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FRIMED-Klinisk medisin og folkehelse

NOVEL BIOTHERAPEUTIC STRATEGIES FOR IMPROVING IMPLANT PERFORMANCE IN BONE

Tildelt: kr 4,5 mill.

The purpose of this project is to characterize mechanisms for bone regeneration and healing and to use this knowledge to develop new strategies for improving the performance of loaded metal implants used to restore function in compromised skeletal structu res. From the clinical perspective skeletal implants, including dental and orthopaedic devices should be able to withstand loading as soon as possible after placing. A shortened postoperative period is important to avoid serious complications and to resto re skeletal function before irreversible physiological, pathological and morphological changes are manifest. For the community a shortened "time to load" also is synonymous with reduced recovery costs and improved health care services. Moreover, if metal implant surfaces can be modified to allow an optimal and stable integration into boney tissues, the need for revisions of failing implants will be reduced with accordingly positive outcomes for patients and community alike. Thus, to achieve an optimal bio logical reaction in the bone following replacing of an implant, and to develop new biomimetic strategies for improved implant performance in bone, 3 major factors must be optimized and carefully controlled. These are: 1) The surface structure and surface chemistry of the implanted device, 2) The nature and quality of the tissue-implant interface and the peri-implant environment, 3) The physiology and biology of the healing process in the compromised bone. Each of these topics will be studied in 3 collabo rating sub-projects addressing several research areas including material science, biofilm aggregation, extra-cellular matrix biology and bone biology. By taking full advantage of the multidiciplinary research environment, the highly experienced researcher s behind this application aims at establishing a problem oriented, innovative project team with high productivity and a high change for success in this brave project at the forefront of biomaterial research.

Budsjettformål:

FRIMED-Klinisk medisin og folkehelse

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