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FUGE-Funksjonell genomforskn.i Norg

Mechanisms mediating transfer and persistence of antibiotic resistance, and dissemination of virulence genes in streptococci and enterococci

Tildelt: kr 5,3 mill.

The present project will study mechanisms for genome variation and maintenance in two closely related groups of bacteria Streptocococcus pneumonia and Enterococcus (E. faecalis and E. faecium). While S. pneumonia is considered as a sole pathogen, though 4 0% of humans carry this species, the two Enterococcus species are considered both as pathogens, commensal and probiotic bacteria. The efficient competence dependent DNA uptake mechanism in S. pneumonia is manifested through the increased frequency of peni cillin and macrolide resistance throughout the world. The project will follow up the study of this mechanism of horizontal DNA transfer. Enterococci are considered a hub for antibiotic resistance and multidrug resistant hospital adapted lineages of entero cocci pose a serious risk for patients worldwide. Plasmids and transposons carried are often involved in antibiotic resistance transfer within and from enterococci and the project has a focus on the mechanism of plasmid stability through a post segregatio n killing system (toxin-antitoxin). An important aspect of bacterial genome stability/plasticity is not only to understand the mechanisms behind this great variation in gene content and genome localization but also the importance of putative ABR and virul ence genes in order to transfer it to a pathogenic bacterium. Consequently we will take a genomic approach to elucidate such phenotypic features of these groups of bacteria.

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FUGE-Funksjonell genomforskn.i Norg