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INTPART-International Partnerships for Excellent Education and Research

Trans-Atlantic Consortium in Computational Neuroscience

Alternativ tittel: US-Norwegian Partnership in Quantitative Neurobiology

Tildelt: kr 4,0 mill.

NeuroComp ønsker å utvikle et samarbeid mellom ledende forskere i Norge og California innen nevrovitenskap og beregningsorientert biologi. Hjernen sin kompleksitet krever at tilsvarende komplekse matematiske og beregningsorienterte metoder blir utviklet, så vi kan forstå hvordan hjernen oppfatter, lærer og tenker på verden rundt oss. Disse metodene kan bli brukt for å forbedre hvordan vi utfører og analyserer eksperimenter, og muliggjør bruk av datamaskiner for å simulere hvordan populasjoner med celler (nevroner) interagerer for blant annet gi oss syn, og lagre minner. I mange sykdommer, og selv i normale prosesser som aldring, endrer disse egenskapene seg. Derfor er matematiske og beregningsorienterte metoder nøkkelen for å forstå hvordan arv, miljø, og medisiner påvirker hjernens funksjon og hvordan de kan brukes til å forbedre resultatene i psykisk helse. Med NeuroComp kombinerer vi kompetanse innen medisin, biologi, datavitenskap og matematikk for å generere nye matematiske og beregningsorienterte verktøy for disse formålene. NeuroComp muliggjør at både unge og seniorforskere ved Universitetet i Oslo (UiO), Universitetet i California, San Diego (UCSD) og Simula Research Laboratory (Simula) kan samarbeide hyppig og effektivt med forskningsproblemene i neurobiologi og psykologi de jobber sammen for å løse. I tillegg har NeuroComp vært instrumentell for finansieringen av nevrobiologer i en sommerskole i beregningsorientert fysiologi gjennomført av Simula og UCSD i 2016, 2017 og 2018. Sommerskolen dekker de sentrale delene av materialet i NeuroComp, og eksponerer norske studenter til verdensledende internasjonale forskere i sterke tverrfaglige miljø. Verktøy utviklet av gruppene deles, fremvises og demonstreres gjennom skolen.

The primary objective of this project was to build an internationally recognized collaboration in neuroscience and multiscale electrophysiology between Simula, UiO, and UCSD. These desired outcomes were achieved within two areas: education and research. The funding has been used to: (1) support travel of Norwegian researchers to UCSD, (2) fund expenses associated with our summer school in computational electrophysiology, and (3) support a 2-day workshop for NeuroComp investigators and trainees at UCSD. In the reporting period this has amounted to 10 individual exchange visits to the USA and 1 to Norway. The work conducted in these visits has contributed to at least 10 published articles or book chapters, supported dissemination of these findings at major international conferences in the USA, and yielded new computational tools associated neurophysiology. We have also strengthened and developed collaborations between world-class investigators which will continue in the coming years.

NeuroComp seeks to advance research and education in computational neuroscience through developing collaborations between the University of Oslo (UiO), Simula, and the University of California San Diego. Scientifically, NeuroComp specifically focuses on developing methods and software for (1) analyzing large scale or complex experimental data; (2) development, distribution and standardisation of multiphysics models in neurobiology. To achieve these goals we have assembled a world-class group of investigators. At UiO, Drs. Marianne Fyhn, Gaute Einevoll, and Anders Malthe-Sørenssen represent the Center for Neural Plasticity (CINPLA). CINPLA is an initiative for multidisciplinary PhD training and research in neuroscience, and is led by Drs. Fyhn and Einevoll, both of whom are internationally renowned investigators. At Simula, the Center for Computational Biomedicine (CBC, a center of excellence) including Drs. Andy Edwards, Kyrre Lekve, and Aslak Tveito will support the neurophysiological expertise of CINPLA and provide a home for NeuroComp. They will also deliver extensive experience in computational and experimental electrophysiology, and implementation, distribution and standardisation of software in computational multiphysics. At UCSD, Drs. Anna Devor, Anders Dale, Jill and Stefan Leutgeb, and Andrew McCulloch, cover experimental expertise from the cellular to whole-brain level, and computational modeling from single proteins to whole-organ electrophysiology. Together this constitutes a truly world leading group in neuroscience and electrophysiology. NeuroComp will support an annual Summer School (primarily educational), as well as broad mobility for investigators and students. All of these activities is highly consistent with the goals of INTPART, and importantly, they will also directly add value to the existing doctoral training programs at UiO (CINPLA) and SIMULA (SUURPh, see full project description)

Budsjettformål:

INTPART-International Partnerships for Excellent Education and Research