Detecting inflationary gravitational waves from the Big Bang and mapping cosmic structure formation rank among the most important goals in modern cosmology, and detailed cosmic microwave background (CMB) measurements is a uniquely powerful probe of these effects. However, the predicted signatures are tiny, and their detections require unprecedented instrumental sensitivity and systematics control. In this project I propose to develop one single massively parallel end-to-end framework for the joint analysis of past, present and future CMB experiments, and use this to combine current data from WMAP, Planck LFI+HFI and others with forthcoming measurements from Simons Observatory (SO), all processed at the level of time ordered data (TOD). I will also prepare for the analysis of future CMB experiments, including LiteBIRD, CMB-S4, and a Voyage 2050 CMB spectral distortion probe. This framework will build on an Open Source Bayesian CMB Gibbs sampler called Commander that has already played a transformational role in the field for more than two decades, and that has recently been used successfully to derive new state-of-the-art frequency maps for both Planck LFI and WMAP. However, the existing code only scales well up to O(100) computing cores, and I propose in this project a new organization that will scale it up to O(100,000) cores, as required for next-generation experiments. I will also implement a wide range of ground-breaking TOD-level corrections for key systematic effects (non-linear ADCs, cosmic ray glitches, atmospheric fluctuations, detector cross-correlations etc.) that optimally exploit synergies between experiments. Once operational, I will use this global framework to establish a new state-of-the-art model of the microwave sky; shed new light on several hotly debated LCDM tensions; and, perhaps, make the world's first detection of primordial gravitational waves. This work represents a paradigm shift in the field of computational cosmology.