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IS-TOPP-Toppfinans. av M.Curie-stipend

Rheumatiod Arthritis and Periodontal Inflammatory Disease (RAPID)

Tildelt: kr 0,51 mill.

The most prevalent chronic inflammatory diseases of humans are complex disorders influenced by genes, environment and their interactions. Periodontitis (PD) and rheumatoid arthritis (RA) are two such chronic inflammatory diseases associated with significant morbidity and mortality, and have recently shown to have a bi-directional association. RA and PD share common risk factors and pathogenic mechanisms. Moreover, the prevalence of both increases substantially with age, and given both the Europe-wide ageing population and the impact of both diseases upon the economy, health and quality of life, it is clear that novel and more cost effective approaches to management are urgently required. Radical improvements are necessary in: i) understanding the pathological processes that trigger disease initiation and progression, ii) the generation of novel diagnostic and treatment strategies and iii) developing new researchers able to advance the field. A key research goal of this project is to improve understanding of the pathogenesis of RA and PD and their inter-relationships, through the study of common risk factors linked to the activation of host and bacterial derived protein citrullination, which subsequently generates pro- inflammatory auto-antigens in the joints and periodontal tissues. RAPID aims to provide a significant contribution to this by establishing a first class, dynamic training programme for early career researchers who will be able to advance both fields by working across sectors and disciplines. RAPID?s objectives include attracting the best European early career researchers into this area by providing carefully designed and integrated research projects and structured training delivered by the highest-quality European scientists.

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IS-TOPP-Toppfinans. av M.Curie-stipend

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