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FRIMEDBIO-Fri prosj.st. med.,helse,biol

4th EU-US meeting on Endogenous genome damage

Tildelt: kr 0,15 mill.

The main scientific focus of this meeting will be on DNA repair mechanisms and mutagenesis. Most mutagenic and carcinogenic agents induce covalent changes in the structure of the DNA and living organisms have evolved a large number of gene functions speci fically designed to repair or tolerate such alterations without loss of viability or development of disease. DNA repair mechanisms are probably the most important cellular protection against the development of cancer and are also essential for living cell s to survive in an environment that would otherwise cause unacceptable mutation frequencies. The importance of DNA repair for normal life existence has been verified by discoveries of coupling between transcription and repair, by association between DNA r epair and cell- cycle checkpoints, and by identification of nucleotide excision and mismatch repair genes being essential for prevention of cancer and neurological disease in man. We have included a preliminary program which includes 30 invited speakers ; 24 international and 6 from Norway (see list of speakers below). The speaker list is a mixture of young scientists and internationally recognized experts. We are also strongly encouraging graduate students and postdocs to participate at the meeting with posters and will include short presentations from selected abstracts. Topics include mutagenic DNA processing, translesion synthesis, DNA damage and repair as therapeutic target, DNA repair and aging, DNA repair and chromatin remodeling, and cancer and t elomere repair. Program and registration will be announced on a website for this meeting.

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FRIMEDBIO-Fri prosj.st. med.,helse,biol

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