Tilbake til søkeresultatene

HAVBRUKS-Havbruk - en næring i vekst

Function of Anti-Müllerian hormone in fish testis development and maturation to puberty

Tildelt: kr 7,4 mill.

Prosjektleder:

Prosjektnummer:

159045

Søknadstype:

Prosjektperiode:

2004 - 2010

Geografi:

This project aims to determine the function of Anti-Müllerian hormone (AMH) in fish as a factor in testis determination, development, and maturation at puberty. AMH, also named Müllerian inhibiting substance or spermatogenesis preventing substance, belong s to the transforming growth factor-ß family. In mammals, AMH is secreted from testicular Sertoli cells. In the foetus it directs Müllerian duct regression and controls spermatogenesis by suppression of Leydig cells until puberty and may be associated wit h precocious puberty . AMH is present in fish, where it has been shown to block spermatogenesis at a very early stage by preventing the differentiation of rapidly proliferating spermatogonia. We hypothesise that AMH suppresses the expression and/or activi ty of the receptor responsible for mediating the effects of 11-ketotestosterone.

Aktivitet:

HAVBRUKS-Havbruk - en næring i vekst