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FUGE-Funksjonell genomforskn.i Norg

Global metabolic switching in Streptomyces coelicolor

Tildelt: kr 3,2 mill.

Systems Biology aims at understanding and predicting the properties of a biological system under targeted perturbations (e.g. genetic changes or changes in the external environment) with the use of integrated data analyses and mathematical modelling. It r equires a multidisciplinary approach including cell cultivation, molecular biology, bioinformatics, statistical analyses and mathematical modelling. Systems Biology is expected to have strong influence and impact on future biotechnological research, rangi ng from industrial biotechnology to molecular medicine. Our goal is to get insight into the molecular mechanisms behind antibiotic production in Streptomyces coelicolor by a Systems Biology approach. We aim at understanding pathway networking in this comp lex oligotroph organism where there are clear links between primary and secondary metabolism. Key factors in the regulation of secondary metabolites will be studied at omics level (genomics,transcriptomics, proteomics, metabolomics and fluxomics) combined with computational and mathematical modelling. To reach our goal we will combine our efforts with 14 international partners in the SysMO-project with competence in molecular biology, experimental and theoretical analyses. See further details in the SysM O application in appendix

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FUGE-Funksjonell genomforskn.i Norg