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BIOTEK2021-Bioteknologi for verdiskaping

Novel industrial bioprocesses for production of key valuable steroid precursors from phytosterol

Tildelt: kr 3,6 mill.

Project MySterI (Mycobacterial Steroids for Industry) aims to produce high value steroid precursors using a novel bioconversion strategy resulting in lower production costs and less cost to the environment. The aim is to convert phytosterols in cheap wast e plant material to desired steroid precursors with engineered strains of fast-growing, saprophytic mycobacteria in single fermentation steps. The bioconversion of phytosterols has not been widely adopted in the biotechnology industry because of problems with microbial strains, process efficiency and therefore poor yield. At the heart of project MySterI is the bioconversion of phytosterols to 3-B-hydroxyandrost-5-ene-17-one (DHEA) or to androst-4-ene-3,17-dione (AD) (intermediary precursor) and then to 11 -a-hydroxyandrost-4-ene-3,17-dione (11-a-OH-AD) and testosterone.

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BIOTEK2021-Bioteknologi for verdiskaping