Systems Biology aims at understanding and predicting the properties of a biological system under targeted
perturbations (e.g. genetic changes or changes in the external environment) with the use of integrated data
analyses and mathematical modelling.
It r equires a multidisciplinary approach including cell cultivation, molecular biology, bioinformatics, statistical
analyses and mathematical modelling. Systems Biology is expected to have strong influence and impact on future
biotechnological research, rangi ng from industrial biotechnology to molecular medicine. Our goal is to get insight into the molecular mechanisms behind antibiotic production in Streptomyces coelicolor by a Systems Biology approach. We aim at understanding pathway networking in this comp lex oligotroph organism where there are clear links between primary and secondary metabolism. Key factors in the regulation of secondary metabolites will be studied at omics level (genomics,transcriptomics, proteomics, metabolomics and fluxomics) combined with computational and mathematical modelling. To reach our goal we will combine our efforts with 14 international partners in the SysMO-project with competence in molecular biology, experimental and theoretical analyses.
See further details in the SysM O application in appendix