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HAVBRUK-Havbruk - en næring i vekst

Studies of immunophysiological reactions following vaccination in marine fisk - with emphasis on basic immune mechanisms in cod

Tildelt: kr 2,0 mill.




2001 - 2006


This project will aim at studying the imunophysiological reactions in tissues of cod and halibut vaccinated with defined antigen preparations. Special emphasis will be on the development of the in situ reactions and the involvement of specific cell types like eosinophilic granule cells or mast cells, known to contribute to the induction and maintenance of the local inflammatory reaction and thus the immune reaction. Groups of cod and halibut will be injected with agens (48/80) that specifically release th e reactive compounds from the granula of the mast cells, prior to vaccination. Further, immunomoduling agents like cortisol will also be injected prior to vaccination to study its potential influence on the inflammatory and immune reactions in situ. Chemo kines and cytokines orchestrate the immune reaction in vertebrates and very little is known about their involvement in fish. For this reason, a special attention will be given to the potential involvement of the chemokine iNOS - nitri c acid synthetase and the cytokine tumour nectrosis factor - a in cod, and their involvement in induction and maintenance of the inflammatory and immune reaction. These studies will provide novel information about the cellular and soluble components of the immune system of cod and halibut, of potential value in designing vaccines for two of the most important species in Norwegian aquaculture in the future.


HAVBRUK-Havbruk - en næring i vekst


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