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TU-Tungt utstyr

High resolution multi-dimensional imaging of cell signalling networks.

Tildelt: kr 2,7 mill.

The Biotechnology Centre of Oslo (BiO) at the University of Oslo is a centre for functional genomics, currently consisting of six internationally competitive research groups headed by Drs. Taskén, Nilsen, Thiede, Chaudhry, Donaldson and Leitges. BiO also has an open position for a seventh new group leader and is currently recruiting to this position. As the reorganization of BiO progresses BiO will expand to approximately 100 staff over the next few years. The research focus at BiO is aimed at understandi ng and solving cellular communication and intracellular signalling networks, using key technologies such as proteomics, bioinformatics, molecular and cell biology, and molecular imaging. A current focus in cutting-edge signalling research is the precise s patio-temporal organization of signalling events. One of our main challenges is to monitor dynamic molecular events in their functional environment, i.e. in living cells in situ. An advanced live-cell imaging system, capable of following the dynamic behav iour of cellular signalling pathways at high resolution both spatially and temporally will be an essential complement to our intensive work on protein-protein interactions using static methods. The multi-dimentional imaging unit will also be crucial in at tracting a top international candidate for the new position at BiO from 2007. In our negotiation with the two top candidates, it is clear that a key question in this strategic recruitment will be the access to multi-dimentional imaging. The application wa s prioritised by the UiO Equipment Committee in the ordinary 2007-round, but not funded, and is therefore forwarded now as this is the most strategically important priority for BiO.

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TU-Tungt utstyr

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