetically engineered bacteria

Fungal infections are on the rise, especially among HIV and cancer patients, as well as people subjected to organ transplantation. Polyene macrolide antibiotics are considered one of the best drugs for fighting invasive fungal infections. However, such ne gative properties of these antibiotics as...

Tildelt: kr 6,6 mill.

Prosjektperiode: 2005-2008

Sted: Trøndelag - Trööndelage

PROSBIO-Prosess- og biomedisinsk industri

Nye bioprosesser for norsk industri

Målsetningen med prosjektet er å utvikle teknologi og prosesser for kommersiell produksjon av mikrobielt alginat og alginatmodifiserende enzymer, farmasøytiske aktivsubstanser og vekstsubstrater for mikroorganismer. Aktiviteten skal gjennomføres ved å utn ytte den samlede kompetanse-, teknologi- ...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2005-2007

Sted: Akershus

PROSBIO-Prosess- og biomedisinsk industri

A platform for in silico analysis of short regulatory RNAs

Interagon AS will develop a platform for in silico analysis of short regulatory RNAs. The system will have a common user interface and comprise algorithms for (a) prediction of the efficacy and specificity of short interfering RNAs for RNA interference ge ne silencing experiments; and (b) predict...

Tildelt: kr 0,87 mill.

Prosjektperiode: 2005-2005

Sted: Østfold

PES-EUR-Prosjektetablererstøtte Eureka

Preklinisk og klinisk dokumentasjon av ny fotosensitiser for lys-dirigert levering av legemidler med fotokjemisk internalisering

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Tildelt: kr 87 746

Prosjektperiode: 2004-2006

Sted: Oslo

PES-EU-Prosjektetablererstøtte EU (bedrift)

Microfabricated Point-of-care diagnostic system based on mRNA detection

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Tildelt: kr 49 999

Prosjektperiode: 2004-2005

Sted: Akershus

PES-EU-Prosjektetablererstøtte EU (bedrift)

Research and development programme for the use of narrow band with cold lights in aquaculture and the effects from egg to fillet

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Tildelt: kr 99 999

Prosjektperiode: 2004-2006

Sted: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

A study of homing endonucleases: Molecular evolution and gene discovery

Homing endonuclease genes (HEGs) encode highly specific DNases responsable for the mobility and spread of group 1 introns. They are divided into four families (His-Cys box, LAGLIDADG, GIY-YIG and HNH) based on conserved protein motifs. LAGLIDADG HEGs are most numerous and widespread, while the Hi...

Tildelt: kr 0,72 mill.

Prosjektperiode: 2004-2005

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Regulation and molecular functions of replication proteins

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Tildelt: kr 14,0 mill.

Prosjektperiode: 2004-2009

Sted: Ukjent Fylke

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Identifying genes and biochemical pathways affecting disease resistance in Norwegian Cattle by functional genomics

Norwegian Red cattle show genetic gain over the last decade in resistance towards mastitis, the most costly and common production disease world wide. The project is a collaborative project with US and Norwegian partners. We will genotype Norwegian bulls a nd analyse their DNA for mutations (SNP t...

Tildelt: kr 1,4 mill.

Prosjektperiode: 2004-2007

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

Knockout zebrafish (KO-ZFISH) model

The genome projects – from microorganisms to vertebrates and mammals – create huge amounts of undeciphered genetic information. This cumulated DNA sequence bank needs intelligent, but as simple as possible, model systems to turn the currency of genomics into functional genomics. Only in one ver...

Tildelt: kr 11,0 mill.

Prosjektperiode: 2004-2009

Sted: Akershus

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