Acquisition and Analysis of Perfusion Imaging Data using Ultrasound and Magnetic Resonance Imaging

The aim of the proposed project is to increase the diagnostic potential of magnetic resonance imaging (MRI) and ultrasonography when applying a contrast agent. The core application of the project is perfusion imaging, i.e. imaging of tissue perfusion para meters (e.g. blood flow, blood volume and transit time), based on analysis of contrast-agent concentration time-curve after intravenous bolus administration. The voxel-specific contrast-agent concentration time-curves acquired using MRI or ultrasound will be analyzed. Based on pharmacokinetic models, new robust deconvolution methods will be designed for estimation of the perfusion parameters. This will lead to more reliable quantitative perfusion imaging in both modalities. The aim of the research stay in Norway is to continue in cooperation between institutions incorporated in the joint project on perfusion analysis using MRI and ultrasonography. In particular the aim is to complete the software for perfusion analysis. This software is being developed fo r clinical research at the university hospital in Bergen. For successful work the interaction between technicians and medical doctors is unavoidable.