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BIONÆR-Bionæringsprogram

Reducing campylobacter jejuni in the food chain by modifying the upper digestive tract of slaughter chicken

Tildelt: kr 5,1 mill.

The zoonotic pathogen C. jejuni is the leading cause of food-borne bacterial diarrhoeal disease throughout the world. C. jejuni readily colonize poultry and represents a major problem for the poultry industry and is a potential public health hazard throug h its high ability to survive in unprocessed poultry products. Despite major efforts, there are currently no really successful strategies for reduction or elimination of this bacterium from the food chain. The main approaches evaluated until now include h ygienic barriers, diagnostics at the flock level, competitive exclusion and decontamination. To our knowledge approaches targeting the upper digestive tract have not yet been evaluated with respect to Campylobacter elimination. The chicken has several na tural barriers in the upper digestive tract in order to kill pathogens, including lactic acid bacteria in the crop, and hydrochloric acid in the gizzard. The properties of these barriers will be modified and optimised for killing of C. jejuni within the f rame of the proposed project. Previous work has shown that the development and activity of the gizzard (including the secretion of hydrochloric acid) can be controlled through feed structure. Feed structure has also been shown to influence the incidence of Salmonella in the gizzard of broilers. Nothing has however been done to modify the gizzard with respect to reducing C. jejuni colonization. In addition to feed structure and gizzard development we also want to evaluate the reduction effect of non-ant ibiotic antimicrobal compounds. Our hypothesis is that reduction of C. jejuni in the upper digestive tract will reduce the ability of this bacterium to colonize the lower digestive tract, thereby reducing the load in poultry products.

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BIONÆR-Bionæringsprogram