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BIOBIOT-Biologi, bioteknologi, Mat. Nat.

Stress and neurogenesis in rainbow trout

Tildelt: kr 1,4 mill.

It is currently agreed that new neurons are added to continually growing structures and replace old and dying brain cells in adults of all major vertebrate taxa, a process known as neurogenesis. These structural processes may be highly important for behav iour, mood, and cognition in both animals and human beings. Stress can suppress neurogenesis, an effect that has been linked to the-development of stress-related psychiatric disorders. In animal models enhanced neurogenesis is seen in the brain after trea tment with antidepressant drugs that inhibit reuptake of the neurotransmitter serotonin (5-hydroxytryptamine), and thereby increase serotonergic signaling. Compared to mammals, neurogenesis persists into adulthood to a much higher degree in the central ne rvous system of teleost fish. We have recently shown that one week of dietary treatment with the serotonin precursor, the amino acid L-tryptophan, leads to decreased aggression and enhanced stress tolerance in rainbow trout. Sim ilar to antidepressant treatment in mammalian models, shorter term tryptophan treatment does not produce behavioural effects, suggesting that the serotonin precursor may act through structural modifications in the brain. This project aims to examine how s tressful experiences impact neurogenesis in the brain of rainbow trout, and whether these changes can be counteracted by enhanced serotonergicneurotransmission through dietary tryptophan treatment.

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BIOBIOT-Biologi, bioteknologi, Mat. Nat.

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