Genetics across the lifespan: Unraveling age-specific determinants of severe mental illness

Genetics across the lifespan: Unraveling age-specific determinants of severe mental illness

Mental disorders affect 1 in every 8 people in the world right now. Genetic predisposition plays a crucial role in the development of severe mental disorders. Genome-wide association studies (GWAS) revolutionized the field of psychiatric genomics by identifying the individual effects of millions of common genetic variants on behavioral, cognitive, and clinical traits. However, current GWAS provide a static snapshot of genetic influences and thus misses the rich tapestry of genetic effects that unfold across an individual's lifespan. Funded by the Marie Sklodowska-Curie Actions program, the GenLife project aims to uncover novel genetic variants with age-dependent effects that have remained hidden until now. Revealing age-specific determinants of severe mental illness across the lifespan will promote the development of more effective, biology-based prediction tools tailored to individuals' disease trajectories. By providing timely support and intervention, mental health professionals will be able to identify and address emerging mental health issues before they escalate into more severe conditions. The GenLife project is based on the synergy between the applicant's highly interdisciplinary profile, cutting-edge research at the host institution, and unique Nordic resources. It will be completed at world-leading research institutions, the University of Oslo and the Norwegian Centre for Mental Disorders Research (NORMENT), under the supervision of Prof. Ole A. Andreassen. Expanding the applicant's line of research, academic maturity, and professional networks will enhance the development of his career as an independent researcher.