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Advanced equipment for global analysis of genome structure and function: Hybridization and scanning system for next generation high-density

Tildelt: kr 1,8 mill.

The FUGE Microarray Platform is based on a formal institutional collaboration between three equal partners: the National Hospital-the Norwegian Radium Hospital/the University of Oslo, the Norwegian University of Science and Technology and the University o f Bergen. The activities include production of NMC standard and custom-designed arrays, complete expression and genomic profiling services on several different technology platforms, and user support on experimental design and data analysis. NMC also offer s courses and training. The microarray bioinformatics effort is done in collaboration with the FUGE-funded Bioinformatics platform. NMC has fostered a large increase in microarray-based functional genomics research in Norway. At present, NMC has trained a nd served about 250 reseachers from all regions in Norway, and several international customers. A web-based NMC user survey in Sept.-Oct. -05 demonstrated that a large majority of the users were satisfied with our products and service, and that the availa bility of competence and support was the most important aspect. The MR-technology is under continuous development, and NMC will do its outmost to continue to offer state-of-the-art methods for the best of the Norwegian research community. A steady stream of new high throughput array types will be implemented, incl. splicing arrays, genome-tiling, ChIP-chip, methylation assays, miRNA and various other formats. In line with these methodological developments, NMC intends to establ. two additional commercial technologies for extended service within the consortium during the initial phase of FUGEII. The NimbleGen system covers different applications and species, with flexible and affordable custom options, with launching of a novel high density chip. The UiB n ode will take responsibility within NMC for setting up the new system. The present application relates to funding of the hybridization and scanning equipment that is necessary to run such high density microarrays.

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