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FRIMED-Klinisk medisin og folkehelse

Pregnancy, one-carbon metabolism and related single nucleotide polymorphisms

Tildelt: kr 1,8 mill.

The proposed project is possible/feasible because of two parallel ongoing scientific activities in Norway: First, the Norwegian Mother and Child Cohort Study (NMCCS) is currently collecting information on life-style, diet, anthropometric measures and bloo d samples and have recruited about 38,000 women to date. The aim is to enrol 100,000 women, their children and the fathers for short- and long-term follow-up. Second, The LOCUS for homocysteine and related vitamins has laboratory facilities of high intern ational standard to perform high throughput analyses of a panel of B-vitamins, B-vitamin markers, related one-carbon metabolites and 14 single nucleotide polymorphisms (SNPs) related to these pathways. While the primary example of the importance of B-vit amins in pregnancy is the prevention of neural tube defects by preconceptional folate supplementation or food fortification, the current scientific evidence is suggestive of a wider role of folate, folate markers, related vitamins, metabolites and SNPs as risk factors or causes of pregnancy complications, adverse pregnancy outcomes, and malformations other than neural tube defects. No large-scale prospective studies have been conducted. The project will describe B-vitamin status in 2,500 women at week 17- 19 and relate status to low birth weight as well as placental abruption and preeclampsia. The study will provide unique information as many of these factors have never been measured in a large and rigorously designed prospective study.

Budsjettformål:

FRIMED-Klinisk medisin og folkehelse

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