Transglutaminase in disease: a novel therapeutic target?

TRANSPATH is a multisectorial Network designed to facilitate the Exchange of knowledge and techology between 7 leading European Research teams and 3 SME partners and 2 associate SME partners involved in basic and appleid Research into transglutamincase (TG) related human diseases. ITs ambitions are to accelreate the Development of New strategies for the treatment and diagnosis of human diseases related to transglutaminases, including metastatic cancer, neurodegeneration and celiac disease. The subject is highly relevant as deregulation of tissue transglutaminase. Activity is observed in a number of human diseases while the exact mechanisms are still largely unknown. The projectarget this unmet clinical need.