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Impact of neuronal DNA methylomes on neural coding of spatial learning and memory

Tildelt: kr 0,50 mill.

Memory formation and maintenance are tightly controlled complex processes, and understanding the underlying molecular, cellular and network mechanisms are major goals in the field of neuroscience. Recently, emerging evidence links memory formation and storage to dynamic changes in DNA methylation. The distinct and unique methylation patterns of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in mature neurons support the notion that dynamic neuronal DNA methylomes are prerequisite for cognitive processes. In this project, I will use transgenic mouse models that have depletion of essential enzymes, such as TET hydroxylases, TDG and Neil DNA glycosylases, involving in regulation of 5mC/5hmC distributions. I aim to unravel the epigenetic basis of neuronal ensembles and neural circuits in the entorhinal-hippocampal spatial representation system and to identify distinct neuronal DNA methylomes as key regulators for neural coding of spatial learning and memory. This project will open a novel research field that links molecular mechanisms such as epigenetic regulation to the functionally specialized neuronal ensembles and neural circuits, which are key for understanding cognitive brain functions and will be beneficial for potential molecular treatments in brain diseases.

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POS-ERC-Støtte til ERC søkere som oppnår god evaluering

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