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FUGE-Funksjonell genomforskn.i Norg

Mitochondrial DNA repair and implication for aging and cancer

Tildelt: kr 4,1 mill.

Prosjektleder:

Prosjektnummer:

151864

Søknadstype:

Prosjektperiode:

2003 - 2009

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Fagområder:

Mitochondrial DNA repair and implication for aging and cancer Aging and a number of age-related diseases/syndromes are associated with accumulation of oxidative DNA damages and mutations in the mitochondria. Mitchondrial DNA repair is essential to remove DNA damages and thus limit the amount of mutations in mitochondrial DNA. Use of knockout animals defect in DNA repair functions are essential to investigate mitochondrial DNA repair in vivo, and will be used in the characterization of novel mitochondrial DNA repair proteins (DNA glycosylases). In view of the central role mitochondria have in the regulation of apoptosis, the importance of mitochondrial DNA glycosylases in the regulation of apoptosis will be investigated. During the research stay in professor Bohrs laboratory, a system will be established to study apoptosis mediated by bacteria and DNA damaging agents. Finally, mice with altered mitochondrial DNA repair funtions will be used to evaluate the importance of mitocho ndrial DNA repair functions will be used to evaluate the importance of mitochondrial DNA repair for premature aging and predisposition to cancer.

Aktivitet:

FUGE-Funksjonell genomforskn.i Norg