Tilbake til søkeresultatene

BIOBIOT-Biologi, bioteknologi, Mat. Nat.

The Central Clock Dogma Contra Multiple Oscillatory Feedback Loops

Tildelt: kr 0,92 mill.

Circadian clocks play a central role in the adaptation of organisms to their environments. These clocks are found in eukaryotic single-cell and multicellular organisms and even in certain prokaryotes. A central task of these biological clocks involve the timing of physiological events on a daily and seasonal basis, as for example the onset of sporulation in fungi, sleep/wake activities in animals, hibernation, or flower induction in plants. From studies of model organisms negative feedback loops have eme rged as basic elements of circadian pacemakers. A debated question is whether circadian rhythms are ruled by a single master oscillator or whether there exist multiple autonomous clocks. At Stavanger College we are studying the circadian rhythm of nitrate reductase (NR) in the model organisms Arabidopsis and Neurospora, where clock mutants are available that have an altered or abolished circadian rhythm. These mutants are ideal study obje cts to address the above question about single or multiple circadia n clocks. In this project we investigate NR gene-transcript and activity rhythms in Arabidopsis and Neurospora clock mutants in order to test whether the NR circadian system represents a s elf-oscillating feedback loop or whether NR oscillations are being governed by a central clock.

Budsjettformål:

BIOBIOT-Biologi, bioteknologi, Mat. Nat.

Finansieringskilder

Temaer og emner

Ingen temaer knyttet til prosjektet