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HAVBRUKS-Havbruk - en næring i vekst

Improved methodologies for harvest and purification of algal toxins

Tildelt: kr 3,0 mill.





2005 - 2009


Methods for large scale harvest of toxic alga and algal toxins by pumping seawater through plankton nets and columns with adsorbent materials will be developed. Furthermore one will develop methods for enzymatic conversion of algal toxins into toxic metab olites. Clean up methods for toxins from algal cultures, sea water, shellfish and crude extracts of metabolised toxins involving fewer steps, less use of solvents and the use of more environmental friendly solvents than used in exciting methods will be de veloped. The structure of the purified compounds will be elucidated using NMR in combination with data HPLC-MS analysis. The purified toxins will be used as standards in chemical analysis of shellfish. By increasing the availability of standards, new che mical methods can be developed and validated more rapidly, thus resulting in more rapid decrease in the use of the mouse bioassay test which is widely used in testing of shellfish today. More materials will be made available for toxicity testing of algal toxins and toxin analoges. The project includes training of one female PhD candidate. Furthermore it will result in increased collaboration between those Norwegian institutions already conducting research on algal toxins and it follows up the collaborat ion established in the project NFR 139593/140. Moreover, it creates added-value to the EU funded “BIOTOX” project (contract negotiated June 2004) by scaling up the production of materials that can be used as standards in chemical analysis of shellfish. T he results from the project will place Norwegian researchers in the forefront in marine biotoxin research.


HAVBRUKS-Havbruk - en næring i vekst